GASTROENTEROLOGY AND HEPATOLOGY
Daniela Penz, MD; Elisabeth Waldmann, MD; Monika Hackl, PhD; et al.
This cohort study investigates the incidence of colorectal cancer and prevalence of adenomas and other precursor lesions among adults younger than 50 years in Austria.
JAMA Netw Open. 2023;6(12):e2334757. doi:10.1001/jamanetworkopen.2023.34757
HEALTH INFORMATICS
Ashwin Nayak, MD, MS; Sharif Vakili, MD, MS, MBA; Kristen Nayak, MD; et al.
This randomized clinical trial examines whether a voice-based conversational artificial intelligence (AI) application can help patients with type 2 diabetes titrate basal insulin at home to achieve rapid glycemic control.
JAMA Netw Open. 2023;6(12):e2340232. doi:10.1001/jamanetworkopen.2023.40232
INFECTIOUS DISEASES
Tobias Todsen, MD, PhD; Kathrine K. Jakobsen, MD; Mathias Peter Grønlund, MD; et al.
This randomized clinical trial compares the diagnostic accuracy of self-collected and health care worker–collected nasal and throat specimens for SARS-CoV-2 rapid antigen testing.
JAMA Netw Open. 2023;6(12):e2344295. doi:10.1001/jamanetworkopen.2023.44295
COMPLEMENTARY AND ALTERNATIVE MEDICINE
Belle Zaccari, PsyD; Melinda Higgins, PhD; Terri N. Haywood, MPH; et al.
This randomized clinical trial evaluated the effectiveness of trauma-sensitive yoga vs cognitive processing therapy for women veterans with military sexual trauma–related posttraumatic stress disorder (PTSD).
JAMA Netw Open. 2023;6(12):e2344862. doi:10.1001/jamanetworkopen.2023.44862
NEUROLOGY
Satoshi Saito, MD, PhD; Keisuke Suzuki, MD, PhD; Ryo Ohtani, MD, PhD; et al.
This randomized clinical trial investigates whether cilostazol is safe and effective for cognitive function among individuals with mild cognitive impairment.
JAMA Netw Open. 2023;6(12):e2344938. doi:10.1001/jamanetworkopen.2023.44938
CARDIOLOGY
Jose-Miguel Yamal, PhD; Journey Martinez, MS; Mikala C. Osani, MPH; et al.
This prespecified secondary analysis of a randomized clinical trial assesses the long-term posttrial risk of morbidity and mortality outcomes among participants who were randomized to a thiazide-type diuretic, calcium channel blocker, or ACE inhibitor with up to 23 years of follow-up.
JAMA Netw Open. 2023;6(12):e2344998. doi:10.1001/jamanetworkopen.2023.44998
PUBLIC HEALTH
Daniel McIntyre, PhD; Joshua G. Kovoor, MD; Clara K. Chow, PhD; et al.
This randomized clinical trial assesses whether clinician-created video-based atrial fibrillation (AF) education is feasible and improves knowledge of AF among patients treated in an outpatient clinic.
JAMA Netw Open. 2023;6(12):e2345308. doi:10.1001/jamanetworkopen.2023.45308
OPHTHALMOLOGY
Xiangyi Yu, MS; Jian Yuan, PhD; Zhen Ji Chen, PhD; et al.
This cohort study evaluates risk variants in a large high-myopia cohort and the implications of genetic testing of schoolchildren with high myopia.
JAMA Netw Open. 2023;6(12):e2345821. doi:10.1001/jamanetworkopen.2023.45821
HEMATOLOGY
Samantha J. Simon, BA; Rushad Patell, MD; Jeffrey I. Zwicker, MD; et al.
This cohort study assesses risk factors for postoperative venous thromboembolism and bleeding among patients receiving thromboprophylactic agents after total hip and knee arthroplasty.
JAMA Netw Open. 2023;6(12):e2345883. doi:10.1001/jamanetworkopen.2023.45883
HEALTH INFORMATICS
Madelena Y. Ng, DrPH, MPH; Alaa Youssef, PhD; Adam S. Miner, PsyD, MS; et al.
This qualitative study examines the perceptions of data set experts on the present status of development of artificial intelligence (AI)–ready data sets for use in machine learning research.
JAMA Netw Open. 2023;6(12):e2345892. doi:10.1001/jamanetworkopen.2023.45892
HEALTH POLICY
Jean Yoon, PhD, MHS; Ciaran S. Phibbs, PhD; Michael K. Ong, MD, PhD; et al.
This cohort study compares outcomes for 6 acute conditions in Veterans Affairs (VA) and non-VA hospitals in 11 states for veterans using VA and all-payer discharge data.
JAMA Netw Open. 2023;6(12):e2345898. doi:10.1001/jamanetworkopen.2023.45898
ONCOLOGY
Ting Martin Ma, MD, PhD; Neeraj Agarwal, MD; Brandon Mahal, MD; et al.
This cohort study uses data Surveillance, Epidemiology, and End Results–Medicare linked data to assess whether there are racial and ethnic disparities in use of novel hormonal therapy agents in patients with advance prostate cancer.
JAMA Netw Open. 2023;6(12):e2345906. doi:10.1001/jamanetworkopen.2023.45906
CARDIOLOGY
Yuan Lu, ScD; Yuntian Liu, MPH; Lovedeep Singh Dhingra, MBBS; et al.
This cross-sectional study of adults with atherosclerotic cardiovascular disease (ASCVD) compares adoption of recommended prevention guidelines and optimal care practices across racial and ethnic categories.
JAMA Netw Open. 2023;6(12):e2345964. doi:10.1001/jamanetworkopen.2023.45964
MEDICAL EDUCATION
Emily C. N. Lawrence, MD, EdM; C. Jessica Dine, MD, MSHP; Jennifer R. Kogan, MD
This qualitative study explores how and why medical students use third-party educational resources outside of their institution’s curriculum.
JAMA Netw Open. 2023;6(12):e2345971. doi:10.1001/jamanetworkopen.2023.45971
NEUROLOGY
Samantha A. Keil, PhD; Abigail G. Schindler, PhD; Marie X. Wang, PhD; et al.
This cross-sectional study evaluates the association of longitudinal sleep patterns with age-related changes in cognitive function in healthy older adults.
JAMA Netw Open. 2023;6(12):e2346006. doi:10.1001/jamanetworkopen.2023.46006
PEDIATRICS
Sarah Smith, MD, MSc; Alice Charach, MD, MSc; Teresa To, PhD; et al.
