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October 2024 - January 1908

Decade

Year

Issue

May 2020, Vol 180, No. 5, Pages 628-804

Viewpoint

Health Care Policy and Law

Integrated Drug Reviews at the US Food and Drug Administration鈥擫egal Concerns and Knowledge Lost

Matthew Herder, JSM, LLM; Christopher J. Morten, PhD, JD; Peter Doshi, PhD
Abstract Full Text
JAMA Intern Med. 2020;180(5):629-630. doi:10.1001/jamainternmed.2020.0074

This Viewpoint argues against the US Food and Drug Administration鈥檚 replacement of individual scientific reviews with integrated reviews for new drug approvals.

Health Care Policy and Law

The Skyrocketing Cost of Rectal Indomethacin

B. Joseph Elmunzer, MD, MSc; Inmaculada Hernandez, PharmD, PhD; Walid F. Gellad, MD, MPH
Abstract Full Text
JAMA Intern Med. 2020;180(5):631-632. doi:10.1001/jamainternmed.2020.0099

This Viewpoint discusses the rising cost of rectal indomethacin medication, a drug used for preventing pancreatitis following endoscopic retrograde cholangiopancreatography.

Investing in the Health of American Indians and Alaska Natives

Michael A. Incze, MD, MSEd; Matthew L. Tobey, MD, MPH; Thomas D. Sequist, MD, MPH
Abstract Full Text
JAMA Intern Med. 2020;180(5):633-634. doi:10.1001/jamainternmed.2020.0189

This Viewpoint discusses the importance of investing in the health of American Indians and Alaskan Natives.

Lessons Learned from the Australian Bushfires: Climate Change, Air Pollution, and Public Health

Sotiris Vardoulakis, PhD; Guy Marks, PhD; Michael J. Abramson, PhD
Abstract Full Text
JAMA Intern Med. 2020;180(5):635-636. doi:10.1001/jamainternmed.2020.0703

This Viewpoint discusses the many public health hazards associated with air pollution caused by climate change鈥搑elated bushfire and wildfire events.

Original Investigation

Less Is More

Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension

Rachel D. Savage, PhD; Jessica D. Visentin, PharmD; Susan E. Bronskill, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):643-651. doi:10.1001/jamainternmed.2019.7087

This population-based cohort study evaluates the association between being newly dispensed a calcium channel blocker and subsequent dispensing of a loop diuretic in older adults with hypertension.

Physician Work Environment and Well-Being

Assessment of the Prevalence of Medical Student Mistreatment by Sex, Race/Ethnicity, and Sexual Orientation

Katherine A. Hill, BA, BS; Elizabeth A. Samuels, MD, MPH, MHS; Cary P. Gross, MD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):653-665. doi:10.1001/jamainternmed.2020.0030

This cohort study examines the association between reported mistreatment and medical student sex, race/ethnicity, and sexual orientation.

Comparison of the Effectiveness of Single-Component and Multicomponent Interventions for Reducing Radiation Doses in Patients Undergoing Computed Tomography: A Randomized Clinical Trial

Rebecca Smith-Bindman, MD; Philip Chu, MS; Yifei Wang, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):666-675. doi:10.1001/jamainternmed.2020.0064

This randomized clinical trial assesses the effectiveness of 2 interventions to reduce radiation doses in patients undergoing computed tomography (CT).

Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults

Pallavi P. Balte, MBBS, PhD; Paulo H.M. Chaves, MD, PhD; David J. Couper, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):676-686. doi:10.1001/jamainternmed.2020.0104

This cohort study assesses the association of chronic bronchitis with adverse respiratory health outcomes in adult ever smokers and never smokers.

Lobbying Expenditures and Campaign Contributions by the Pharmaceutical and Health Product Industry in the United States, 1999-2018

Olivier J. Wouters, PhD
Abstract Full Text
open access
JAMA Intern Med. 2020;180(5):688-697. doi:10.1001/jamainternmed.2020.0146

This observational study uses publicly available data to analyze how much the pharmaceutical and health product industry spent on campaign contributions and lobbying in the US from 1999 to 2018.

Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death

Timothy F. Simpson, MD, PharmD; James W. Salazar, MD, MAS; Eric Vittinghoff, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):698-706. doi:10.1001/jamainternmed.2020.0148

This case-control study evaluates the association between QT-prolonging medications and autopsy-defined sudden arrhythmic death vs nonarrhythmic sudden death in an autopsy cohort.

Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis

Jonathan D. Baghdadi, MD, PhD; Robert H. Brook, MD, ScD; Daniel Z. Uslan, MD, MBA; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):707-716. doi:10.1001/jamainternmed.2020.0183

This cohort study examines the association of a care bundle for early sepsis management with mortality and organ dysfunction in adult hospitalized patients with community-onset or hospital-onset sepsis.

Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate

Yao Qiao, MPH; Jung-Im Shin, MD, PhD; Teresa K. Chen, MD, MHS; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):718-726. doi:10.1001/jamainternmed.2020.0193

This cohort study investigates the association of renin-angiotensin system blockade therapy discontinuation after estimated glomerular filtration rate decreases with the risk of mortality, major adverse cardiovascular events, and end-stage kidney disease.

Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial

Raymond F. Anton, MD; Patricia Latham, PhD; Konstantin Voronin, MD, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):728-736. doi:10.1001/jamainternmed.2020.0249

This randomized clinical trial examines the efficacy of gabapentin as pharmacotherapy for alchohol use disorder in adults with a history of alcohol withdrawal.

Multicenter Emergency Department Validation of the Canadian Syncope Risk Score

Venkatesh Thiruganasambandamoorthy, MBBS, MSc; Marco L. A. Sivilotti, MD, MSc; Natalie Le Sage, MD, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):737-744. doi:10.1001/jamainternmed.2020.0288

This cohort study evaluates the Canadian Syncope Risk Score to validate its ability to predict 30-day serious outcomes during emergency department evaluation.

Development and Validation of a Penicillin Allergy Clinical Decision Rule

Jason A. Trubiano, MBBS, PhD; Sara Vogrin, MBBS, MBiostat; Kyra Y. L. Chua, MBBS, PhD; et al.
Abstract Full Text
free access has audio
JAMA Intern Med. 2020;180(5):745-752. doi:10.1001/jamainternmed.2020.0403

This diagnostic study develops and validates a penicillin allergy clinical decision rule that enables point-of-care risk assessment of patient-reported penicillin allergies.

  • Podcast: A Clinical Pharmacologist's Perspective on Penicillin Allergy

Association Between Medicaid Expansion and Rates of Opioid-Related Hospital Use

Hefei Wen, PhD; Aparna Soni, PhD; Alex Hollingsworth, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):753-759. doi:10.1001/jamainternmed.2020.0473

This observational differences-in differences study examines the rates of opioid-related emergency department visits and inpatient hospitalizations before and after state Medicaid expansions.

Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases

Solja T. Nyberg, PhD; Archana Singh-Manoux, PhD; Jaana Pentti, MSc; et al.
Abstract Full Text
open access
JAMA Intern Med. 2020;180(5):760-768. doi:10.1001/jamainternmed.2020.0618

This cohort study examines disease-free life-years in participants with varying combinations of lifestyle risk factors.

Editorial

Updated Hepatitis C Virus Screening Recommendation鈥擜 Step Forward

Jennifer C. Price, MD, PhD; Danielle Brandman, MD, MAS
Abstract Full Text
has audio
JAMA Intern Med. 2020;180(5):637-639. doi:10.1001/jamainternmed.2019.7334
  • Podcast: USPSTF Recommendation: Screening for Hepatitis C Virus Infection in Adolescents and Adults

JAMA Internal Medicine鈥擳he Year in Review, 2019

Rita F. Redberg, MD, MSc
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):639-640. doi:10.1001/jamainternmed.2019.7523

Lobbying Expenditures, Campaign Contributions, and Health Care鈥擣ollow the Money

Robert Steinbrook, MD
Abstract Full Text
JAMA Intern Med. 2020;180(5):640-642. doi:10.1001/jamainternmed.2020.0145
Invited Commentary

Antihypertensive Prescribing Cascades as High-Priority Targets for Deprescribing

Timothy S. Anderson, MD, MAS; Michael A. Steinman, MD
Abstract Full Text
JAMA Intern Med. 2020;180(5):651-652. doi:10.1001/jamainternmed.2019.7082

Long-term Sequelae of Nonobstructive Chronic Bronchitis鈥擨s Airflow Obstruction Important?

