In this issue of JAMA Internal Medicine, Woodruff et al1 present a cross-sectional study of patients 50 years and older who were hospitalized and tested positive for respiratory syncytial virus (RSV), reporting that 22% experienced an acute cardiac event, including acute exacerbation of heart failure or myocardial injury. The already high in-hospital mortality rate of 5% for older adults with RSV-associated hospitalizations was doubled among those experiencing a concurrent acute cardiac event.