May 1, 2019 Issue of JAMA Dermatology

May 2019, Vol 155, No. 5, Pages 519-638

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text

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JAMA Dermatol. 2019;155(5):519. doi:10.1001/jamadermatol.2018.3513

Viewpoint

Hair Reduction for Transgender Persons: What Dermatologists Should Know and How They Can Help

Dustin H. Marks, BS; J. Klint Peebles, MD; Erica Dommasch, MD, MPH

Abstract Full Text

JAMA Dermatol. 2019;155(5):525-526. doi:10.1001/jamadermatol.2019.0149

This Viewpoint encourages more options and insurance coverage for transgender persons seeking hair reduction and steps dermatologists can take to improve access to services.

Editorial

JAMA Dermatology鈥擳he Year in Review, 2018

Kanade Shinkai, MD, PhD

Abstract Full Text

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JAMA Dermatol. 2019;155(5):527-528. doi:10.1001/jamadermatol.2019.0161

Psoralen Plus UV-A Therapy in the 21st Century: Use It or Lose It

Joan Guitart, MD

Abstract Full Text

JAMA Dermatol. 2019;155(5):529-530. doi:10.1001/jamadermatol.2018.5844

Molecular Corroboration of Type 2 Segmental Mosaicism in Various Types of Porokeratosis

Rudolf Happle, MD

Abstract Full Text

JAMA Dermatol. 2019;155(5):531-532. doi:10.1001/jamadermatol.2019.0134

Original Investigation

Evaluation of Low-Dose, Low-Frequency Oral Psoralen鈥揢V-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides: A Randomized Clinical Trial

Pablo Vieyra-Garcia, PhD; Regina Fink-Puches, MD; Stefanie Porkert, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):538-547. doi:10.1001/jamadermatol.2018.5905

This randomized clinical trial examines whether the use of psoralen鈥揢V-A with maintenance therapy can prolong clinical response and disease remission in patients with early-stage mycosis fungoides.

Second-Hit, Postzygotic PMVK and MVD Mutations in Linear Porokeratosis

Lihi Atzmony, MD; Habib M. Khan, MD; Young H. Lim, BA; et al.

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JAMA Dermatol. 2019;155(5):548-555. doi:10.1001/jamadermatol.2019.0016

This study of 3 individuals with linear porokeratosis examines whether the disease is associated with germline and somatic mutations in the PMVK and MVD genes using whole-exome sequencing.

Assessment of Sleep Disturbances and Exhaustion in Mothers of Children With Atopic Dermatitis

Faustine D. Ramirez, BA; Shelley Chen, BS; Sinéad M. Langan, FRCP, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):556-563. doi:10.1001/jamadermatol.2018.5641

This longitudinal cohort study analyzes data collected across 11 years to assess the association between the presence and severity of atopic dermatitis in children and maternal sleep disturbance among a population-based UK cohort of mother-child pairs.

Podcast: Assessment of Sleep and Exhaustion in Mothers of Children With Atopic Dermatitis

Topographic Phenotypes of Alopecia Areata and Development of a Prognostic Prediction Model and Grading System: A Cluster Analysis

Solam Lee, MD; Beom Jun Kim, MD; Chung-Hyeok Lee, MD; et al.

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JAMA Dermatol. 2019;155(5):564-571. doi:10.1001/jamadermatol.2018.5894

This cohort study uses cluster analysis to identify the topographic phenotypes of alopecia areata and establish a prediction model and grading system for stratifying prognoses.

Early Melanoma Nodal Positivity and Biopsy Rates Before and After Implementation of the 7th Edition of the AJCC Cancer Staging Manual

Chelsea Isom, MD, MPH; Lee Wheless, MD, PhD; Mary A. Hooks, MD, MBA; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):572-577. doi:10.1001/jamadermatol.2018.5902

This cohort study uses the National Cancer Database to analyze the sentinel lymph node biopsy rate and positivity rate for adults with T1 melanoma before and after implementation of the 7th edition of the AJCC Cancer Staging Manual.

Clinical and Histopathologic Characteristics of Melanocytic Lesions on the Volar Skin Without Typical Dermoscopic Patterns

Yasutomo Mikoshiba, MD; Akane Minagawa, MD, PhD; Hiroshi Koga, MD, PhD; et al.

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JAMA Dermatol. 2019;155(5):578-584. doi:10.1001/jamadermatol.2018.5926

This cohort study examines the frequency and clinical and dermoscopic characteristics of melanocytic lesions on the volar skin not displaying a parallel furrow pattern, lattice-like pattern, fibrillar pattern, or parallel ridge pattern on results of dermoscopy.

Application of Topical Phosphodiesterase 4 Inhibitors in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-analysis

Huan Yang, MD; Ji Wang, MD; Xin Zhang, MD, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):585-593. doi:10.1001/jamadermatol.2019.0008

This meta-analysis evaluated the efficacy and safety of topical phosphodiesterase 4 inhibitors in mild to moderate atopic dermatitis.

Brief Report

Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants

Donal J. Sexton, MD, PhD; Patrick O鈥橩elly, MSc; Eamonn O鈥橪eary, MSc; et al.

Abstract Full Text

JAMA Dermatol. 2019;155(5):594-598. doi:10.1001/jamadermatol.2018.4660

This study uses Irish national registry data to characterize variation in nonmelanoma skin cancer incidence by treatment modality among patients receiving multiple kidney transplants.

Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease

Gabriel E. Molina, BA; Saami Khalifian, MD; Jamie L. Mull, MD; et al.

Abstract Full Text

JAMA Dermatol. 2019;155(5):599-603. doi:10.1001/jamadermatol.2018.4793

This case series evaluates the topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory extramammary Paget disease.

