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October 2024 - July 1959

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Issue

November 2021, Vol 78, No. 11, Pages 1292-1413

Viewpoint

Aducanumab and the Business of Alzheimer Disease—Some Choice

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1303-1304. doi:10.1001/jamaneurol.2021.3123

This Viewpoint discusses why aducanumab should not have been approved by the US Food and Drug Administration.

What the Aducanumab Approval Reveals About Alzheimer Disease Research

Abstract Full Text
JAMA Neurol. 2021;78(11):1305-1306. doi:10.1001/jamaneurol.2021.3404

This Viewpoint discusses concern about inadequate representation of people from historically excluded racial and ethnic backgrounds in aducanumab clinical trials.

US Food and Drug Administration Approval of Aducanumab—Is Amyloid Load a Valid Surrogate End Point for Alzheimer Disease Clinical Trials?

Abstract Full Text
JAMA Neurol. 2021;78(11):1307-1308. doi:10.1001/jamaneurol.2021.3126

This Viewpoint discusses whether amyloid load is a valid surrogate end point for Alzheimer disease clinical trials.

On the Brain

I Only Want to See You—A Challenge of Long-term Clinician-Patient Relationships in Team-Based Clinical Care

Abstract Full Text
JAMA Neurol. 2021;78(11):1309-1310. doi:10.1001/jamaneurol.2021.3029

This essay discusses how to best preserve the mutual benefits of long-term clinician-patient relationships within a team-based care model.

Editorial

Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care?

Abstract Full Text
JAMA Neurol. 2021;78(11):1311-1313. doi:10.1001/jamaneurol.2021.2942
Original Investigation

Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1314-1323. doi:10.1001/jamaneurol.2021.3619

This cohort study describes the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis after SARS-CoV-2 vaccination with and without thrombosis with thrombocytopenia syndrome.

Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1324-1332. doi:10.1001/jamaneurol.2021.3356

This randomized clinical trial measures whether methylphenidate compared with placebo decreases the severity of apathy in individuals with Alzheimer disease.

Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis

Abstract Full Text
open access has audio
JAMA Neurol. 2021;78(11):1333-1344. doi:10.1001/jamaneurol.2021.3188

This meta-analysis evaluates the use and safety of immunotherapies among patients with N-methyl-d-aspartate receptor antibody encephalitis.

Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1345-1354. doi:10.1001/jamaneurol.2021.3310

This randomized clinical trial uses extended neurophysiological examinations to assess the ability of levetiracetam treatment to improve cognitive function among adults with Alzheimer disease with and without epileptiform activity.

Detection of Neoplasms by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1355-1366. doi:10.1001/jamaneurol.2021.3088

This case-control study evaluates the use, sensitivity, and specificity of the cerebrospinal fluid metagenomic next-generation sequencing assay in identifying aneuploidy and other large copy number variations.

Association of Enzyme-Inducing Antiseizure Drug Use With Long-term Cardiovascular Disease

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1367-1374. doi:10.1001/jamaneurol.2021.3424

This cohort study compares the risk associated with enzyme-inducing antiseizure medications and non–enzyme-inducing antiseizure medications in individuals with cardiovascular disease.

Head-to-Head Comparison of 8 Plasma Amyloid-β 42/40 Assays in Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2021;78(11):1375-1382. doi:10.1001/jamaneurol.2021.3180

This cross-sectional study compares the performance of plasma amyloid-β 42/40 (Aβ42/40) measured using 8 different Aβ assays and methods in detecting abnormal brain Aβ status in patients with early Alzheimer disease.

Review

Discerning the Role of Autoimmunity and Autoantibodies in Epilepsy: A Review

Abstract Full Text
JAMA Neurol. 2021;78(11):1383-1390. doi:10.1001/jamaneurol.2021.3113

This narrative review evaluates the literature pertaining to neural antibody frequency in epilepsy populations, highlights key findings across studies that characterize populations in which antibody positivity is more likely, and identifies gaps and limitations in the literature to clarify what directions should be considered for future clinical research in this area.

Images in Neurology

Carcinomatosis Encephalitis Secondary to Neuroendocrine Transformation of Prostate Cancer

Abstract Full Text
JAMA Neurol. 2021;78(11):1391-1392. doi:10.1001/jamaneurol.2021.3304

This case report describes a man in his 70s with a neuroendocrine carcinoma in the right frontal lobe during treatment for prostate cancer.

JAMA Neurology Clinical Challenge

Multiple Facial Ulcers Following a Stroke

Abstract Full Text
JAMA Neurol. 2021;78(11):1393-1394. doi:10.1001/jamaneurol.2021.2236

A 66-year-old man presents with multiple progressive ulcers and hypoesthesia on the right side of his face, new-onset hemiplegia and hemianopsia on the left side of his face, and ischemic posterior circulation stroke. What is your diagnosis?

Research Letter

Statewide Emergency Medical Services Protocols for Suspected Stroke and Large Vessel Occlusion

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1404-1406. doi:10.1001/jamaneurol.2021.3227

This cross-sectional study characterizes prehospital large vessel occlusion transport algorithms across the US.

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1407-1409. doi:10.1001/jamaneurol.2021.2823

This analysis compares plasma biomarkers of tau and neurodegeneration during major cardiac and noncardiac surgeries.

Rate of Recurrent Guillain-Barré Syndrome After mRNA COVID-19 Vaccine BNT162b2

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1409-1411. doi:10.1001/jamaneurol.2021.3287

This study establishes rates of Guillain-Barré syndrome relapse among Pfizer-BioNTech BNT162b2 vaccine receivers.

Comment & Response

Traumatic Brain Injury Recovery Trajectories in Patients With Disorders of Consciousness

Abstract Full Text
JAMA Neurol. 2021;78(11):1411. doi:10.1001/jamaneurol.2021.3433

Traumatic Brain Injury Recovery Trajectories in Patients With Disorders of Consciousness

Abstract Full Text
JAMA Neurol. 2021;78(11):1412. doi:10.1001/jamaneurol.2021.3436

Traumatic Brain Injury Recovery Trajectories in Patients With Disorders of Consciousness—Reply

Abstract Full Text
JAMA Neurol. 2021;78(11):1412-1413. doi:10.1001/jamaneurol.2021.3430
Correction

Error in Figure

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1413. doi:10.1001/jamaneurol.2021.3219
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2021;78(11):1292. doi:10.1001/jamaneurol.2020.3697
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