Shorena Janelidze, PhD; David Berron, PhD; Ruben Smith, MD, PhD; et al.
open access
JAMA Neurol. 2021;78(2):149-156. doi:10.1001/jamaneurol.2020.4201
This cohort study compares plasma levels of phosphorylated tau at threonine 217 with established cerebrospinal fluid and positron emission tomography (PET) tau biomarkers in early Alzheimer disease.
T. Truc My Nguyen, MD; Ido R. van den Wijngaard, PhD; Jan Bosch, MSc; et al.
free access
has audio
JAMA Neurol. 2021;78(2):157-164. doi:10.1001/jamaneurol.2020.4418
This cohort study performs external validations, head-to-head comparisons, and feasibility ratings of 7 scales used by emergency medical services in the field to predict symptomatic large anterior vessel occlusion among patients suspected of acute stroke.
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Podcast:
Prehospital Prediction of Large Anterior Vessel Occlusion
GBD 2017 US Neurological Disorders Collaborators
open access
JAMA Neurol. 2021;78(2):165-176. doi:10.1001/jamaneurol.2020.4152
This analysis of the Global Burden of Disease 2017 study presents burden estimates of major neurological disorders in the US states by age and sex from 1990 to 2017.
Pierre Amarenco, MD; Hans Denison, MD, PhD; Scott R. Evans, PhD; et al.
open access
JAMA Neurol. 2021;78(2):177-185. doi:10.1001/jamaneurol.2020.4396
This randomized clinical trial evaluates the superiority of ticagrelor added to aspirin in preventing disabling stroke and identifies factors associated with recurrent disabling stroke.
Brian J. Wainger, MD, PhD; Eric A. Macklin, PhD; Steve Vucic, PhD; et al.
free access
JAMA Neurol. 2021;78(2):186-196. doi:10.1001/jamaneurol.2020.4300
This randomized clinical trial examines the use of clinical neurophysiological metrics of excitability as pharmacodynamic biomarkers in individuals with amyotrophic lateral sclerosis.
Leonardo Iaccarino, PhD; Renaud La Joie, PhD; Orit H. Lesman-Segev, MD; et al.
free access
JAMA Neurol. 2021;78(2):197-207. doi:10.1001/jamaneurol.2020.3962
This cross-sectional study examines how environmental risk factors, such as air quality, affect Alzheimer disease or dementia pathology.
Hendrik Reinink, MD; Eric Jüttler, MD; Werner Hacke, MD; et al.
free access
JAMA Neurol. 2021;78(2):208-216. doi:10.1001/jamaneurol.2020.3745
This systematic review and individual patient meta-analysis of randomized clinical trials compares surgical decompression with medical care for space-occupying hemispheric infarction and whether patient characteristics are associated with treatment outcomes.
David S. Knopman, MD; Emily S. Lundt, MS; Terry M. Therneau, PhD; et al.
free access
JAMA Neurol. 2021;78(2):217-228. doi:10.1001/jamaneurol.2020.3921
This cohort study investigates the association between 尾-amyloid in positron emission tomography and subsequent tau accumulation in persons who were cognitively unimpaired, to gain insight into the temporal associations between 尾-amyloid and tau accumulation.
Philip S. Insel, MS; Oskar Hansson, MD, PhD; Niklas Mattsson-Carlgren, MD, PhD
free access
JAMA Neurol. 2021;78(2):229-235. doi:10.1001/jamaneurol.2020.3780
This cross-sectional study used screening data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer Disease Study (A4 Study) to assess whether the presence of the apolipoprotein E 蔚2 allele is protective against 尾-amyloid accumulation in the presence of 蔚4 in individuals without cognitive impairment.