In Reply We thank Lisi for contributing a Letter to the Editor regarding our recent Patient Page about edible cannabis.1 Lisi emphasized the potential harms of edible cannabis products, including their unpredictable effects, the risk for accidental exposure and intoxication leading to emergency department visits, and the lack of strong unifying regulatory and oversight frameworks for medical cannabis at the national level. We completely agree, specifically highlighting each of these potential harms in the Patient Page along with other established risks such as impaired driving, cognitive effects, and interactions with commonly prescribed medications. Emphasizing these risks is a crucial part of patient counseling, and we thank Lisi for providing additional information to guide this practice.