In Reply We thank Antonopoulos et al for their letter and in particular for highlighting the importance of microvascular complications in patients with diabetes. Risk stratification remains challenging in patients with type 2 diabetes because of the complex interplay between underlying pathologic processes. Microvascular disease (eg, nephropathy, retinopathy, and neuropathy) is both a complication of diabetes and a well-established risk factor for future complications, including renal failure, heart failure, and death.1,2