Congenital cytomegalovirus (cCMV) can be considered an elephant in our living room. Since Weller1 published his landmark article in 1971 reporting the ubiquity of the problem of cCMV infection in the United States and stressing its major public health importance, cCMV has been recognized as a common congenital infection that can cause liver disease, thrombocytopenia, hearing and vision loss, microcephaly, and neurodevelopmental disorders. Despite how long we have known how common and destructive CMV can be, little has been done to stop this virus from affecting our newborns.