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June 2016, Vol 176, No. 6, Pages 725-871

In This Issue of JAMA Internal Medicine

Highlights

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):725-727. doi:10.1001/jamainternmed.2015.4882
Viewpoint

How Patent Troll Legislation Can Increase Timely Access to Generic Drugs

Abstract Full Text
JAMA Intern Med. 2016;176(6):729-730. doi:10.1001/jamainternmed.2016.1867

The Viewpoint discusses the effects of 鈥減atent trolls鈥 on generic drug prices and availability.

Inside Story

Less Is More

To Cure Sometimes, to Relieve Often, to Comfort Always

Abstract Full Text
JAMA Intern Med. 2016;176(6):731-732. doi:10.1001/jamainternmed.2016.1220
Editorial

Promise and Peril for Generic Drugs

Abstract Full Text
JAMA Intern Med. 2016;176(6):733-734. doi:10.1001/jamainternmed.2016.1720
Original Investigation

Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):743-752. doi:10.1001/jamainternmed.2016.1189

This randomized clinical trial examines the effects of a 2-year calorie restriction program on mood, quality of life, sleep, and sexual function in normal-weight adults.

Innovative Self-Regulation Strategies to Reduce Weight Gain in Young Adults: The Study of Novel Approaches to Weight Gain Prevention (SNAP) Randomized Clinical Trial

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):755-762. doi:10.1001/jamainternmed.2016.1236

This randomized clinical trial compared 2 self-regulation interventions vs control in reducing weight gain in young adults over a mean follow-up of 3 years.

Association of Industry Payments to Physicians With the Prescribing of Brand-name Statins in Massachusetts

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):763-768. doi:10.1001/jamainternmed.2016.1709

This study uses Medicare Part D prescriptions claims data and Massachusetts physicians payment database data to evaluate associations between industry payments to physicians and prescribing of brand-name statins.

Less Is More

Estimation of Potential Savings Through Therapeutic Substitution

Abstract Full Text
free access has multimedia has audio
JAMA Intern Med. 2016;176(6):769-775. doi:10.1001/jamainternmed.2016.1704

This cross-sectional study estimates potential savings through therapeutic substitution in terms of both overall and out-of-pocket expenditures of branded drugs when a generic in the same class with the same indication was available.

Association of Religious Service Attendance With Mortality Among Women

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):777-785. doi:10.1001/jamainternmed.2016.1615

This prospective study uses data from the Nurses鈥 Health Study to evaluate associations between attendance at religious services and mortality in women.

Quality of Care for White and Hispanic Medicare Advantage Enrollees in the United States and Puerto Rico

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):787-794. doi:10.1001/jamainternmed.2016.0267

This population-based study using the Medicare Advantage database examines the differences in care between Hispanic enrollees in Puerto Rico and Hispanic and white enrollees in the United States.

Effect of Detecting and Isolating Clostridium difficile Carriers at Hospital Admission on the Incidence of C difficile Infections: A Quasi-Experimental Controlled Study

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):796-804. doi:10.1001/jamainternmed.2016.0177

This quasi-experimental controlled study investigates the effect of detecting and isolating Clostridium difficile asymptomatic carriers at hospital admission on the incidence of health care鈥揳ssociated C difficile infection in a Canadian acute care facility.

Association of Environmental Contamination in the Home With the Risk for Recurrent Community-Associated, Methicillin-Resistant Staphylococcus aureus Infection

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):807-815. doi:10.1001/jamainternmed.2016.1500

This cohort study assesses whether household environmental contamination increases the risk for recurrent infection among individuals with a community-associated methicillin-resistant Staphylococcus aureus infection.

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):816-825. doi:10.1001/jamainternmed.2016.1548

This study of pooled data from 12 US and European cohorts examines the association of leisure-time physical activity with incidence of 26 common types of cancer and whether the associations vary by body size and/or smoking.

Association Between Acute Neuropsychiatric Events and Helicobacter pylori Therapy Containing Clarithromycin

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):828-834. doi:10.1001/jamainternmed.2016.1586

This case series explores the safety considerations of clarithromycin by investigating the association between Helicobacter pylori therapy containing clarithromycin and acute neuropsychiatric events.

