A 40-year-old white man presented with an acute bilateral periorbital eruption 8 years after undergoing a cardiac transplantation. He related the onset of eyelid pruritus to the initiation of pravastatin therapy. Subsequent erythema, crusting, and edema prompted a dermatologic evaluation. He denied constitutional symptoms. Occupational exposures included frequent hand washing and the use of vinyl gloves. He had a history of eyelid irritant dermatitis, which was under control. One week before the onset of the eruption, the dosage of his mycophenolate mofetil therapy had been increased from 1 to 1.5 g/d.