Amrou Sarraj, MD; Nitin Goyal, MD; Michael Chen, MD; et al.
free access
JAMA Neurol. 2021;78(8):916-926. doi:10.1001/jamaneurol.2021.1707
This pooled cohort study evaluates the functional and safety outcomes of the direct to angiography vs repeated imaging approaches in the different treatment windows and on-call vs regular hours in patients with large vessel occlusion undergoing transfer for endovascular thrombectomy.
Kimford J. Meador, MD; Morris J. Cohen, EdD; David W. Loring, PhD; et al.
free access
JAMA Neurol. 2021;78(8):927-936. doi:10.1001/jamaneurol.2021.1583
This multicenter cohort study compares children at 2 years of age with and without fetal exposure to antiseizure medications and assesses the association of maximum exposure to these medications in the third trimester of pregnancy with neurodevelopment.
Alexandre Bejanin, PhD; Maria Florencia Iulita, PhD; Eduard Vilaplana, PhD; et al.
open access
JAMA Neurol. 2021;78(8):937-947. doi:10.1001/jamaneurol.2021.1893
This cohort study examines Alzheimer disease symptoms and age at onset; changes in amyloid, tau, and neurodegeneration biomarkers; and topography of brain changes in adults with Down syndrome.
Tom Aschman, MD; Julia Schneider, MSc; Selina Greuel, MD; et al.
free access
JAMA Neurol. 2021;78(8):948-960. doi:10.1001/jamaneurol.2021.2004
This case-control autopsy series aims to identify differences in skeletal muscle and myocardial inflammation in patients who died with COVID-19 vs other diseases.
Rik Ossenkoppele, PhD; Ruben Smith, MD, PhD; Niklas Mattsson-Carlgren, MD, PhD; et al.
open access
has audio
JAMA Neurol. 2021;78(8):961-971. doi:10.1001/jamaneurol.2021.1858
This prognostic study examines the prognostic accuracy of baseline [18F]flortaucipir and [18F]RO948 (tau) positron emission tomography (PET) in individuals across the Alzheimer disease clinical spectrum and performs a head-to-head comparison with established magnetic resonance imaging and amyloid PET markers.
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Podcast:
Tau PET as a Prognostic Marker
Gordon Duffley, PhD; Barbara J. Lutz, PhD; Aniko Szabo, PhD; et al.
free access
JAMA Neurol. 2021;78(8):972-981. doi:10.1001/jamaneurol.2021.1910
This randomized clinical trial of individuals with Parkinson disease compares the efficacy of deep brain stimulation managed postoperatively by a home health nurse with the existing standard of in-clinic postoperative management.
Michael A. McCrea, PhD; Joseph T. Giacino, PhD; Jason Barber, MS; et al.
free access
JAMA Neurol. 2021;78(8):982-992. doi:10.1001/jamaneurol.2021.2043
This cohort study assesses outcomes in major areas of life functions at 2 weeks and 3, 6, and 12 months after moderate to severe traumatic brain injury.
Adam J. Kundishora, MD; Samuel T. Peters, BS; Amélie Pinard, PhD; et al.
free access
JAMA Neurol. 2021;78(8):993-1003. doi:10.1001/jamaneurol.2021.1681
This genetic association study analyzes genetic characteristics of patients with moyamoya disease.