Invited Commentary

Obesity Management and Prevention: More Questions Than Answers

Abstract Full Text
JAMA Intern Med. 2016;176(6):753-754. doi:10.1001/jamainternmed.2016.1211

Empirical Studies About Attendance at Religious Services and Health

Abstract Full Text
JAMA Intern Med. 2016;176(6):785-786. doi:10.1001/jamainternmed.2016.1626

Disparities in Health Care in Puerto Rico Compared With the United States

Abstract Full Text
JAMA Intern Med. 2016;176(6):794-795. doi:10.1001/jamainternmed.2016.1144

Active Surveillance and Isolation of Asymptomatic Carriers of Clostridium difficile at Hospital Admission: Containing What Lies Under the Waterline

Abstract Full Text
JAMA Intern Med. 2016;176(6):805-806. doi:10.1001/jamainternmed.2016.1118

The Promise of Leisure-Time Physical Activity to Reduce Risk of Cancer Development

Abstract Full Text
JAMA Intern Med. 2016;176(6):826-827. doi:10.1001/jamainternmed.2016.1521

Medicaid Coverage and Access to Care for American Indians and Alaska Natives Under the Affordable Care Act

Abstract Full Text
JAMA Intern Med. 2016;176(6):860-861. doi:10.1001/jamainternmed.2016.1786
Editor's Note

Therapeutic Substitution鈥擲hould It Be Systematic or Automatic?

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):776. doi:10.1001/jamainternmed.2016.2271

Cleaning House鈥擡nvironmental Contamination in the Home

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):815. doi:10.1001/jamainternmed.2016.1493

Triage, Copayments, and Emergency Department Visits

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):854-855. doi:10.1001/jamainternmed.2016.0882
Special Communication

Standardized Best Practices and Individual Craft-Based Medicine: A Conversation About Quality

Abstract Full Text
has audio
JAMA Intern Med. 2016;176(6):835-838. doi:10.1001/jamainternmed.2016.1641

In this Special Communication, a director of a community hospital quality program and the chief quality officer of a health care system discuss the benefits and risks of standardization in health care and develop principles of responsible standardization are presented.

Teachable Moment

Less Is More

The Horrible Taste of Nectar and Honey鈥擨nappropriate Use of Thickened Liquids in Dementia: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2016;176(6):735-736. doi:10.1001/jamainternmed.2016.1384

This Teachable Moment questions the routine use of thickened liquids to prevent pneumonia in patients with dementia.

Less Is More

Complications of Indwelling Urinary Catheter Care and Care Transitions: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2016;176(6):737-738. doi:10.1001/jamainternmed.2016.0606

This case reported in this Teachable Moment emphasizes the importance of catheter care as the responsibility of physicians as well as nurses.

Less Is More

Cancer Screening After Unprovoked Venous Thromboembolism: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2016;176(6):739-740. doi:10.1001/jamainternmed.2016.1783

This Teachable Moment discusses how aggressive physicians should be in screening for an occult cancer in patients with unprovoked venous thromboembolism.

Less Is More

False Bed Alarms: A Teachable Moment

Abstract Full Text
JAMA Intern Med. 2016;176(6):741-742. doi:10.1001/jamainternmed.2016.1885

This Teachable Moment evaluates the use of bed alarms as a fall-prevention strategy.

Challenges in Clinical Electrocardiography

Deep T-Wave Inversions After Pacemaker Adjustment

Abstract Full Text
JAMA Intern Med. 2016;176(6):839-840. doi:10.1001/jamainternmed.2016.1121

PR Interval Prolongation in a Patient With Infective Endocarditis: Subtle Changes of Serious Complications

Abstract Full Text
has multimedia
JAMA Intern Med. 2016;176(6):841-843. doi:10.1001/jamainternmed.2016.1644
Research Letter

Prevalence and Predictors of Generic Drug Skepticism Among Physicians: Results of a National Survey

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):845-847. doi:10.1001/jamainternmed.2016.1688

This survey study investigates attitudes toward prescribing generic drugs among internists and specialists in endocrinology, hematology, and infectious diseases.

Less Is More

Generic Medication Prescription Rates After Health System鈥揥ide Redesign of Default Options Within the Electronic Health Record

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):847-848. doi:10.1001/jamainternmed.2016.1691

This study examines prescription data from the University of Pennsylvania Health System outpatient clinics to compare generic medication prescription rates before and after a redesign of the electronic health record display defaults.

Association Between the Centers for Medicare and Medicaid Services Hospital Star Rating and Patient Outcomes

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):848-850. doi:10.1001/jamainternmed.2016.0784

This study investigates whether hospitals with more stars (on the Centers for Medicare and Medicaid Services rating system) have lower risk-adjusted 30-day mortality and readmissions than hospitals with less stars.