This cross-sectional study examines temporal trends in the rates of pediatric eating disorder hospitalizations by clinical and demographic characteristics in Ontario, Canada, over a 17-year period.
JAMA Netw Open. 2023;6(12):e2346012. doi:10.1001/jamanetworkopen.2023.46012
PEDIATRICS
Lu Zhang, MPH; Ping Li, MPH; Qiaoyue Ge, MPH; et al.
This cohort study investigates the association between maternal depressive symptoms and fetal growth during the critical rapid growth stage before delivery.
JAMA Netw Open. 2023;6(12):e2346018. doi:10.1001/jamanetworkopen.2023.46018
NEUROLOGY
Yiqi Lin, MD; Yongxi Wu, MMed; Qianwen Lin, MMed; et al.
This cohort study investigates whether there is an association between sleep duration and all-cause mortality among people with obstructive sleep apnea.
JAMA Netw Open. 2023;6(12):e2346085. doi:10.1001/jamanetworkopen.2023.46085
ONCOLOGY
Eric X. Chen, MD, PhD; Jonathan M. Loree, MD; Emma Titmuss, MSc; et al.
This secondary analysis of a randomized clinical trial investigates whether the presence of liver metastasis is an indicator of treatment resistance to immune checkpoint inhibitors (ICIs) in patients with advanced colorectal cancer.
JAMA Netw Open. 2023;6(12):e2346094. doi:10.1001/jamanetworkopen.2023.46094
PEDIATRICS
Winnie Wan Yee Tso, MBBS; Lok Kan Leung, MSocSc; Mathew Siu Chun Chow, MBBS; et al.
This cross-sectional study analyzes changes in mental well-being of children with special educational needs (SEN) after returning to in-person learning after COVID-19–related school closures.
JAMA Netw Open. 2023;6(12):e2346106. doi:10.1001/jamanetworkopen.2023.46106
SURGERY
Emrullah Birgin, MD; Sebastian Hempel, MD; Alina Reeg, MD; et al.
This prognostic study develops a hemorrhage risk score model to predict the development of postpancreatectomy hemorrhage in patients who undergo pancreatoduodenectomy.
JAMA Netw Open. 2023;6(12):e2346113. doi:10.1001/jamanetworkopen.2023.46113
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Invited Commentary
Toward Better Prediction of Postpancreatectomy Hemorrhage
Benjamin D. Ferguson, MD, PhD
JAMA Netw Open
PSYCHIATRY
Fen Ye, MN, RN; Jung Jae Lee, PhD, RN; Dandan Xue, MN, RN; et al.
This systematic review and meta-analysis identifies intervention characteristics of ACT that are associated with improved psychological health and assesses the acceptability of ACT among informal caregivers.
JAMA Netw Open. 2023;6(12):e2346216. doi:10.1001/jamanetworkopen.2023.46216
ONCOLOGY
Daniel S. O’Neil, MD, MPH; Yehoda M. Martei, MD, MSCE; Katherine D. Crew, MD, MS; et al.
This matched cohort study compares time to cancer treatment initiation and relative dose intensity of neoadjuvant and adjuvant chemotherapy among patients with breast cancer with vs without HIV.
JAMA Netw Open. 2023;6(12):e2346223. doi:10.1001/jamanetworkopen.2023.46223
OBSTETRICS AND GYNECOLOGY
Huiling Xu, MD, MSc; Natalie Holowko, PhD; Ingmar Näslund, MD, PhD; et al.
This cohort study examines pregnancy weight gain among women in Sweden with a history of bariatric surgery vs those without and investigates whether pregnancy weight gain differs by surgical procedure, surgery-to-conception interval, and/or surgery-to-conception weight loss.
JAMA Netw Open. 2023;6(12):e2346228. doi:10.1001/jamanetworkopen.2023.46228
DIABETES AND ENDOCRINOLOGY
Margaret F. Zupa, MD, MS; Varsha G. Vimalananda, MD, MPH; Scott D. Rothenberger, PhD; et al.
This cohort study evaluates patterns of telemedicine use and their association with glycemic control among adults receiving endocrinology care for type 2 diabetes.
JAMA Netw Open. 2023;6(12):e2346305. doi:10.1001/jamanetworkopen.2023.46305
OBSTETRICS AND GYNECOLOGY
Lauren M. Kucirka, MD, PhD; Ana M. Angarita, MD; Tracy A. Manuck, MD, MS; et al.
This cohort study evaluates characteristics and clinical outcomes of patients with pregnancy-related end-stage kidney disease.
JAMA Netw Open. 2023;6(12):e2346314. doi:10.1001/jamanetworkopen.2023.46314
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Invited Commentary
Uncovering the Role of Kidney Disease and Its Care in the US Maternal Health Equity Crisis
Dinushika Mohottige, MD, MPH; L. Ebony Boulware, MD, MPH
JAMA Netw Open
PUBLIC HEALTH
Cora Peterson, PhD; Maria V. Aslam, PhD; Phyllis H. Niolon, PhD; et al.
This economic evaluation evaluates the economic burden associated with adverse childhood experiences in adults.
JAMA Netw Open. 2023;6(12):e2346323. doi:10.1001/jamanetworkopen.2023.46323
CARDIOLOGY
Odeya Barayev, MD, MBA; Chelsea E. Hawley, PharmD, MPH; Helen Wellman, ScD; et al.
This cohort study uses target trail emulation to evaluate the association of statin use with all-cause mortality and major adverse cardiovascular events among US veterans older than 65 years with chronic kidney disease stages 3 to 4.
JAMA Netw Open. 2023;6(12):e2346373. doi:10.1001/jamanetworkopen.2023.46373
GASTROENTEROLOGY AND HEPATOLOGY
Jihane N. Benhammou, MD, PhD; Mei Leng, MS, MD; Shailja C. Shah, MD, MPH; et al.
This cohort study assessed the association of exposure to Agent Orange and hepatocellular carcinoma among Vietnam veterans.
JAMA Netw Open. 2023;6(12):e2346380. doi:10.1001/jamanetworkopen.2023.46380
EQUITY, DIVERSITY, AND INCLUSION
Wafa Khadraoui, MD; Caitlin E. Meade, BS; Floor J. Backes, MD; et al.
This cohort study examines the association of race and ethnicity with clinical trial enrollment among women with endometrial, ovarian, or cervical cancer.
