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November 2019, Vol 155, No. 11, Pages 1213-1323

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1213. doi:10.1001/jamadermatol.2018.3543
Viewpoint

Less Toxic, More Effective Treatment鈥擜 Win-Win for Patients With Merkel Cell Carcinoma

Paul Nghiem, MD, PhD; Song Youn Park, MD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1223-1224. doi:10.1001/jamadermatol.2019.2584

This Viewpoint highlights 3 recent developments in the management of Merkel cell carcinoma.

Mohs Micrographic Surgery for Melanoma: As Use Increases, So Does the Need for Best Practices

Christopher J. Miller, MD; Cerrene N. Giordano, MD; H. William Higgins II, MD, MBE
Abstract Full Text
JAMA Dermatol. 2019;155(11):1225-1226. doi:10.1001/jamadermatol.2019.2589

This Viewpoint assesses the current practice of Mohs micrographic surgery compared with wide local excision for patients with special-site melanoma.

Editorial

Predicting Clinical Responses to Ustekinumab: Progress Toward a Future of Personalized Medicine

Andrew Blauvelt, MD, MBA
Abstract Full Text
JAMA Dermatol. 2019;155(11):1227-1228. doi:10.1001/jamadermatol.2019.2587

Improving Survival for Patients With Early-Stage Melanoma

Ian A. Maher, MD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1229-1230. doi:10.1001/jamadermatol.2019.2622
Original Investigation

Association of Serum Ustekinumab Levels With Clinical Response in Psoriasis

Teresa Tsakok, MA, MRCP; Nina Wilson, PhD; Nick Dand, PhD; et al.
Abstract Full Text
open access
JAMA Dermatol. 2019;155(11):1235-1243. doi:10.1001/jamadermatol.2019.1783

This cohort study evaluates clinical utility of monitoring serum levels of ustekinumab in patients with psoriasis.

Evolution of Excisional Surgery Practices for Melanoma in the United States

Michael P. Lee, BS; Joseph F. Sobanko, MD; Thuzar M. Shin, MD, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1244-1251. doi:10.1001/jamadermatol.2019.2346

This national cross-sectional analysis examines trends in the use of comprehensive margin assessment surgery among US adults with melanoma by tracking claims data for Mohs surgery.

Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma

Shayan Cheraghlou, BA; Sean R. Christensen, MD, PhD; George O. Agogo, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1252-1259. doi:10.1001/jamadermatol.2019.2890

This cohort study compares overall survival of patients undergoing Mohs micrographic surgery vs traditional wide margin excision for early-stage invasive melanoma in the National Cancer Database.

Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States

Jongwoo Kim, MD, MSc; Min Kyung Park, PhD; Wen-Qing Li, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1260-1268. doi:10.1001/jamadermatol.2019.1937

This cohort study examines whether vitamin A intake is associated with cutaneous squamous cell carcinoma risk among US adults.

Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis

David J. Margolis, MD, PhD; Nandita Mitra, PhD; Bradley Wubbenhorst, MS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1269-1276. doi:10.1001/jamadermatol.2019.1946

This registry cohort study describes and compares results of targeted sequencing of FLG loss-of-function variants in US children of African and European ancestry and the association of these variants with onset and persistence of atopic dermatitis.

Assessment of Deep Learning Using Nonimaging Information and Sequential Medical Records to Develop a Prediction Model for Nonmelanoma Skin Cancer

Hsiao-Han Wang, MD; Yu-Hsiang Wang; Chia-Wei Liang, MS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1277-1283. doi:10.1001/jamadermatol.2019.2335

This study uses machine learning to evaluate medical records from a database of 2 million randomly selected patients to develop a prediction model for incident nonmelanoma skin cancer from multidimensional nonimaging medical information.

Incidence of Long-term Opioid Use Among Opioid-Naive Patients With Hidradenitis Suppurativa in the United States

Sarah Reddy, BA; Lauren A.V. Orenstein, MD; Andrew Strunk, MA; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1284-1290. doi:10.1001/jamadermatol.2019.2610

This cohort study compares overall and subgroup incidence of long-term opioid use in a population of opioid-naive patients with hidradenitis suppurativa and controls from US electronic health record data.

Accuracy of Computer-Aided Diagnosis of Melanoma: A Meta-analysis

Vincent Dick, CandMed; Christoph Sinz, MD; Martina Mittlböck, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1291-1299. doi:10.1001/jamadermatol.2019.1375

This meta-analysis evaluates the accuracy of computerized systems in the diagnosis of melanoma in patients with skin lesions.