Association of Insufficient Sleep With Respiratory Infection Among Adults in the United States

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):850-852. doi:10.1001/jamainternmed.2016.0787

This study examines associations between self-reported measures of sleep and the probability of occurrence of colds and infections in a nationally representative sample of adults.

Urgent Care Needs Among Nonurgent Visits to the Emergency Department

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):852-854. doi:10.1001/jamainternmed.2016.0878

This study uses data from the National Hospital Ambulatory Medical Care Survey to examine whether a triage determination of nonurgent status in the emergency department ruled out the possibility of serious pathologic conditions, as compared with visits deemed as urgent.

Upcoding and Anesthesia Risk in Outpatient Gastrointestinal Endoscopy Procedures

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):855-856. doi:10.1001/jamainternmed.2016.1244

This study discusses the marked increase in the coding of risk from anesthesia for outpatient gastrointestinal procedures from 2005 to 2013.

The Adequacy of Individual Hospital Data to Identify High Utilizers and Assess Community Health

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):856-858. doi:10.1001/jamainternmed.2016.1248

This study examined the patterns of hospital use of all patients with more than 5 emergency department visits to Maryland hospitals in 2014 to determine whether high utilizers can be identified by data from individual hospitals.

Health Care Reform

Health Reform and Coverage Changes Among Native Americans

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):858-860. doi:10.1001/jamainternmed.2016.1695

This study evaluates changes in insurance and Indian Health Service coverage among Native Americans following the Affordable Care Act鈥檚 implementation.

Comment & Response

In Defense of Off-label Prescribing

Abstract Full Text
JAMA Intern Med. 2016;176(6):861. doi:10.1001/jamainternmed.2016.1403

In Defense of Off-label Prescribing鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):861-862. doi:10.1001/jamainternmed.2016.1406

Hypertension, the Swedish Patient Register, and Selection Bias

Abstract Full Text
JAMA Intern Med. 2016;176(6):862-863. doi:10.1001/jamainternmed.2016.1556

Questioning Nicotine Replacement Therapy Without Behavioral Support

Abstract Full Text
JAMA Intern Med. 2016;176(6):863-864. doi:10.1001/jamainternmed.2016.1559

Hypertension, the Swedish Patient Register, and Selection Bias鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):863. doi:10.1001/jamainternmed.2016.1562

Questioning Nicotine Replacement Therapy Without Behavioral Support鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):864-865. doi:10.1001/jamainternmed.2016.1565

Less Is More

Estimating Vitamin D Status and the Choice of Supplementation Dose

Abstract Full Text
JAMA Intern Med. 2016;176(6):865. doi:10.1001/jamainternmed.2016.1612

Estimating Vitamin D Status and the Choice of Supplementation Dose鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):865-866. doi:10.1001/jamainternmed.2016.1629

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):866. doi:10.1001/jamainternmed.2016.1845

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):866-867. doi:10.1001/jamainternmed.2016.1848

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):867. doi:10.1001/jamainternmed.2016.1851

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):867-868. doi:10.1001/jamainternmed.2016.1854

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):868. doi:10.1001/jamainternmed.2016.1857

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease

Abstract Full Text
JAMA Intern Med. 2016;176(6):868-869. doi:10.1001/jamainternmed.2016.1860

Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):869-870. doi:10.1001/jamainternmed.2016.1863

Imaging More Wisely鈥擜lready At Work

Abstract Full Text
JAMA Intern Med. 2016;176(6):870. doi:10.1001/jamainternmed.2016.2072
  • Editorial
    Imaging More Wisely
    JAMA Intern Med

Imaging More Wisely鈥擜lready At Work鈥擱eply

Abstract Full Text
JAMA Intern Med. 2016;176(6):870-871. doi:10.1001/jamainternmed.2016.2075
  • Editorial
    Imaging More Wisely
    JAMA Intern Med
Correction

Updated Supplement

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):871. doi:10.1001/jamainternmed.2016.1684

Errors Throughout the Text

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):871. doi:10.1001/jamainternmed.2016.2244
Images From Our Readers

Manhattan Approach, Ed Koch Queensborough Bridge

Abstract Full Text
JAMA Intern Med. 2016;176(6):738. doi:10.1001/jamainternmed.2016.2083
JAMA Internal Medicine Masthead

JAMA Internal Medicine

Abstract Full Text
free access
JAMA Intern Med. 2016;176(6):728. doi:10.1001/jamainternmed.2015.4883
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