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HIMALAYA Overall Survival Prominence and Other Routes to the Peak | Oncology | JAMA Oncology | vlog

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Comment & Response
January 11, 2024

HIMALAYA Overall Survival Prominence and Other Routes to the Peak

Author Affiliations
  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
  • 2Weill Medical College, Cornell University, New York, New York
  • 3Trinity College Dublin, Dublin, Ireland
  • 4Liver Unit and HPB Oncology Area, Clínica Universidad de Navarra and CIBEREHD, Pamplona, Spain
JAMA Oncol. 2024;10(3):409. doi:10.1001/jamaoncol.2023.6268

To the Editor We read with interest the Review by Cappuyns and colleagues1 comparing the clinical benefit and safety profile of the recommended first-line and second-line drug regimens for advanced hepatocellular carcinoma (HCC). However, we have identified errors in the article, including an incorrect reference to guidelines limiting the STRIDE (single tremelimumab regular interval durvalumab) regimen to patients ineligible to receive bevacizumab rather than as a preferred first-line regimen. The American Association for the Study of Liver Diseases guidance document cited in the article (and published May 2023) indicates: “Systemic therapies with atezolizumab plus bevacizumab or durvalumab plus tremelimumab are considered as preferred first-line therapy options.” In addition, the authors1 self-tabulated a European Society for Medical Oncology–Magnitude of Clinical Benefit Scale (ESMO-MCBS) score of 3 for STRIDE, which in actuality was assessed as a 5 (November 2022) and reflected as such in the ESMO-MCBS scorecard.2 It follows that these errors should be addressed to more accurately inform the medical community of the current state of systemic therapies available to help patients with HCC.

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