BY GEORGE HENRY FOX, A.M., M.D.

Of the medical treatment of acne, little need be said. . . . In the local treatment of acne, judging from the text-books, little advancement has been made in recent years. . . . If I were asked to give the practical treatment of this disease in the fewest possible words, I would simply recommend a strict diet, cold baths, systematic exercise, and the frequent use of the curette.

J Cutan Dis. 1903;21:136-141

Until fairly recently the evolution of an acne treatment strategy has been more by serendipity. W. J. Cunliffe

We believe that punctuational change dominates the history of life: evolution is concentrated in very rapid events. S. J. Gould and N. Eldridge