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma

Kim Wong, MSc; Carla Daniela Robles-Espinoza, PhD; David Rodriguez, PhD; et al.

Abstract Full Text

JAMA Dermatol. 2019;155(5):604-609. doi:10.1001/jamadermatol.2018.3662

This study of 3 families, 1 from a clinical setting and 2 obtained from the GenoMEL Consortium, evaluated the association of the POT1 germline missense variant p.I78T with familial melanoma.

Images in Dermatology

Scrofuloderma

Sarah Oberhelman, BS; Jacqueline Watchmaker, MD; Tania Phillips, MD

Abstract Full Text

JAMA Dermatol. 2019;155(5):610. doi:10.1001/jamadermatol.2018.5651

This case report describes scrofuloderma in a 24-year-old woman.

Occupational Vision Loss Following Alexandrite Laser Exposure

Dimitrios Karagiannis, MD, PhD; Maria Stoupaki, MD; George A. Kontadakis, MD, MSc, PhD

Abstract Full Text

JAMA Dermatol. 2019;155(5):611. doi:10.1001/jamadermatol.2018.5524

This case report describes vision loss following unprotected exposure to an alexandrite laser.

JAMA Dermatology Clinicopathological Challenge

An Elderly Woman With Violaceous Swelling With Telangiectasia and Necrosis on the Face

Qian-Nan Jia, MS; Hong-Zhong Jin, MD; Yue-Ping Zeng, MD

Abstract Full Text

JAMA Dermatol. 2019;155(5):615-616. doi:10.1001/jamadermatol.2018.5316

A woman in her 60s presents with a 3-month history of pain, swelling, and erythema on her face, plus a history of breast cancer with lymph node metastasis. What is your diagnosis?

Vesicles and Bullae on the Right Cheek, Neck, and Both Hands

Guannan Zhu, MD, PhD; Wenjun Liao, MD, PhD

Abstract Full Text

JAMA Dermatol. 2019;155(5):617-618. doi:10.1001/jamadermatol.2018.5471

A man presents with bullae and vesicles on his face, neck, and hands with irregular hyperplasia and spongiosis of the epidermis, among other histological abnormalities. What is your diagnosis?

Violaceous Nodules in an Annular Configuration Encircling an Orthotopic Liver Transplant Scar

Michelle W. Cheng, MD; Young Mike Choi, MD; David S. Cassarino, MD, PhD

Abstract Full Text

JAMA Dermatol. 2019;155(5):619-620. doi:10.1001/jamadermatol.2018.5615

A man in his 50s presented with an abdominal skin eruption of 2 days鈥� duration; his medical history included hepatitis C, cirrhosis, and an orthotopic liver transplant 3 years prior. What is your diagnosis?

Research Letter

Association of Atherosclerosis Prevalence With Age, Race, and Traditional Risk Factors in Patients With Psoriasis

Kathryn A. Arnold, BS; Alison D. Treister, BS, BSHS; Peter A. Lio, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):622-623. doi:10.1001/jamadermatol.2018.5462

This analysis of aggregate data from electronic medical records assesses the prevalence of atherosclerosis in African American and white patients with psoriasis.

Association Between Hidradenitis Suppurativa and Lymphoma

Rachel Tannenbaum, BS; Andrew Strunk, MA; Amit Garg, MD

Abstract Full Text

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JAMA Dermatol. 2019;155(5):624-625. doi:10.1001/jamadermatol.2018.5230

This cohort analysis evaluates the risk of lymphoma in adult patients with hydradenitis suppurativa in the United States.

Multiple Cutaneous Squamous Cell Carcinoma in Immunosuppressed vs Immunocompetent Patients

Jessica L. Gonzalez, MD; Nithin D. Reddy, BS; Kiera Cunningham, BS; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):625-627. doi:10.1001/jamadermatol.2018.5595

This case-control study examines the association of multiple squamous cell carcinoma with poor outcomes in the immunosuppressed patient population.

Prevalence Estimates for Pemphigus in the United States: A Sex- and Age-Adjusted Population Analysis

Sara Wertenteil, BA; Amit Garg, MD; Andrew Strunk, MA; et al.

Abstract Full Text

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JAMA Dermatol. 2019;155(5):627-629. doi:10.1001/jamadermatol.2018.5954

This cross-sectional analysis using Explorys data examines the prevalence of pemphigus in US adults across age, sex, and race groups.

Observation

Occurrence of Extensive Cutaneous Human Papillomavirus Infection After Initiation of Tofacitinib Therapy

Florence Brunet-Possenti, MD; Charlotte Charpentier, MD, PhD; Yoram Bouhnik, MD, PhD; et al.

Abstract Full Text

JAMA Dermatol. 2019;155(5):629-631. doi:10.1001/jamadermatol.2018.5528

This case report describes a patient who developed extensive cutaneous human papillomavirus infection shortly after initiation of tofacitinib therapy.

Overlap of Bullous, Anti鈥揕aminin-332, and Anti-p200 Pemphigoid With Concomitant Anti鈥揅ontactin-1鈥揚ositive Inflammatory Polyneuropathy Treated With Intravenous Immunoglobulins as a Manifestation of Epitope Spreading

Alexander Wald, MD; Enno Schmidt, MD, PhD; Ferdinand Toberer, MD; et al.

Abstract Full Text

JAMA Dermatol. 2019;155(5):631-633. doi:10.1001/jamadermatol.2018.5536

This case report describes a patient who experienced bullous, anti鈥搇aminin-332, and anti-p200 pemphigoid with concomitant anti鈥揷ontactin-1鈥損ositive inflammatory polyneuropathy treated with intravenous immunoglobulins as a manifestation of epitope spreading.