JAMA Netw Open. 2023;6(12):e2346494. doi:10.1001/jamanetworkopen.2023.46494
EQUITY, DIVERSITY, AND INCLUSION
Félix Camirand-Lemyre, PhD; Laura Merson; Bharath Kumar Tirupakuzhi Vijayaraghavan, MD, MSc; et al.
This large cohort study assesses variations over time and across World Health Organization geographic regions for the use of corticosteroids in treating patients with severe or critical COVID-19.
JAMA Netw Open. 2023;6(12):e2346502. doi:10.1001/jamanetworkopen.2023.46502
CRITICAL CARE MEDICINE
Andrew G. Wu, MD, MPH; Gowri Madhavan, MPH; Kathy Deakins, RRT, NPS; et al.
This quality improvement study reports the outcome associated with implementing a multidisciplinary apparent cause analysis, daily discussion of extubation readiness, and daily discussion of fluid balance goals in hospital intensive care units.
JAMA Netw Open. 2023;6(12):e2346545. doi:10.1001/jamanetworkopen.2023.46545
GLOBAL HEALTH
Elroy Boers, PhD; Meredith Barrett, PhD; Jason G. Su, PhD; et al.
This modeling study assesses the global burden of chronic obstructive pulmonary disease through 2050.
JAMA Netw Open. 2023;6(12):e2346598. doi:10.1001/jamanetworkopen.2023.46598
PEDIATRICS
Myrian Sze Nga Fan, MSc, BSN, RN; William Ho Cheung Li, PhD, MPhil, BN, RN; Laurie Long Kwan Ho, PhD, MPhil, BN, RN; et al.
This systematic review and meta-analysis assesses the available evidence on the associations of nature-based interventions with health-related functional outcomes among children with autism spectrum disorder.
JAMA Netw Open. 2023;6(12):e2346715. doi:10.1001/jamanetworkopen.2023.46715
NEUROLOGY
Marc Cicero Schubert; Wolfgang Wick, MD; Varun Venkataramani, MD, PhD
This cross-sectional study assesses the performance of large language models (LLMs) on neurology board–style examinations.
JAMA Netw Open. 2023;6(12):e2346721. doi:10.1001/jamanetworkopen.2023.46721
EMERGENCY MEDICINE
Alexander T. Janke, MD, MHS; Courtney W. Mangus, MD; Christopher M. Fung, MD, MS; et al.
This cohort study describes wait times, lengths of stay, and revisits for pediatric patients with acute viral and respiratory conditions presenting at Michigan emergency departments (EDs) during a surge of visits in 2022.
JAMA Netw Open. 2023;6(12):e2346769. doi:10.1001/jamanetworkopen.2023.46769
PEDIATRICS
Yaakov Ophir, PhD; Hananel Rosenberg, PhD; Refael Tikochinski, MA; et al.
This systematic review and meta-analysis examines the association between screen time and autism spectrum disorder.
JAMA Netw Open. 2023;6(12):e2346775. doi:10.1001/jamanetworkopen.2023.46775
INFECTIOUS DISEASES
Pandora L. Wander, MD, MS; Aaron Baraff, PhD; Alexandra Fox, MSIS; et al.
This cohort study assesses the rates, risk factors, clinical setting, and symptoms associated with the documentation of International Statistical Classification of Diseases, Tenth Revision (ICD-10) code U09.9 for post–COVID-19 condition among US veterans with positive test results for SARS-CoV-2.
JAMA Netw Open. 2023;6(12):e2346783. doi:10.1001/jamanetworkopen.2023.46783
PUBLIC HEALTH
Margaret Byrne, PhD; Rayner Kay Jin Tan, PhD; Dan Wu, PhD; et al.
This systematic review and meta-analysis investigates associations between prosocial interventions and health outcomes as well as barriers to and facilitators of such interventions.
JAMA Netw Open. 2023;6(12):e2346789. doi:10.1001/jamanetworkopen.2023.46789
PEDIATRICS
Michael Khoury, MD; Ashraf S. Harahsheh, MD; Geetha Raghuveer, MD; et al.
This cohort study examines the prevalence of obesity and its association with clinical outcomes in children with Kawasaki disease and multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.
JAMA Netw Open. 2023;6(12):e2346829. doi:10.1001/jamanetworkopen.2023.46829
GLOBAL HEALTH
Dennis L. Chao, PhD; Ahmed M. Arzika, MS; Amza Abdou, MD; et al.
This secondary analysis of a cluster randomized trial examines the association among distance to primary health centers, child mortality, and the effectiveness of azithromycin mass drug administration at the community level.
JAMA Netw Open. 2023;6(12):e2346840. doi:10.1001/jamanetworkopen.2023.46840
NUTRITION, OBESITY, AND EXERCISE
Pasquale E. Rummo, PhD, MPH; Tod Mijanovich, PhD; Erilia Wu, MPA; et al.
This cohort study examines whether labeling menus with nutrition information is associated with calories purchased at a US fast food chain.
JAMA Netw Open. 2023;6(12):e2346851. doi:10.1001/jamanetworkopen.2023.46851
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Invited Commentary
Restaurant Calorie Labeling and Changes in Consumer Behavior
Christina A. Roberto, PhD; Joshua Petimar, ScD
JAMA Netw Open
ETHICS
Paula Aristizabal, MD, MAS; Shilpa Nataraj, MD; Arissa K. Ma, MD; et al.
This cross-sectional study investigates associations of social determinants of health (SDOH) and sociocontextual factors with informed consent comprehension in among parents enrolling their child with newly diagnosed cancer into a therapeutic clinical trial.
JAMA Netw Open. 2023;6(12):e2346858. doi:10.1001/jamanetworkopen.2023.46858
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Invited Commentary
Opportunities to Advance Equity Through Informed Consent Discussions
Puja J. Umaretiya, MD, MS; Emily E. Johnston, MD, MS
JAMA Netw Open
PUBLIC HEALTH
Sadiya S. Khan, MD, MSc; Adam S. Vaughan, PhD; Katharine Harrington, MPH; et al.
This cross-sectional study examines US county-level variation and trends in preterm birth rates from 2007 to 2019.
JAMA Netw Open. 2023;6(12):e2346864. doi:10.1001/jamanetworkopen.2023.46864
CRITICAL CARE MEDICINE
Glauco A. Westphal, MD, PhD; Caroline Cabral Robinson, PT, PhD; Natalia Elis Giordani, PhD; et al.
