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Absolute Risk Estimates of the Association Between Concussion and Suicide | JAMA Neurology | 糖心vlog

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Comment & Response
June 10, 2019

Absolute Risk Estimates of the Association Between Concussion and Suicide

Author Affiliations
  • 1David L. MacIntosh Sport Medicine Clinic, Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, Ontario, Canada
  • 2Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
  • 3Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, Ontario, Canada
JAMA Neurol. 2019;76(7):870-871. doi:10.1001/jamaneurol.2019.1449

To the Editor Fralick and colleagues1 provide a summary and meta-analysis of the association between concussion and suicide outcomes. This study summated the evidence on suicidality following concussion, and we commend the authors on their comprehensive review. The authors reported a relative risk of suicide associated with a history of concussion of 2.03 (95% CI, 1.47-2.80; P鈥&濒迟;鈥.001).1 To our knowledge, absolute risk increases were not reported or interpreted in this article.1

There is strong support for reporting relative and absolute risks in epidemiologic studies to increase the transparency and interpretation of observed associations, particularly in studies with rare outcomes, such as suicide.2-4 Arguments have been made that relative risks cannot fully be interpreted without adjacent absolute risks,4 because relative risks can exaggerate perceptions of harm or benefit.3 A recent article proposed that absolute risks 鈥渁re transparent, while relative risks such as 鈥榯wofold鈥 provide incomplete and misleading risk information.鈥3 We recognize the limitations associated with pooling and meta-analyzing absolute risks, including the heterogeneity of baseline rates2; however, we believe that studies investigating concussion and suicide risk hold such topical relevance that comprehensive reporting of relative and absolute effect estimates is required.

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