In the current issue of JAMA, the US Preventive Services Task Force (USPSTF) has published the results of its most recent evidence reviews and recommendations on screening for lipid disorders in children and adolescents.1-3 The recommendation statement is an I statement, meaning that the USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for lipid disorders in children and adolescents 20 years or younger. This is an update of the last statement, which had a similar recommendation and grade.4