This cluster randomized clinical trial evaluates the use of a clinical management checklist and incidence of cardiac arrest in brain-dead potential organ donors in Brazil.
JAMA Netw Open. 2023;6(12):e2346901. doi:10.1001/jamanetworkopen.2023.46901
MEDICAL EDUCATION
Kelsey West, MD; Leen Oyoun Alsoud, MSc; Kathryn Andolsek, MD, MPH; et al.
This cross-sectional study evaluates whether the presence of diversity language in the mission statements of medical schools accredited since 2000 is associated with increased racial and ethnic diversity in the student body.
JAMA Netw Open. 2023;6(12):e2346916. doi:10.1001/jamanetworkopen.2023.46916
PUBLIC HEALTH
Isabel Cristina Martins Emmerick, PhD; Mônica Rodrigues Campos, PhD; Debora Castanheira, PhD; et al.
This comparative effectiveness research study examines whether the US Preventive Services Task Force (USPSTF) 2021 recommendations are more effective than the USPSTF 2013 criteria in reducing sociodemographic disparities in lung cancer death risk in Brazil.
JAMA Netw Open. 2023;6(12):e2346994. doi:10.1001/jamanetworkopen.2023.46994
PUBLIC HEALTH
Xiaotong Li, MD; Lihua Li, PhD; Wen Qin, PhD; et al.
This cohort study evaluates the association of urbanization with risk of myopia and myopia progression and with myopia severity in elementary school students.
JAMA Netw Open. 2023;6(12):e2346999. doi:10.1001/jamanetworkopen.2023.46999
PHARMACY AND CLINICAL PHARMACOLOGY
MiloÅ¡ D. Miljković, MD; Jordan Tuia, BA; Timothée Olivier, MD; et al.
This cross-sectional study assesses US Food and Drug Administration anticancer drug approvals over 6 years in terms of cost and novelty in mechanism of action.
JAMA Netw Open. 2023;6(12):e2347006. doi:10.1001/jamanetworkopen.2023.47006
EQUITY, DIVERSITY, AND INCLUSION
Hairui Yu, PhD; Nicole Armstrong, PhD; Greg Pavela, PhD; et al.
This cross-sectional study investigates sex differences in the association between FTO single-nucleotide variants and obesity traits among self-identified non-Hispanic Black and non-Hispanic White US adults.
JAMA Netw Open. 2023;6(12):e2347171. doi:10.1001/jamanetworkopen.2023.47171
ONCOLOGY
Lijie Wang, PhD; Yue Qi, MS; Ailing Liu, MD; et al.
This cohort study evaluates the association of opportunistic low-dose computed tomography (LDCT) screening with improved prognosis of adults with lung cancer in mainland China.
JAMA Netw Open. 2023;6(12):e2347176. doi:10.1001/jamanetworkopen.2023.47176
GERIATRICS
Kali S. Thomas, PhD; Jen Bunker, MPH; Emily Gadbois, PhD; et al.
This randomized clinical trial analyzes whether 2 predominant modes of home-delivered meals differentially delay nursing home placement for older adults who are homebound with self-reported dementia.
JAMA Netw Open. 2023;6(12):e2347195. doi:10.1001/jamanetworkopen.2023.47195
CARDIOLOGY
Essa Hariri, MD, MSc; Milad Matta, MD; Habib Layoun, MD, MS; et al.
This cohort study evaluates the association of acetylsalicylic acid use with aneurysm progression and long-term clinical outcomes in patients with abdominal aortic aneurysm.
JAMA Netw Open. 2023;6(12):e2347296. doi:10.1001/jamanetworkopen.2023.47296
PUBLIC HEALTH
Nicole L. Hair, PhD; Carly Urban, PhD
This cohort study examines associations between COVID-19 outcomes, pandemic-related economic hardship, and prepandemic socioeconomic status among families in the US.
JAMA Netw Open. 2023;6(12):e2347318. doi:10.1001/jamanetworkopen.2023.47318
OBSTETRICS AND GYNECOLOGY
Yong-Soo Seo, MD, PhD; Jin-Sung Yuk, MD, PhD
This cohort study assesses osteoporosis and fracture risk among female patients in Korea who underwent hysterectomy due to benign conditions.
JAMA Netw Open. 2023;6(12):e2347323. doi:10.1001/jamanetworkopen.2023.47323
SUBSTANCE USE AND ADDICTION
Xiaozhong Wen, MD, PhD; Lufeiya Liu, BA; Aye A. Moe, BS; et al.
This cohort study uses data from the Pregnancy Risk Assessment Monitoring System to examine yearly trends, sociodemographic and pregnancy-related determinants, and the association with small-for-gestational-age birth of e-cigarette and/or cigarette use during late pregnancy among adolescents.
JAMA Netw Open. 2023;6(12):e2347407. doi:10.1001/jamanetworkopen.2023.47407
PEDIATRICS
Joaquim Vidiella-Martin, PhD; Jasper V. Been, PhD
This cross-sectional study of live births in the Netherlands examines the associations between migration background and infant mortality.
JAMA Netw Open. 2023;6(12):e2347444. doi:10.1001/jamanetworkopen.2023.47444
PEDIATRICS
Timothy J. D. Ohlsen, MD, MS; Yan Chen, MS; Laura-Mae Baldwin, MD, MPH; et al.
This cross-sectional study examines screening and health care utilization rates among survivors of childhood cancer at high risk for cardiovascular complications.
JAMA Netw Open. 2023;6(12):e2347449. doi:10.1001/jamanetworkopen.2023.47449
ONCOLOGY
Hakyoung Kim, MD; Tae In Yoon, MD; Seonok Kim, MSc; et al.
This cohort study compares the cumulative incidence and peak occurrence period of contralateral breast cancer between patients aged 35 years or younger and those older than 35 years at the time of surgery for primary breast cancer.
JAMA Netw Open. 2023;6(12):e2347511. doi:10.1001/jamanetworkopen.2023.47511
EQUITY, DIVERSITY, AND INCLUSION
Amrita Mukhopadhyay, MD; Saul Blecker, MD; Xiyue Li, MS; et al.
This cohort study examines the association between neighborhood-level socioeconomic status and medication nonadherence among patients with heart failure (HF).