Prescott G. Woodruff, MD, MPH; Stephen C. Lazarus, MD
Abstract Full Text
JAMA Intern Med. 2020;180(5):686-687. doi:10.1001/jamainternmed.2019.7280

How Effective Is the Early Management Bundle for Severe Sepsis/Septic Shock?

Hannah Moreira, MD, MPH; Richard Sinert, DO
Abstract Full Text
JAMA Intern Med. 2020;180(5):716-717. doi:10.1001/jamainternmed.2020.0180

Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Replacement鈥擡ffective in Stroke Prevention?

Rohan Khera, MD, MSCS; Saket Girotra, MD, SM
Abstract Full Text
JAMA Intern Med. 2020;180(5):785-786. doi:10.1001/jamainternmed.2019.6763
Editor's Note

Physician Work Environment and Well-Being

Addressing Mistreatment in Medical Education

Anjali B. Thakkar, MD, MBA; Colette Dejong, MD, MS; Mitchell H. Katz, MD
Abstract Full Text
JAMA Intern Med. 2020;180(5):665. doi:10.1001/jamainternmed.2020.0004

Continuation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Face of Kidney Disease Progression鈥擲afe and Possibly Life Saving

Colette DeJong, MD, MS; Richard W. Grant, MD, MPH
Abstract Full Text
JAMA Intern Med. 2020;180(5):727. doi:10.1001/jamainternmed.2020.0300
Review

Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review

Brad Spellberg, MD; Henry F. Chambers, MD; Daniel M. Musher, MD; et al.
Abstract Full Text
has audio
JAMA Intern Med. 2020;180(5):769-777. doi:10.1001/jamainternmed.2020.0555

This narrative review documents the shift from intravenous-only antibiotics to oral step-down therapy for patients with infective endocarditis.

  • Podcast: Evaluation of the Shift From Intravenous Antibiotics to Oral Step-Down Therapy for Infective Endocarditis
Teachable Moment

Less Is More

Not All Hypertension Is a Lifelong Disease: A Teachable Moment

Shumin Yang, MD, PhD; Jinbo Hu, MD, PhD; Qifu Li, MD, PhD
Abstract Full Text
JAMA Intern Med. 2020;180(5):781-782. doi:10.1001/jamainternmed.2020.0361

This Teachable Moment encourages clinicians to be aware of the high prevalence of primary aldosteronism and to consider screening in appropriately selected patients.

Research Letter

Early Experience With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in the United States

Mohamad Alkhouli, MD; Fahad Alqahtani, MD; Alyssa Hartsell Harris, MPH; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):783-784. doi:10.1001/jamainternmed.2019.6767

This survey study evaluates the early post鈥揢S Food and Drug Administration approval experience with an embolic protection device used during transcatheter aortic valve replacement procedures.

Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life

Brian L. Block, MD; Sun Young Jeon, MS, PhD; Rebecca L. Sudore, MD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):786-789. doi:10.1001/jamainternmed.2019.7535

This study uses Medicare claims data to identify and assess disparities in the use of advance care planning among adults 65 years or older who died between 2000 and 2015 and received intensive care during the last 30 days of life.

Sex Differences in Salaries of Department Chairs at Public Medical Schools

Michael Mensah, MD, MPH; Whitney Beeler, MD; Lisa Rotenstein, MD, MBA; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):789-792. doi:10.1001/jamainternmed.2019.7540

This study investigates whether sex pay differences exist among clinical department chairs from 29 state medical schools in 12 states.

