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October 2024 - July 1959

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Issue

May 2021, Vol 78, No. 5, Pages 514-620

Viewpoint

Administering Thrombolysis for Acute Ischemic Stroke in Patients Taking Direct Oral Anticoagulants: To Treat or How to Treat

Abstract Full Text
JAMA Neurol. 2021;78(5):515-516. doi:10.1001/jamaneurol.2021.0287

This Viewpoint discusses the when and how to best administer thrombolysis for patients with acute ischemic stroke taking direct oral anticoagulants.

Complexities of Reperfusion Therapy in Patients With Ischemic Stroke Pretreated With Direct Oral Anticoagulants: To Treat or Not, and How?

Abstract Full Text
JAMA Neurol. 2021;78(5):517-518. doi:10.1001/jamaneurol.2021.0290

This Viewpoint describes current issues with the use of thrombolysis in patients who have acute ischemic stroke but have recently been or are concurrently being treated with direct oral anticoagulation.

On the Brain

No Time for This

Abstract Full Text
JAMA Neurol. 2021;78(5):519-520. doi:10.1001/jamaneurol.2021.0481

This essay discusses the author’s experience with stuttering as a medical student and how injustices surrounding speech fluency affect minoritized individuals.

Editorial

JAMA Neurology—The Year in Review, 2020

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):521-522. doi:10.1001/jamaneurol.2021.0123

Holding Out Hope After Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2021;78(5):522-524. doi:10.1001/jamaneurol.2020.5328

A Link Between Cardiovascular Risk Management and Alzheimer Disease Is Still Elusive

Abstract Full Text
JAMA Neurol. 2021;78(5):524-526. doi:10.1001/jamaneurol.2021.0083
Original Investigation

Reperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity

Abstract Full Text
free access has audio
JAMA Neurol. 2021;78(5):527-535. doi:10.1001/jamaneurol.2021.0023

This study describes differences in care patterns and outcomes among patients with acute ischemic stroke who present to hospitals with and without telestroke capacity.

Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):536-547. doi:10.1001/jamaneurol.2021.0504

This study evaluates the range and severity of neurologic involvement among children and adolescents associated with COVID-19.

Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):548-557. doi:10.1001/jamaneurol.2021.0084

This cohort study analyzes the neuroanatomic, functional, and other outcomes during the emergent, critical care, and rehabilitation phases after new-onset traumatic brain injury with disrupted consciousness.

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2021;78(5):558-567. doi:10.1001/jamaneurol.2021.0405

This superiority study compares the efficacy of ponesimod, a selective sphingosine-1-phosphate receptor 1 modulator with teriflunomide, a pyrimidine synthesis inhibitor, approved for the treatment of patients with relapsing multiple sclerosis.

Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):568-577. doi:10.1001/jamaneurol.2021.0178

This secondary analysis of a randomized clinical trial evaluates the association of intensive blood pressure control on Alzheimer disease–related brain biomarkers.

Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):578-587. doi:10.1001/jamaneurol.2021.0306

This cohort study examines the prevalence of incidental findings identified on brain magnetic resonance imaging in children from the general population.

Association Between Treatment Progression, Disease Refractoriness, and Burden of Illness Among Hospitalized Patients With Status Epilepticus

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):588-595. doi:10.1001/jamaneurol.2021.0520

This cross-sectional study compares the outcomes and costs of treatments among patients with low, moderate, and highly refractive status epilepticus.

Review

Association of Pharmacological Interventions With Symptom Burden Reduction in Patients With Mild Traumatic Brain Injury: A Systematic Review

Abstract Full Text
JAMA Neurol. 2021;78(5):596-608. doi:10.1001/jamaneurol.2020.5079

This systematic review examines studies of pharmacological interventions to assess their associations with symptom burden reduction among patients with mild traumatic brain injury and to identify directions for future research that may aid in clinical decision-making.

Images in Neurology

Absent Blood Oxygen Level–Dependent Functional Magnetic Resonance Imaging Activation of the Orbitofrontal Cortex in a Patient With Persistent Cacosmia and Cacogeusia After COVID-19 Infection

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):609-610. doi:10.1001/jamaneurol.2021.0009

This case report describes absent blood oxygen level–dependent (BOLD) functional magnetic resonance imaging (fMRI) activation of the orbitofrontal cortex in a 25-year-old woman with persistent cacosmia and cacogeusia after coronavirus disease 2019 (COVID-19) infection.

The Trade-off Between the Bony Carotid Canal and Internal Carotid Artery

Abstract Full Text
JAMA Neurol. 2021;78(5):611-612. doi:10.1001/jamaneurol.2021.0344

This case report describes a woman initially diagnosed with Takayasu arteritis who was later found to have gradual narrowing of the left carotid canal, a so-called black swan.

JAMA Neurology Clinical Challenge

Headache, Cognitive Decline, and a Curious Rim-Enhancing Lesion

Abstract Full Text
JAMA Neurol. 2021;78(5):613-614. doi:10.1001/jamaneurol.2021.0161

A 75-year-old man presents with severe, persistent headache and right eye pain, with a large T2-hyperintense lesion in the right temporoparietal region and an increased diffusion-weighted imaging signal on magnetic resonance imaging. What is your diagnosis?

Research Letter

Local Cerebral Recombinant Tissue Plasminogen Activator Concentrations During Acute Stroke

Abstract Full Text
open access
JAMA Neurol. 2021;78(5):615-617. doi:10.1001/jamaneurol.2021.0065

This study evaluates concentrations of local cerebral recombinant tissue plasminogen activator during mechanical thrombectomy treatment in acute stroke.

Residual Fatigue and Cognitive Deficits in Patients After Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis

Abstract Full Text
open access
JAMA Neurol. 2021;78(5):617-619. doi:10.1001/jamaneurol.2021.0477

This study evaluates residual fatigue and cognitive defects in patients after leucine-rich glioma-inactivated 1 antibody encephalitis.

Comment & Response

Insights on Intensive vs Nonintensive Prerandomization Systolic Blood Pressure Reduction

Abstract Full Text
JAMA Neurol. 2021;78(5):619-620. doi:10.1001/jamaneurol.2021.0258

Insights on Intensive Vs Nonintensive Prerandomization Systolic Blood Pressure Reduction—Reply

Abstract Full Text
JAMA Neurol. 2021;78(5):620. doi:10.1001/jamaneurol.2021.0261
Correction

Error in Author Name

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):620. doi:10.1001/jamaneurol.2021.0456
Peer Reviewers List

JAMA Neurology Peer Reviewers in 2020

Abstract Full Text
free access online only
JAMA Neurol. 2021;78(5):e210212. doi:10.1001/jamaneurol.2021.0212
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2021;78(5):514. doi:10.1001/jamaneurol.2020.3661
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