JAMA Netw Open. 2023;6(12):e2347519. doi:10.1001/jamanetworkopen.2023.47519
MEDICAL EDUCATION
Catherine Havemann, MD; Hyacinth R. C. Mason, PhD, MPH; Regina G. Russell, PhD, MA, MEd; et al.
This qualitative study explores challenges that first-generation students experience in medical education and identifies opportunities to improve foundational first-generation support.
JAMA Netw Open. 2023;6(12):e2347528. doi:10.1001/jamanetworkopen.2023.47528
STATISTICS AND RESEARCH METHODS
Pascal Geldsetzer, PhD; Markus Heemann, PhD; Pauli Tikka, PhD; et al.
This cross-sectional study examines the prevalence of very short peer reviews (<200 words) from 3 general medical journals as a measure of peer review quality.
JAMA Netw Open. 2023;6(12):e2347607. doi:10.1001/jamanetworkopen.2023.47607
PUBLIC HEALTH
Tim A. Bullman, MA; Fatema Z. Akhtar, MS; Sybil W. Morley, MPH; et al.
This cohort study examines the incidence and patterns of suicide from 1979 to 2019 among veterans who were deployed to the Vietnam War and veterans who served in the military at that time but were not deployed to the Vietnam War.
JAMA Netw Open. 2023;6(12):e2347616. doi:10.1001/jamanetworkopen.2023.47616
PEDIATRICS
Yujiao Deng, PhD; Zichen Zhang, BA; Yiding Gui, BA; et al.
This cohort study examines how the natural history of sleep disturbances is associated with resolved and incident emotional and behavioral difficulties among preschool-aged children in Shanghai, China.
JAMA Netw Open. 2023;6(12):e2347623. doi:10.1001/jamanetworkopen.2023.47623
DIABETES AND ENDOCRINOLOGY
Mats C. Højbjerg Lassen, MD; Niklas Dyrby Johansen, MD; Muthiah Vaduganathan, MD, MPH; et al.
This secondary analysis of a randomized clinical trial assesses the effect of influenza vaccination booster nudges on influenza vaccination uptake in patients with vs without diabetes.
JAMA Netw Open. 2023;6(12):e2347630. doi:10.1001/jamanetworkopen.2023.47630
PSYCHIATRY
Jae Han Kim; JaeSeong Hong, BBA; Hangnyoung Choi, MD; et al.
This diagnostic study examines the potential of deep ensemble models to screen for autism spectrum disorder and symptom severity using retinal photographs.
JAMA Netw Open. 2023;6(12):e2347692. doi:10.1001/jamanetworkopen.2023.47692
ONCOLOGY
Tomohiro Sakamoto, MD, PhD; Taichi Matsubara, MD, PhD; Takayuki Takahama, MD, PhD; et al.
This multicenter cohort study investigates the status of biomarker testing and drug therapy for non–small cell lung cancer (NSCLC) in Japan to identify problems in lung cancer treatment.
JAMA Netw Open. 2023;6(12):e2347700. doi:10.1001/jamanetworkopen.2023.47700
MEDICAL EDUCATION
Daniel Majerczyk, PharmD; Erin M. Behnen, PharmD; David J. Weldon, PhD; et al.
This cross-sectional study examines the diversity of students in health profession programs with an emphasis on the trends of underrepresented minority groups and sex relative to the overall age-adjusted US population.
JAMA Netw Open. 2023;6(12):e2347817. doi:10.1001/jamanetworkopen.2023.47817
SURGERY
Lisa M. McElroy, MD, MS; Tyler Schappe, MS; Dinushika Mohottige, MD, MPH; et al.
This cohort study examines racial equity among living donor kidney transplant recipients by the characteristics and catchment areas of transplant centers.
JAMA Netw Open. 2023;6(12):e2347826. doi:10.1001/jamanetworkopen.2023.47826
ORTHOPEDICS
Jessica M. Welch, BS; Giselle I. Gomez, BA; Maya Chatterjee, MSc; et al.
This qualitative study uses mixed methods to examine contextual determinants, such as site-specific barriers and facilitators, of time to surgery for patients with hip fracture across diverse hospitals.
JAMA Netw Open. 2023;6(12):e2347834. doi:10.1001/jamanetworkopen.2023.47834
ANESTHESIOLOGY
Nan Song, MD; Yi Yang, MD; Zhong Zheng, MD; et al.
This randomized clinical trial assesses whether esketamine as an adjuvant to propofol sedation leads to a reduced incidence of desaturation and hypotension during endoscopic procedures.
JAMA Netw Open. 2023;6(12):e2347886. doi:10.1001/jamanetworkopen.2023.47886
OCCUPATIONAL HEALTH
Jennifer A. Ligibel, MD; Nicolette Goularte, PhD; Jennifer I. Berliner, MD; et al.
This cross-sectional study describes the prevalence of burnout, professional fulfillment, and intention to leave among physicians at academic-affiliated health care systems and identifies institutional and individual factors associated with intention to leave.
JAMA Netw Open. 2023;6(12):e2347894. doi:10.1001/jamanetworkopen.2023.47894
HEMATOLOGY
Aaron N. Winn, PhD; Ehab Atallah, MD; Jorge Cortes, MD; et al.
This decision analytical modeling study estimates the financial outcome of discontinuation of tyrosine kinase inhibitor (TKI) therapy among US adult patients with chronic myeloid leukemia (CML) who experience deep molecular response to TKIs.
JAMA Netw Open. 2023;6(12):e2347950. doi:10.1001/jamanetworkopen.2023.47950
ONCOLOGY
Andrea Necchi, MD; Philippe E. Spiess, MD, MS; Tiago Costa de Padua, MD; et al.
This cohort study uses data from a nationwide database to characterize biomarker features and immune checkpoint inhibitor therapy outcomes associated with tumor mutational burden among patients with advanced metastatic penile squamous cell carcinoma.
JAMA Netw Open. 2023;6(12):e2348002. doi:10.1001/jamanetworkopen.2023.48002
UROLOGY
Saira Khan, PhD, MPH; Su-Hsin Chang, PhD, MS; Mei Wang, MS; et al.
This cohort study of veterans with advanced prostate cancer assesses the prevalence of treatment-related adverse effects and their association with local vs nonlocal treatment.
JAMA Netw Open. 2023;6(12):e2348057. doi:10.1001/jamanetworkopen.2023.48057
CARDIOLOGY
John W. Davis, BA; Susan C. Weller, PhD; Laura Porterfield, MD; et al.
