Contributions of the Framingham Heart Study to the Epidemiology of Coronary Heart Disease

George Chen; Daniel Levy

doi:10.1001/jamacardio.2016.2050

Dawber 聽TR, Meadors 聽GF, Moore 聽FE 聽Jr. 聽Epidemiological approaches to heart disease: the Framingham Study.聽聽Am J Public Health Nations Health. 1951;41(3):279-281.

Feinleib 聽M, Kannel 聽WB, Garrison 聽RJ, McNamara 聽PM, Castelli 聽WP. 聽The Framingham Offspring Study: design and preliminary data.聽聽Prev Med. 1975;4(4):518-525.

Splansky 聽GL, Corey 聽D, Yang 聽Q, 聽et al. 聽The Third Generation Cohort of the National Heart, Lung, and Blood Institute鈥檚 Framingham Heart Study: design, recruitment, and initial examination.聽聽Am J Epidemiol. 2007;165(11):1328-1335.

Cupples 聽LA, Arruda 聽HT, Benjamin 聽EJ, 聽et al. 聽The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.聽聽BMC Med Genet. 2007;8(suppl 1):S1.

National Heart, Lung, and Blood Institute. SHARe: SNP Health Association Resource. . Updated September 2011. Accessed March 1, 2016.

Oppenheimer 聽GM. 聽Becoming the Framingham Study 1947-1950.聽聽Am J Public Health. 2005;95(4):602-610.

Minutes 聽MF. October 14-15, 1949. Located at: Records of the National Institutes of Health, National Advisory Heart Council, Box 21, National Archives, College Park, MD.

Wong 聽ND, Levy 聽D. 聽Legacy of the Framingham Heart Study: rationale, design, initial findings, and implications.聽聽Glob Heart. 2013;8(1):3-9.

Dawber 聽TR, Moore 聽FE, Mann 聽GV. 聽Coronary heart disease in the Framingham Study.聽聽Am J Public Health Nations Health. 1957;47(4, pt 2):4-24.

10.

Dawber 聽TR, Kannel 聽WB, Revotskie 聽N, Stokes 聽J 聽III, Kagan 聽A, Gordon 聽T. 聽Some factors associated with the development of coronary heart disease: six years鈥� follow-up experience in the Framingham Study.聽聽Am J Public Health Nations Health. 1959;49:1349-1356.

11.

Kannel 聽WB, Dawber 聽TR, Kagan 聽A, Revotskie 聽N, Stokes 聽J 聽III. 聽Factors of risk in the development of coronary heart disease鈥攕ix-year follow-up experience: the Framingham Study.聽聽Ann Intern Med. 1961;55:33-50.

12.

聽Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg.聽听闯础惭础. 1967;202(11):1028-1034.

13.

聽The Lipid Research Clinics Coronary Primary Prevention Trial results, I: reduction in incidence of coronary heart disease.聽听闯础惭础. 1984;251(3):351-364.

14.

James 聽PA, Oparil 聽S, Carter 聽BL, 聽et al. 聽2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).聽听闯础惭础. 2014;311(5):507-520.

15.

Stone 聽NJ, Robinson 聽JG, Lichtenstein 聽AH, 聽et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 聽2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.聽听颁颈谤肠耻濒补迟颈辞苍. 2014;129(25)(suppl 2):S1-S45.

16.

Kannel 聽WB, McGee 聽D, Gordon 聽T. 聽A general cardiovascular risk profile: the Framingham Study.聽聽Am J Cardiol. 1976;38(1):46-51.

17.

Anderson 聽KM, Odell 聽PM, Wilson 聽PWF, Kannel 聽WB. 聽Cardiovascular disease risk profiles.聽聽Am Heart J. 1991;121(1, pt 2):293-298.

18.

Wilson 聽PW, D鈥橝gostino 聽RB, Levy 聽D, Belanger 聽AM, Silbershatz 聽H, Kannel 聽WB. 聽Prediction of coronary heart disease using risk factor categories.聽听颁颈谤肠耻濒补迟颈辞苍. 1998;97(18):1837-1847.

19.

聽The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC V).聽聽Arch Intern Med. 1993;153(2):154-183.

20.

National Cholesterol Education Program. 聽National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II).聽听颁颈谤肠耻濒补迟颈辞苍. 1994;89(3):1333-1445.

21.

