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December 2021, Vol 157, No. 12, Pages 1401-1524

Editorial

Melanoma Screening鈥擳ime for a Reset?

Allan C. Halpern, MD; Michael A. Marchetti, MD
Abstract Full Text
JAMA Dermatol. 2021;157(12):1409-1411. doi:10.1001/jamadermatol.2021.3883

Novel Treatments for Chronic Erythema Multiforme Inform Translational Science and Disease Pathogenesis

Arturo R. Dominguez, MD; Samantha N. Lopez, BS
Abstract Full Text
JAMA Dermatol. 2021;157(12):1411-1413. doi:10.1001/jamadermatol.2021.4082
Original Investigation

Machine Learning鈥揃ased Deep Phenotyping of Atopic Dermatitis: Severity-Associated Factors in Adolescent and Adult Patients

Laura Maintz, MD; Thomas Welchowski, PhD; Nadine Herrmann, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1414-1424. doi:10.1001/jamadermatol.2021.3668

This cross-sectional study performs deep phenotyping and identification of severity-associated factors in adolescent and adult patients with atopic dermatitis.

Association Between Melanoma Detected During Routine Skin Checks and Mortality

Caroline G. Watts, PhD; Kirstie McLoughlin, DPhil; Chris Goumas, MPH; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1425-1436. doi:10.1001/jamadermatol.2021.3884

This cohort study investigates the association between melanomas diagnosed during routine skin checks and melanoma-specific and all-cause mortality.

Association of Sun-Protective Behaviors With Bone Mineral Density and Osteoporotic Bone Fractures in US Adults

Mohsen Afarideh, MD, MPH; Julio C. Sartori-Valinotti, MD; Megha M. Tollefson, MD
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1437-1446. doi:10.1001/jamadermatol.2021.4143

This cross-sectional study uses data from the National Health and Nutrition Examination Survey to investigate the association of sun-protective behaviors with bone mineral density and the prevalence of osteoporotic fractures among US adults.

Risks of Multiple Skin Cancers in Organ Transplant Recipients: A Cohort Study in 2 Administrative Data Sets

Mackenzie R. Wehner, MD, MPhil; Jiangong Niu, PhD; Lee Wheless, MD, PhD; et al.
Abstract Full Text
free access has active quiz has audio
JAMA Dermatol. 2021;157(12):1447-1455. doi:10.1001/jamadermatol.2021.4148

This cohort study determines the risks over time and risk factors for organ transplant recipients developing any skin cancer posttransplant, a subsequent skin cancer after the first posttransplant skin cancer, and 10 or more skin cancers.

  • Podcast: Risks of Multiple Skin Cancers in Organ Transplant Recipients

Importance of Supplemental Patch Testing Beyond a Screening Series for Patients With Dermatitis: The North American Contact Dermatitis Group Experience

Erin M. Warshaw, MD, MS; Michele Buonomo, BA; Joel G. DeKoven, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1456-1465. doi:10.1001/jamadermatol.2021.4314

This cross-sectional study examines the use of supplemental allergen or substance testing in addition to the standard 65- to 70-item testing to identify contact allergens undetected in patients with contact dermatitis.

Brief Report

Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation With Neutrophilic Dermatosis: A Family With a Novel Autosomal Recessive Mode of Inheritance

Hassan Vahidnezhad, PhD; Leila Youssefian, PhD; Amir Hossein Saeidian, MSc; et al.
Abstract Full Text
JAMA Dermatol. 2021;157(12):1466-1471. doi:10.1001/jamadermatol.2021.3899

This case series study examines the DNA of siblings and parents from a consanguineous family to find the genetic basis for pyrin-associated autoinflammation with neutrophilic dermatosis and to prescribe genotype-guided treatment.

Evaluation of Thalidomide Treatment of Patients With Chronic Erythema Multiforme: A Multicenter Retrospective Cohort Study

Camille Roux, MD; Emilie Sbidian, MD, PhD; Jean-David Bouaziz, MD, PhD; et al.
Abstract Full Text
JAMA Dermatol. 2021;157(12):1472-1476. doi:10.1001/jamadermatol.2021.4083

This cohort study examines use of thalidomide as continuous treatment for patients with chronic erythema multiforme in French hospital dermatology departments.

Treatment of Persistent Erythema Multiforme With Janus Kinase Inhibition and the Role of Interferon Gamma and Interleukin 15 in Its Pathogenesis

Michael J. Murphy, BS; Diana Gruenstein, BA; Alice Wang, BS; et al.
Abstract Full Text
JAMA Dermatol. 2021;157(12):1477-1482. doi:10.1001/jamadermatol.2021.4084

This case series reports on the efficacy of Janus kinase inhibition in treating persistent erythema multiforme and elucidates its cytokine drivers.