This case control study analyzes whether statins are associated with decreased risk of venous thromboembolism among perimenopausal women receiving hormone therapy.
JAMA Netw Open. 2023;6(12):e2348213. doi:10.1001/jamanetworkopen.2023.48213
INFECTIOUS DISEASES
Hiroyuki Suzuki, MD, MSCI; Ian Kidder, MD, MS; Tomohiro Tanaka, MD, MPH; et al.
This cohort study examines the incidence of colorectal cancer in patients with a previous diagnosis of pyogenic liver disease.
JAMA Netw Open. 2023;6(12):e2348218. doi:10.1001/jamanetworkopen.2023.48218
HEALTH POLICY
Anna M. Morenz, MD; Jonathan Staloff, MD, MSc; Joshua M. Liao, MD, MSc; et al.
This cohort study describes early trends in the use of new audio-only telemedicine claims modifiers 93 and FQ in Washington State, which were introduced to improve the designation and identification of audio-only telemedicine claims.
JAMA Netw Open. 2023;6(12):e2348224. doi:10.1001/jamanetworkopen.2023.48224
EQUITY, DIVERSITY, AND INCLUSION
Adela Wu, MD; Karleen F. Giannitrapani, PhD; Ariadna Garcia, MS; et al.
This cross-sectional study assesses the association of race, ethnicity, and other factors, including history of mental health disability, with disparities in preoperative goals of care documentation among a population of patients of the Veterans Healthcare Administration.
JAMA Netw Open. 2023;6(12):e2348235. doi:10.1001/jamanetworkopen.2023.48235
PUBLIC HEALTH
Nayili Mahemuti, MBBS; Jiao Zou, MBBS; Chuanlang Liu, MBBS; et al.
This cohort study investigates the association of a high urinary albumin-to-creatinine ratio within the normal range and cardiovascular health with all-cause mortality in US adults.
JAMA Netw Open. 2023;6(12):e2348333. doi:10.1001/jamanetworkopen.2023.48333
PSYCHIATRY
Dea Garic, PhD; Robert C. McKinstry, MD, PhD; Joshua Rutsohn, MS, MPH; et al.
This cohort study examines the prevalence of enlarged perivascular spaces in infants who develop autism compared with controls and trajectories of extra-axial cerebrospinal fluid volume and sleep problems in later childhood.
JAMA Netw Open. 2023;6(12):e2348341. doi:10.1001/jamanetworkopen.2023.48341
CARDIOLOGY
Mackensie Yore, MD, MS; Adam Sharp, MD, MSc; Yi-Lin Wu, MS; et al.
This cohort study compares health outcomes and resource use among emergency department patients undergoing cardiac risk stratification with a HEART (History, Electrocardiogram, Age, Risk Factors, and Troponin) pathway using conventional vs high-sensitivity serum troponin.
JAMA Netw Open. 2023;6(12):e2348351. doi:10.1001/jamanetworkopen.2023.48351
SURGERY
Mathilde Nejrup Hemmingsen, MD; Anne Karen Bennedsen, MD; Randa Bismark Kullab, BMSc; et al.
This cohort study evaluates how long locally applied gentamicin, cefazolin, and vancomycin concentrations in the breast implant pocket remain above the minimum inhibitory concentration for the most common bacterial infections and measures systemic uptake.
JAMA Netw Open. 2023;6(12):e2348414. doi:10.1001/jamanetworkopen.2023.48414
HEALTH POLICY
Alaa Youssef, PhD; Madelena Y. Ng, DrPH, MPH; Jin Long, PhD; et al.
This qualitative study examines issues identified by representatives from different health sector organizations on the development of artificial intelligence and sharing of health data.
JAMA Netw Open. 2023;6(12):e2348422. doi:10.1001/jamanetworkopen.2023.48422
DIABETES AND ENDOCRINOLOGY
Fu-Shun Yen, MD; James Cheng-Chung Wei, PhD; Teng-Shun Yu, MS; et al.
This cohort study assesses the association of sodium-glucose cotransporter 2 inhibitors vs other second-line glucose-lowering medications with the development and incidence of diabetic retinopathy in adults with type 2 diabetes in Taiwan.
JAMA Netw Open. 2023;6(12):e2348431. doi:10.1001/jamanetworkopen.2023.48431
PSYCHIATRY
Mengping Zhou, MSc; Henrik Larsson, PhD; Brian M. D’Onofrio, PhD; et al.
This population-based cohort study estimates associations between general and specific psychopathology factors in parents and a wide range of register-based outcomes in their offspring.
JAMA Netw Open. 2023;6(12):e2348439. doi:10.1001/jamanetworkopen.2023.48439
PHARMACY AND CLINICAL PHARMACOLOGY
Donovan T. Maust, MD, MS; Kierstdea Petzold, MS; Julie Strominger, MS; et al.
This comparative effectiveness study of US adults receiving long-term treatment with benzodiazepines examines the association of treatment discontinuation with mortality and adverse events related to addiction and mental health.
JAMA Netw Open. 2023;6(12):e2348557. doi:10.1001/jamanetworkopen.2023.48557
DIABETES AND ENDOCRINOLOGY
Shalender Bhasin, MB, BS; Thomas G. Travison, PhD; Karol M. Pencina, PhD; et al.
This randomized clinical trial examines the effects of testosterone replacement therapy on major adverse cardiovascular events in men with hypogonadism.
JAMA Netw Open. 2023;6(12):e2348692. doi:10.1001/jamanetworkopen.2023.48692
ETHICS
Neil Millar, PhD; Bojan Batalo, PhD; Brian Budgell, PhD
This cross-sectional study of medical journal article abstracts from studies funded by the National Institutes of Health examines trends in the use of hype adjectives to promote the importance of study findings.
JAMA Netw Open. 2023;6(12):e2348706. doi:10.1001/jamanetworkopen.2023.48706
ONCOLOGY
Paola Zagami, MD; Aranzazu Fernandez-Martinez, MD, PhD; Naim U. Rashid, PhD; et al.
This cohort study assesses whether PIK3CA mutations among patients with ERBB2/HER2-positive early breast cancer are associated with treatment response and outcome, and if these associations vary by hormone receptor status or intrinsic molecular subtype.
JAMA Netw Open. 2023;6(12):e2348814. doi:10.1001/jamanetworkopen.2023.48814
PEDIATRICS
Allison N. J. Lyle, MD, MA; Henna Shaikh, MD; Ellie Oslin, BA; et al.