D鈥橝gostino 聽RB 聽Sr, Grundy 聽S, Sullivan 聽LM, Wilson 聽P; CHD Risk Prediction Group. 聽Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation.聽听闯础惭础. 2001;286(2):180-187.

22.

Goff 聽DC 聽Jr, Lloyd-Jones 聽DM, Bennett 聽G, 聽et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 聽2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.聽听颁颈谤肠耻濒补迟颈辞苍. 2014;129(25)(suppl 2):S49-S73.

23.

Lloyd-Jones 聽DM, Wilson 聽PW, Larson 聽MG, 聽et al. 聽Framingham risk score and prediction of lifetime risk for coronary heart disease.聽聽Am J Cardiol. 2004;94(1):20-24.

24.

Pencina 聽MJ, D鈥橝gostino 聽RB 聽Sr, Larson 聽MG, Massaro 聽JM, Vasan 聽RS. 聽Predicting the 30-year risk of cardiovascular disease: the Framingham Heart Study.聽听颁颈谤肠耻濒补迟颈辞苍. 2009;119(24):3078-3084.

25.

Cupples 聽LA, D鈥橝gostino 聽RB, Anderson 聽K, Kannel 聽WB. 聽Comparison of baseline and repeated measure covariate techniques in the Framingham Heart Study.聽聽Stat Med. 1988;7(1-2):205-222.

26.

Kannel 聽WB, Wolf 聽PA, Garrison 聽RJ. 聽Monograph Section 34: Some Risk Factors Related to the Annual Incidence of Cardiovascular Disease and Death Using Pooled Repeated Biennial Measurements: Framingham Heart Study, 30-Year Follow-Up. Springfield, MA: National Technical Information Service; 1987:1-459.

27.

D鈥橝gostino 聽RB, Russell 聽MW, Huse 聽DM, 聽et al. 聽Primary and subsequent coronary risk appraisal: new results from the Framingham study.聽聽Am Heart J. 2000;139(2, pt 1):272-281.

28.

Kannel 聽WB, Gordon 聽T, Offutt 聽D. 聽Left ventricular hypertrophy by electrocardiogram: prevalence, incidence, and mortality in the Framingham Study.聽聽Ann Intern Med. 1969;71(1):89-105.

29.

Kannel 聽WB, Gordon 聽T, Castelli 聽WP, Margolis 聽JR. 聽Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease: the Framingham Study.聽聽Ann Intern Med. 1970;72(6):813-822.

30.

Kannel 聽WB. 聽Prevalence and natural history of electrocardiographic left ventricular hypertrophy.聽聽Am J Med. 1983;75(3A):4-11.

31.

Levy 聽D, Labib 聽SB, Anderson 聽KM, Christiansen 聽JC, Kannel 聽WB, Castelli 聽WP. 聽Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy.聽听颁颈谤肠耻濒补迟颈辞苍. 1990;81(3):815-820.

32.

Feigenbaum 聽H. 聽Evolution of echocardiography.聽听颁颈谤肠耻濒补迟颈辞苍. 1996;93(7):1321-1327.

33.

Levy 聽D, Savage 聽DD, Garrison 聽RJ, Anderson 聽KM, Kannel 聽WB, Castelli 聽WP. 聽Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study.聽聽Am J Cardiol. 1987;59(9):956-960.

34.

Levy 聽D, Garrison 聽RJ, Savage 聽DD, Kannel 聽WB, Castelli 聽WP. 聽Left ventricular mass and incidence of coronary heart disease in an elderly cohort: the Framingham Heart Study.聽聽Ann Intern Med. 1989;110(2):101-107.

35.

Levy 聽D, Garrison 聽RJ, Savage 聽DD, Kannel 聽WB, Castelli 聽WP. 聽Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.聽聽N Engl J Med. 1990;322(22):1561-1566.

36.

Havlik 聽RJ, Garrison 聽RJ, Feinleib 聽M, Kannel 聽WB, Castelli 聽WP, McNamara 聽PM. 聽Blood pressure aggregation in families.聽聽Am J Epidemiol. 1979;110(3):304-312.

37.

Garrison 聽RJ, Castelli 聽WP, Feinleib 聽M, 聽et al. 聽The association of total cholesterol, triglycerides and plasma lipoprotein cholesterol levels in first degree relatives and spouse pairs.聽聽Am J Epidemiol. 1979;110(3):313-321.

38.

