In this issue of JAMA Psychiatry, Periyasamy et al1 report that , a single-nucleotide polymorphism, is associated with schizophrenia. In other words, when the investigators compared the frequency of alleles (variants) from a panel of single-nucleotide polymorphisms, the frequency of allele A of this biallelic genetic polymorphism was significantly higher among patients with schizophrenia than control participants, based on a genome-wide association study (GWAS). The authors1 thus contend that the A allele of is a risk factor for schizophrenia. The estimated risk is modest, with an odds ratio of 1.27, but it is significant after corrections for genome-wide multiple comparisons (P鈥�=鈥�4.35鈥壝椻赌�10鈭�8).