Buprenorphine is a highly effective first-line medication to treat opioid use disorder (OUD). Buprenorphine treats opioid craving and withdrawal, is associated with reduced opioid use and risk of HIV and hepatitis C, lowers all-cause mortality and opioid overdose risk by 60%, and increases treatment retention.1 The number needed to treat for buprenorphine to prevent 1 fatal opioid overdose is 52.6; for comparison, the number needed to treat for aspirin to prevent 1 nonfatal myocardial infarction is 333.2