Chesebro 聽JH, Fuster 聽V, Elveback 聽LR, Frye 聽RL. 聽Strong family history and cigarette smoking as risk factors of coronary artery disease in young adults.聽聽Br Heart J. 1982;47(1):78-83.

39.

Schildkraut 聽JM, Myers 聽RH, Cupples 聽LA, Kiely 聽DK, Kannel 聽WB. 聽Coronary risk associated with age and sex of parental heart disease in the Framingham Study.聽聽Am J Cardiol. 1989;64(10):555-559.

40.

Larson 聽MG, Atwood 聽LD, Benjamin 聽EJ, 聽et al. 聽Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.聽聽BMC Med Genet. 2007;8(suppl 1):S5.

41.

Psaty 聽BM, O鈥橠onnell 聽CJ, Gudnason 聽V, 聽et al; CHARGE Consortium. 聽Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: design of prospective meta-analyses of genome-wide association studies from 5 cohorts.聽聽Circ Cardiovasc Genet. 2009;2(1):73-80.

42.

Ehret 聽GB, Munroe 聽PB, Rice 聽KM, 聽et al; International Consortium for Blood Pressure Genome-Wide Association Studies; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen Consortium; EchoGen consortium; CHARGE-HF consortium. 聽Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.聽听狈补迟耻谤别. 2011;478(7367):103-109.

43.

Schunkert 聽H, K枚nig 聽IR, Kathiresan 聽S, 聽et al; Cardiogenics; CARDIoGRAM Consortium. 聽Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.聽聽Nat Genet. 2011;43(4):333-338.

44.

Musunuru 聽K, Strong 聽A, Frank-Kamenetsky 聽M, 聽et al. 聽From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.聽听狈补迟耻谤别. 2010;466(7307):714-719.

45.

Huan 聽T, Zhang 聽B, Wang 聽Z, 聽et al; Coronary ARteryDIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) Consortium, International Consortium for Blood Pressure GWAS (ICBP). 聽A systems biology framework identifies molecular underpinnings of coronary heart disease.聽聽Arterioscler Thromb Vasc Biol. 2013;33(6):1427-1434.

46.

Joehanes 聽R, Ying 聽S, Huan 聽T, 聽et al. 聽Gene expression signatures of coronary heart disease.聽聽Arterioscler Thromb Vasc Biol. 2013;33(6):1418-1426.

47.

Huan 聽T, Rong 聽J, Tanriverdi 聽K, 聽et al. 聽Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.聽聽Arterioscler Thromb Vasc Biol. 2015;35(4):1011-1021.

48.

Yao 聽C, Chen 聽BH, Joehanes 聽R, 聽et al. 聽Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.聽听颁颈谤肠耻濒补迟颈辞苍. 2015;131(6):536-549.

49.

Whitman 聽IR, Pletcher 聽MJ, Vittinghoff 聽E, 聽et al. 聽Perceptions, information sources, and behavior regarding alcohol and heart health.聽聽Am J Cardiol. 2015;116(4):642-646.

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Contributions of the Framingham Heart Study to the Epidemiology of Coronary Heart Disease

骋别辞谤驳别听颁丑别苍,听叠厂^1,2; 顿补苍颈别濒听尝别惫测,听惭顿^1,2,3

Author Affiliations Article Information

¹Framingham Heart Study, Framingham, Massachusetts
²Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
³Boston University School of Medicine, Boston, Massachusetts

JAMA Cardiol. 2016;1(7):825-830. doi:10.1001/jamacardio.2016.2050

Abstract

Since its launch in 1948, the Framingham Heart Study has proved critical to shaping and enhancing our understanding of the history and root causes of coronary heart disease (CHD). A modern prototype for population-based studies, the Framingham Heart Study garnered widespread recognition in its early years for identifying risk factors for CHD and stroke and formulating CHD risk scores. Although the study remains iconic for its robust design and successes in uncovering risk factors for CHD, it has undergone transformations during the past 2 decades. The 21st century ushered in a new era in 鈥渕olecular epidemiology鈥� centered on cutting-edge genetic and 鈥�-omics technologies.鈥� Framingham Heart Study investigators embraced these opportunities by pioneering genome-wide association studies at the population level and examining CHD through the lens of genetic variation, gene expression, and microRNA signatures. The Framingham Heart Study continues to evolve as it seeks to pinpoint new causes of disease with the hope of advancing personalized approaches to the treatment and prevention of CHD.

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Contributions of the Framingham Heart Study to the Epidemiology of Coronary Heart Disease