This systematic review describes the race and ethnicity of infants included in a sample of recent US neonatal clinical trials and the variability in this reporting.
JAMA Netw Open. 2023;6(12):e2348882. doi:10.1001/jamanetworkopen.2023.48882
HEALTH POLICY
Asiya Validova, PhD; Douglas Strane, MPH; Meredith Matone, DrPH, MHS; et al.
This cross-sectional study examines the prevalence of underinsurance across categories of child medical complexity and the variation in underinsurance within these categories across levels of household income.
JAMA Netw Open. 2023;6(12):e2348890. doi:10.1001/jamanetworkopen.2023.48890
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Invited Commentary
Addressing Underinsurance for Children With Special Health Care Needs
Jennifer K. Saper, MD, MS; Matthew M. Davis, MD, MAPP; Kristin Kan, MD, MPH, MSc
JAMA Netw Open
STATISTICS AND RESEARCH METHODS
Tales Imbiriba, PhD; Ahmet Demirkaya, MS; Ashutosh Singh, MS; et al.
This prognostic study investigates the use of wearable biosensors and machine learning for predicting aggressive behaviors in youths with autism who are psychiatric inpatients.
JAMA Netw Open. 2023;6(12):e2348898. doi:10.1001/jamanetworkopen.2023.48898
-
Invited Commentary
Wearable Technology—Another Tool in the Assessment and Treatment of Challenging Behavior Toolbox
Margaret R. Gifford, PhD, BCBA-D; Maria G. Valdovinos, PhD, BCBA-D
JAMA Netw Open
EQUITY, DIVERSITY, AND INCLUSION
Dinushika Mohottige, MD, MPH; Clemontina A. Davenport, PhD; Nrupen Bhavsar, PhD; et al.
This cross-sectional study examines associations of structural racism indicators with neighborhood prevalence of chronic kidney disease, diabetes, and hypertension in 150 neighborhoods in Durham County, North Carolina.
JAMA Netw Open. 2023;6(12):e2348914. doi:10.1001/jamanetworkopen.2023.48914
EQUITY, DIVERSITY, AND INCLUSION
S. Peter Wu, MD; Sara H. Keshavjee, MD; Sam S. Yoon, MD; et al.
This cohort study evaluates the differences in outcomes by race and ethnicity of patients with noncardia gastric cancer undergoing surgical procedures with and without neoadjuvant therapy.
JAMA Netw Open. 2023;6(12):e2349026. doi:10.1001/jamanetworkopen.2023.49026
PSYCHIATRY
Jessica Dodge, PhD; Kathrine Sullivan, PhD; Peter P. Grau, PhD; et al.
This cohort study evaluates whether participation in family therapy is associated with an increased likelihood of completing individual trauma-focused treatment among US veterans with posttraumatic stress disorder.
JAMA Netw Open. 2023;6(12):e2349098. doi:10.1001/jamanetworkopen.2023.49098
SUBSTANCE USE AND ADDICTION
Liying Chen, MS; Sheba Sethi, MD; Cara Poland, MD, MEd; et al.
This cohort study evaluates the association between Michigan Opioid Collaborative service use and county-level temporal trends of density of buprenorphine prescribers and patients receiving buprenorphine.
JAMA Netw Open. 2023;6(12):e2349103. doi:10.1001/jamanetworkopen.2023.49103
PEDIATRICS
Andrea K. Bowe, MB, MPH; Gordon Lightbody, PhD; Anthony Staines, MB, PhD; et al.
This prognostic study of very preterm infants assesses the use of an explainable algorithm to predict cognitive delay in infants at 2 years of age.
JAMA Netw Open. 2023;6(12):e2349111. doi:10.1001/jamanetworkopen.2023.49111
NEUROLOGY
Andrew M. Bryant, PhD; Nathan B. Rose, BS; Nancy R. Temkin, PhD; et al.
This cohort study examines the prevalence and characteristics of cognitive impairment and decline at 6 months after traumatic brain injury (TBI) among patients seen at level I trauma centers.
JAMA Netw Open. 2023;6(12):e2349118. doi:10.1001/jamanetworkopen.2023.49118
EQUITY, DIVERSITY, AND INCLUSION
Hannah C. Decker, MD; Laura A. Graham, PhD; Ashley Titan, MD; et al.
This cohort study examines the association between housing status and outcomes among veterans receiving care from the US Department of Veterans Affairs health system for colorectal, breast, or lung cancer.
JAMA Netw Open. 2023;6(12):e2349143. doi:10.1001/jamanetworkopen.2023.49143
NEUROLOGY
Yanzhi Li, PhD; Wanxin Wang, PhD; Liwan Zhu, PhD; et al.
This cohort study explores the association between pet ownership and rates of cognitive decline, the interaction between pet ownership and living alone, and the extent to which pet ownership mitigates the association between living alone and cognitive decline in older adults.
JAMA Netw Open. 2023;6(12):e2349241. doi:10.1001/jamanetworkopen.2023.49241
PUBLIC HEALTH
Jiyeon Oh, MD; Myeongcheol Lee, MS; Hojae Lee, MS; et al.
This cross-sectional study examines whether the COVID-19 pandemic was associated with changes in handwashing and toothbrushing frequency among South Korean adolescents.
JAMA Netw Open. 2023;6(12):e2349249. doi:10.1001/jamanetworkopen.2023.49249
PUBLIC HEALTH
Liulu Pan, MS; Bin Gao, MD; Junpeng Zhu, MD; et al.
This cohort study examines associations of negative wealth shock with cognitive decline and incident dementia in middle-aged and older adults in the US.
JAMA Netw Open. 2023;6(12):e2349258. doi:10.1001/jamanetworkopen.2023.49258
PSYCHIATRY
Parvati Singh, PhD; Saira Nawaz, PhD; Eric E. Seiber, PhD; et al.
This cohort study examines the monthly pattern of emergency department (ED) visits for schizophrenia spectrum disorders during the COVID-19 pandemic across 5 large University of California Health Systems campuses.
JAMA Netw Open. 2023;6(12):e2349305. doi:10.1001/jamanetworkopen.2023.49305
HEALTH POLICY
Lauren Lapointe-Shaw, MD, PhD; Christine Salahub, PhD; Peter C. Austin, PhD; et al.