Five-Year Follow-up of a Randomized Clinical Trial Testing Mailed Nicotine Patches to Promote Tobacco Cessation

John A. Cunningham, PhD; Vladyslav Kushnir, PhD; Peter Selby, MBBS; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):792-793. doi:10.1001/jamainternmed.2020.0001

This study assesses the outcomes of nicotine patches mailed to smokers who were participants in a previous randomized clinical trial to promote tobacco cessation.

Estimation of Glomerular Filtration Rate With vs Without Including Patient Race

Andrew S. Levey, MD; Hocine Tighiouart, MS; Silvia M. Titan, MD, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):793-795. doi:10.1001/jamainternmed.2020.0045

This cross-sectional study evaluates the use of race in estimating glomerular filtration rate and whether height and weight could substitute for race using pooled data from 10 studies of people with and without chronic kidney disease.

Generalizability of Clinical Trials Supporting the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline

Timothy S. Anderson, MD, MAS; Michelle Odden, PhD; Joanne Penko, MS, MPH; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):795-797. doi:10.1001/jamainternmed.2020.0051

This study uses National Health and Nutrition Examination Survey data to evaluate whether patients enrolled in the clinical trials that support the American College of Cardiology/American Heart Association (ACC/AHA) guideline are representative of the US adult population recommended additional pharmacotherapy by the ACC/AHA guideline.

Comparison of Industry Payments in 2017 With Annual Salary in a Cohort of Academic Oncologists

Jennifer Gill, MS; Alyson Haslam, PhD; Tyler Crain, MS; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):797-799. doi:10.1001/jamainternmed.2020.0090

This study uses public employee salary data from 14 US public medical schools and the Open Payments database from the US Centers for Medicare & Medicaid Services to examine the ratio of academic oncologists鈥� reported salaries to their general payments from the medical industry.

Use and Costs of Breast Cancer Screening for Women in Their 40s in a US Population With Private Insurance

Natalia Kunst, MSc; Jessica B. Long, MPH; Xiao Xu, PhD; et al.
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):799-801. doi:10.1001/jamainternmed.2020.0262

This study uses Blue Cross Blue Shield Axis data to examine the total annual cost of breast cancer screening for women aged 40 through 49 years in the United States.

Comparison of Priority vs Standard US Food and Drug Administration Premarket Approval Review for High-Risk Medical Devices

Caroline Ong, MD, MHS; Vy K. Ly, MD; Rita F. Redberg, MD, MSc
Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):801-803. doi:10.1001/jamainternmed.2020.0297

This study compares US Food and Drug Administration premarket approval review times for priority vs standard review for high-risk devices.

Challenges in Clinical Electrocardiography

Alternating QRS Complex Morphology in a Man Presenting With Stroke

Jacob J. Mayfield, MD; Nora Goldschlager, MD
Abstract Full Text
JAMA Intern Med. 2020;180(5):778-780. doi:10.1001/jamainternmed.2020.0463

This case report describes a man in his 70s who presented with left-sided hemiparesis, dysarthria, gaze deviation in the right eye, and left-sided hemineglect.

Comment & Response

Concerns Remain Regarding Long-term Ozone Exposure and Respiratory Outcomes

Minjing Luo, MD; Ping Li, MD, PhD; Wenquan Niu, PhD
Abstract Full Text
JAMA Intern Med. 2020;180(5):803-804. doi:10.1001/jamainternmed.2020.0574

Concerns Remain Regarding Long-term Ozone Exposure and Respiratory Outcomes鈥擱eply

Laura M. Paulin, MD, MHS; Joel D. Kaufman, MD, MPH; Nadia N. Hansel, MD, MPH
Abstract Full Text
JAMA Intern Med. 2020;180(5):804. doi:10.1001/jamainternmed.2020.0577
Peer Reviewers List

JAMA Internal Medicine Peer Reviewers in 2019

Abstract Full Text
free access online only
JAMA Intern Med. 2020;180(5):e200154. doi:10.1001/jamainternmed.2020.0154
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2020;180(5):628. doi:10.1001/jamainternmed.2019.4367
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