Images in Dermatology

Acquired Acrodermatitis Enteropathica

Ankur Guliani, MD; Anuradha Bishnoi, MD, DNB
Abstract Full Text
JAMA Dermatol. 2019;155(11):1305. doi:10.1001/jamadermatol.2019.2342

This case report describes a 6-month-old exclusively breastfed boy with red, oozy plaques over his face, genitals, and extremities who was diagnosed with acquired acrodermatitis enteropathica.

Infantile Systemic Hyalinosis

Li Liu, MM; Faliang Ren, MD; Qi Tan, MD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1306. doi:10.1001/jamadermatol.2019.2713

This case report describes a 19-month-old boy pearly papules in the perianal area and on the thighs, clawhand, contracture of the large joints, and gingival hyperplasia who was diagnosed with infantile systemic hyalinosis.

JAMA Dermatology Clinicopathological Challenge

Numerous Pink-Purple Papules in a Middle-aged Man

Michael R. Stephens, BA; Paul L. Haun, MD; Robert G. Micheletti, MD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1308-1309. doi:10.1001/jamadermatol.2019.2949

A man in his 50s with polyarticular inflammatory arthritis presented with numerous pink-purple papules on the trunk and extremities. What is your diagnosis?

Punctate Keratotic Papules on the Palm

Megan Brinkworth Vissing, MD; Leila Tolaymat, MD; Jason Sluzevich, MD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1310-1311. doi:10.1001/jamadermatol.2019.2956

A girl in her teens presented with punctate keratotic papules on the palm and third finger, which had been present since the age of 2 years. What is your diagnosis?

Research Letter

Development or Exacerbation of Head and Neck Dermatitis in Patients Treated for Atopic Dermatitis With Dupilumab

Angèle Soria, MD, PhD; Aurélie Du-Thanh, MD, PhD; Julien Seneschal, MD, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1312-1315. doi:10.1001/jamadermatol.2019.2613

This cohort study describes the development or exacerbation of head and neck dermatitis in patients treated with dupilumab for atopic dermatitis.

Assessment of Overpayment for Topical Dermatological Drugs鈥擟lawbacks

Kassidy Shumaker, MPH; Steve Maczuga, MS; Joslyn Kirby, MD, MS, MEd
Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1315-1317. doi:10.1001/jamadermatol.2019.3078

This cohort study investigates the prevalence and cost of overpayments for topical dermatologic prescription drugs.

Observation

Anetoderma Associated With a Succinate Dehydrogenase Gene Mutation: A Potential Link Between Anetoderma and Citric Acid Cycle Mutations

Adam K. Brys, MD; Larissa G. Rodriguez-Homs, MBS; Samantha Wennerberg, PA-C; et al.
Abstract Full Text
JAMA Dermatol. 2019;155(11):1317-1318. doi:10.1001/jamadermatol.2019.2579

This case report describes a patient with anetoderma associated with a succinate dehydrogenase gene mutation.

Refractory Generalized Granuloma Annulare Treated With Oral Apremilast

Anuradha Bishnoi, MD, DNB; Dinesh Raj, MD; Keshavamurthy Vinay, MD, DNB, MNAMS, MRCP (SCE); et al.
Abstract Full Text
JAMA Dermatol. 2019;155(11):1318-1320. doi:10.1001/jamadermatol.2019.2130

This case report describes 4 patients with treatment-resistant granuloma annulare subsequently treated with oral apremilast.

Orofacial Granulomatosis Presenting With Acquired Lymphangiectasia

Anthony D. Honigman, MBBS (Hons); Minhee Kim, MBBS (Hons); C.W. Chow, MD, FRCPA; et al.
Abstract Full Text
JAMA Dermatol. 2019;155(11):1320-1322. doi:10.1001/jamadermatol.2019.2689

This case report describes a patient with orofacial granulomatosis who developed acquired lymphangiectasia and was treated with immunosuppressive drugs and several rounds electrodesiccation treatment.

Comment & Response

Lymphatic and Hematogenous Dissemination in Patients With Primary Cutaneous Melanoma

Nikki R. Adler, PhD; Grant A. McArthur, FRACP; Victoria J. Mar, FACD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1322. doi:10.1001/jamadermatol.2019.2658

Lymphatic and Hematogenous Dissemination in Patients With Primary Cutaneous Melanoma鈥擱eply

Eduardo Nagore, MD, PhD; Rajiv Kumar, MD, PhD
Abstract Full Text
JAMA Dermatol. 2019;155(11):1323. doi:10.1001/jamadermatol.2019.2329
Correction

Error in Corresponding Authorship

Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1323. doi:10.1001/jamadermatol.2019.3435

Error in Title of Letter to the Editor

Abstract Full Text
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JAMA Dermatol. 2019;155(11):1323. doi:10.1001/jamadermatol.2019.3476
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2019;155(11):1215. doi:10.1001/jamadermatol.2018.3544
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