Review

Bullous Dermatoses and Depression: A Systematic Review

Sarah P. Pourali, BS; Yasmin Gutierrez, BS; Alison H. Kucharik, BS; et al.
Abstract Full Text
JAMA Dermatol. 2021;157(12):1487-1495. doi:10.1001/jamadermatol.2021.4055

This systematic review synthesizes and interprets the current evidence on the association between bullous skin disease and depression.

Images in Dermatology

Perianal Chancres of Primary Syphilis

Herbert Castillo Valladares, MD; Errol Craig, MD; Kenneth A. Katz, MD, MSc, MSCE
Abstract Full Text
JAMA Dermatol. 2021;157(12):1496. doi:10.1001/jamadermatol.2021.3763

This case report describes multiple small, punched-out ulcers within an erythematous and hypopigmented plaque in the perianal area.

Gustatory Hyperhidrosis

Marlous L. Grijsen, PhD; Esther J. van Zuuren, MD
Abstract Full Text
JAMA Dermatol. 2021;157(12):1497. doi:10.1001/jamadermatol.2021.3303

This case report describes facial sweating, flushing, and discomfort minutes after exposure to vinegar.

JAMA Dermatology Clinicopathological Challenge

Violaceous Plaques on the Left Lower Extremity

Bianca Uzoma, BS; Paige Hoyer, MD; Kathleen Kroger, MD
Abstract Full Text
JAMA Dermatol. 2021;157(12):1498-1499. doi:10.1001/jamadermatol.2021.4295

A young man presented with large, purple plaques on the left lower extremity that had been enlarging and darkening for the past 5 years, with no associated pruritis, bleeding, or pain. What is your diagnosis?

Multiple Painless Subcutaneous Nodules on the Cheek of an Immunocompetent Man

Soufila Kudukkil Thazhathuveettil, MD; Hitaishi Mehta, MD, DNB; Keshavamurthy Vinay, MD, DNB
Abstract Full Text
JAMA Dermatol. 2021;157(12):1500-1501. doi:10.1001/jamadermatol.2021.4579

A man in his 30s employed as a painter presented with multiple painless nodules on his right cheek and episodic breathlessness, cough, and wheezing with expectoration of brownish sputum. What is your diagnosis?

JAMA Dermatology Patient Page

Stasis Dermatitis

Ritesh Agnihothri, MD; Kanade Shinkai, MD, PhD
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1524. doi:10.1001/jamadermatol.2021.3475

This Patient Page describes the symptoms, possible causes, and treatment of stasis dermatitis.

Research Letter

Characteristics and Outcomes of Eosinophilic Fasciitis鈥揂ssociated Monoclonal Gammopathy

Daniel R. Mazori, MD; Bina Kassamali, BA; Michelle S. Min, MD, MS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1508-1509. doi:10.1001/jamadermatol.2021.4302

This cross-sectional study analyzes the characteristics and outcomes of eosinophilic fasciitis鈥揳ssociated monoclonal gammopathy.

Content Analysis of Patient-Reported Outcome Measures Used in Patients With Nail Conditions: A Systematic Review

Khizar Abid, BHSc; Leah Algu, BHSc; Rakhshan Kamran, BSc; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1509-1511. doi:10.1001/jamadermatol.2021.4539

This systematic review identifies and examines the content of nail-specific patient questionnaires to understand if some instruments may be better suited to measuring different research outcomes.

Lesbian, Gay, Bisexual, and Transgender Identity and Disclosure Among Dermatologists in the US

Matthew D. Mansh, MD; Erica Dommasch, MD, MPH; J. Klint Peebles, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1512-1514. doi:10.1001/jamadermatol.2021.4544

This survey study used data from a 2020 American Academy of Dermatology member satisfaction survey to assess lesbian, gay, bisexual, and transgender identity and disclosure among US dermatologists.

Observation

Reduction of Disease Burden With Early Sirolimus Treatment in a Child With Proteus Syndrome

Lisa Weibel, MD; Martin Theiler, MD; Ralph Gnannt, MD; et al.
Abstract Full Text
JAMA Dermatol. 2021;157(12):1514-1516. doi:10.1001/jamadermatol.2021.4305

This case report describes early, long-term sirolimus treatment for a teenage girl with Proteus syndrome.

Comment & Response

Incorporating Structural Competency Into Dermatologic Curricula

Erica Ogwumike, BA; Donald A. Glass II, MD, PhD; Rebecca Vasquez, MD
Abstract Full Text
JAMA Dermatol. 2021;157(12):1516-1517. doi:10.1001/jamadermatol.2021.4560

Incorporating Structural Competency Into Dermatologic Curricula鈥擱eply

Jenna C. Lester, MD; Susan C. Taylor, MD
Abstract Full Text
JAMA Dermatol. 2021;157(12):1517. doi:10.1001/jamadermatol.2021.1899
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2021;157(12):1401. doi:10.1001/jamadermatol.2020.3920
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