In reply

One does not have to be a rocket scientist or even have a PhD degree to figure out that vascular invasion by cells of melanoma is not a good prognostic sign; therefore, it came as no surprise that the results of their "Study" published in the ARCHIVES under the title "Vascular Involvement in the Prognosis of Primary Cutaneous Melanoma" prompted Kashani-Sabet et al ¹ to conclude the following:

The results of our analysis clearly indicate the independent role of vascular involvement in the prognostic assessment of patients with melanoma. The presence of vascular involvement was associated with an increased risk of melanoma relapse and death. Interestingly, involvement of the tumor vasculature, which is believed to represent largely lymphatic vessels, was predictive of distant as well as regional nodal metastases.