This cross-sectional study investigates differences in rates of emergency department use among patients who had virtual visits with their own vs outside family physicians.
JAMA Netw Open. 2023;6(12):e2349452. doi:10.1001/jamanetworkopen.2023.49452
HEALTH POLICY
Meghan Bellerose, MPH; Jamie R. Daw, PhD; Maria W. Steenland, ScD, MPH
This cross-sectional study investigates the association of transitions in health care coverage with disagreement in postpartum visit use in self-reports and Medicaid claims.
JAMA Netw Open. 2023;6(12):e2349457. doi:10.1001/jamanetworkopen.2023.49457
CARDIOLOGY
Fen Yang, MD, MSc; Imre Janszky, MD, PhD; Nathalie Roos, MD, PhD; et al.
This cohort study examines the risk of ischemic heart disease and stroke in adults who were exposed to prenatal stress when their mothers experienced the death of a close family member.
JAMA Netw Open. 2023;6(12):e2349463. doi:10.1001/jamanetworkopen.2023.49463
NEPHROLOGY
Jiayi Yan, MD, PhD; Xiaoqian Yang, MD, PhD; Jieying Wang, MD; et al.
This cohort study evaluates associations of overweight or obesity and metabolic disorders with graft function decline in adult recipients of kidney transplant in China.
JAMA Netw Open. 2023;6(12):e2349538. doi:10.1001/jamanetworkopen.2023.49538
INFECTIOUS DISEASES
Lindsay N. Taylor, MD, MS; Brigid M. Wilson, PhD; Mriganka Singh, MD; et al.
This survey study evaluates whether providing nursing home clinicians with a urinary antibiogram improves empirical antibiotic treatment of urinary tract infections.
JAMA Netw Open. 2023;6(12):e2349544. doi:10.1001/jamanetworkopen.2023.49544
NUTRITION, OBESITY, AND EXERCISE
Binkai Liu, MS; Yang Hu, ScD; Sharan K. Rai, PhD; et al.
This cohort study examines associations of 5 low-carbohydrate diets including macronutrients of differing source and quality with weight change among US adults.
JAMA Netw Open. 2023;6(12):e2349552. doi:10.1001/jamanetworkopen.2023.49552
PEDIATRICS
Frederick Dun-Dery, PhD, MPhil; Jianling Xie, MD, MPH; Kathleen Winston, MSc; et al.
This cohort study evaluates the prevalence of post–COVID-19 condition among children tested for SARS-CoV-2 infection in pediatric emergency departments in Canada.
JAMA Netw Open. 2023;6(12):e2349613. doi:10.1001/jamanetworkopen.2023.49613
HEALTH POLICY
Trista M. Benítez, MPH; Zhongzhe Ouyang, MS; Alexander N. Khouri, MD; et al.
This cohort study investigates whether age-related Medicare eligibility is associated with racial and ethnic disparities in the decision to use surgical management for distal radius fracture.
JAMA Netw Open. 2023;6(12):e2349621. doi:10.1001/jamanetworkopen.2023.49621
PSYCHIATRY
Charles M. Morin, PhD; Si-Jing Chen, PhD; Hans Ivers, PhD; et al.
This randomized clinical trial compares the efficacy of behavioral therapy and zolpidem as initial therapies for improving daytime functions among patients with insomnia and evaluates the added value of a second treatment for patients whose insomnia has not remitted.
JAMA Netw Open. 2023;6(12):e2349638. doi:10.1001/jamanetworkopen.2023.49638
ONCOLOGY
Beverly Kyalwazi, MD; Christina Yau, PhD; Michael J. Campbell, PhD; et al.
This cohort study evaluates pathologic complete response and distant recurrence–free survival of early breast cancer by race and whether gene expression signatures correlate with outcomes.
JAMA Netw Open. 2023;6(12):e2349646. doi:10.1001/jamanetworkopen.2023.49646
NEUROLOGY
Costanza Peinkhofer, MD; Pardis Zarifkar, MD; Rune Haubo B. Christensen, PhD; et al.
This matched cohort study assesses whether long-term cognitive, psychiatric, or neurological complications among patients hospitalized for COVID-19 differ from those among patients hospitalized for other medical conditions of similar severity and from healthy controls.
JAMA Netw Open. 2023;6(12):e2349659. doi:10.1001/jamanetworkopen.2023.49659
DIABETES AND ENDOCRINOLOGY
Sungho Bea, PharmD; Han Eol Jeong, MPH, PhD; Kristian B. Filion, PhD; et al.
This cohort study investigates the outcomes of sodium-glucose cotransporter-2 inhibitor (SGLT-2i) and glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy among patients with type 2 diabetes in South Korea, by the presence or absence of nonalcoholic fatty liver disease (NAFLD).
JAMA Netw Open. 2023;6(12):e2349856. doi:10.1001/jamanetworkopen.2023.49856
PUBLIC HEALTH
Rui Tang, MS, MPH; Minghao Kou, MHS; Xuan Wang, MD, PhD; et al.
This cohort study examines whether frequency of adding salt to food as determined by self-report is associated with increased risk of chronic kidney disease (CKD).
JAMA Netw Open. 2023;6(12):e2349930. doi:10.1001/jamanetworkopen.2023.49930
EQUITY, DIVERSITY, AND INCLUSION
Zoe King, MS; Qiang Zhang, BA; Jane W. Liang, PhD; et al.
This qualitative study examines perceptions of barriers and facilitators to family building among physicians and medical students of different gender identities and sexual orientations.
JAMA Netw Open. 2023;6(12):e2349937. doi:10.1001/jamanetworkopen.2023.49937
PEDIATRICS
Sayaka Fukuda, MD, PhD; Shiro Tanaka, PhD; Chihiro Kawakami, PhD; et al.
This cohort study investigates the associations of exposure to maternal serum folic acid levels and maternal folic acid supplementation with the onset of Kawasaki disease (KD) during infancy among offspring.
JAMA Netw Open. 2023;6(12):e2349942. doi:10.1001/jamanetworkopen.2023.49942
ONCOLOGY
Yasoda Satpathy, BS; Percival Nam, BS; Matthew Moldovan, BS; et al.
This cohort study examined changes in the capture rate of the National Cancer Database of Hispanic individuals and American Indian or Alaska Native individuals diagnosed with breast, colorectal, lung, and prostate cancer.
JAMA Netw Open. 2023;6(12):e2350237. doi:10.1001/jamanetworkopen.2023.50237