July 12, 2022 Issue of JAMA

July 12, 2022, Vol 328, No. 2, Pages 105-222

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2022;328(2):e2117044. doi:10.1001/jama.2021.17044

Podcast: Pharmacogenomic Testing for Major Depressive Disorder, Respiratory Support in Acutely Ill Children, Adverse Event Rates in Hospitalized Patients, and more

Original Investigation

Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial

David W. Oslin, MD; Kevin G. Lynch, PhD; Mei-Chiung Shih, PhD; et al.

Abstract Full Text

free access

JAMA. 2022;328(2):151-161. doi:10.1001/jama.2022.9805

This randomized clinical trial compares the efficacy of treatment guided by pharmacogenomic testing vs usual care to determine whether pharmacogenomic testing affects antidepressant medication selection and whether such testing leads to better clinical outcomes among patients with major depressive disorder (MDD).

Editorial
Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress
Dan V. Iosifescu, MD, MSc

JAMA

Caring for the Critically Ill Patient

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial

Padmanabhan Ramnarayan, MD; Alvin Richards-Belle, BSc; Laura Drikite, MSc; et al.

Abstract Full Text

free access

JAMA. 2022;328(2):162-172. doi:10.1001/jama.2022.9615

This randomized clinical trial assesses whether high-flow nasal cannula therapy is noninferior to continuous positive airway pressure for time to liberation from respiratory support among acutely ill children clinically assessed to require noninvasive respiratory support in pediatric critical care units.

Trends in Adverse Event Rates in Hospitalized Patients, 2010-2019

Noel Eldridge, MS; Yun Wang, PhD; Mark Metersky, MD; et al.

Abstract Full Text

free access has audio

JAMA. 2022;328(2):173-183. doi:10.1001/jama.2022.9600

This serial cross-sectional study used data from the Medicare Patient Safety Monitoring System for 2010 to 2019 to determine the change in the rate of adverse events in hospitalized patients.

Podcast: Progress in Adverse Event Rates in US Hospitalized Patients

Editorial
Improvements in Hospital Adverse Event Rates: Achieving Statistically Significant and Clinically Meaningful Results
William V. Padula, PhD; Peter J. Pronovost, MD, PhD

JAMA
- Podcast: Progress in Adverse Event Rates in US Hospitalized Patients

Research Letter

Comparison of an Emoji-Based Visual Analog Scale With a Numeric Rating Scale for Pain Assessment

Shuhan He, MD; Angela Renne, BS; Dias Argandykov, MD; et al.

Abstract Full Text

free access

JAMA. 2022;328(2):208-209. doi:10.1001/jama.2022.7489

This study surveyed patients admitted to the emergency department or surgical units at a single hospital to compare an emoji-based pain scale with a conventional numeric rating scale.

Association Between COVID-19 Booster Vaccination and Omicron Infection in a Highly Vaccinated Cohort of Players and Staff in the National Basketball Association

Caroline G. Tai, PhD, MPH; Lisa L. Maragakis, MD, MPH; Sarah Connolly, PhD, MPH; et al.

Abstract Full Text

free access

JAMA. 2022;328(2):209-211. doi:10.1001/jama.2022.9479

This study compares the incidence of SARS-CoV-2 infection in players and staff of the National Basketball Association (NBA) who did vs those who did not receive a COVID-19 vaccine booster dose.

Special Communication

Spirituality in Serious Illness and Health

Tracy A. Balboni, MD, MPH; Tyler J. VanderWeele, PhD; Stephanie D. Doan-Soares, DrPH; et al.

Abstract Full Text

has active quiz

JAMA. 2022;328(2):184-197. doi:10.1001/jama.2022.11086

This systematic review, analysis, and process study uses available evidence and expert consensus to provide suggested implications for addressing spirituality in serious illness and health outcomes as part of person-centered, value-sensitive care.

Viewpoint

Monkeypox in 2022鈥擶hat Clinicians Need to Know

Jeannette Guarner, MD; Carlos del Rio, MD; Preeti N. Malani, MD, MSJ

Abstract Full Text

free access has audio

JAMA. 2022;328(2):139-140. doi:10.1001/jama.2022.10802

This Viewpoint summarizes current knowledge of the 2022 monkeypox virus outbreak and the pathology, symptoms, diagnosis, prevention measures, and treatment options for monkeypox infection.

Podcast: Diagnosis, Prevention, and Treatment of Monkeypox
Podcast: Update on Monkeypox

Reducing SARS-CoV-2 in Shared Indoor Air

Deborah Dowell, MD, MPH; William G. Lindsley, PhD; John T. Brooks, MD

Abstract Full Text

free access

JAMA. 2022;328(2):141-142. doi:10.1001/jama.2022.9970

This Viewpoint discusses incorporating indoor air ventilation, filtration, and disinfection measures as part of community-level SARS-CoV-2 transmission reduction efforts.

Diagnostic Excellence

Measuring Performance of the Diagnostic Process

Helen Burstin, MD, MPH; Karen Cosby, MD

Abstract Full Text

JAMA. 2022;328(2):143-144. doi:10.1001/jama.2022.10166

This Viewpoint posits that to improve the diagnostic process, standards should be set for minimally acceptable diagnostic performance and actionable, timely, and meaningful information should be gained from measurement.

A Piece of My Mind

Baby Girl

Mollie C. Marr, PhD

Abstract Full Text

JAMA. 2022;328(2):145. doi:10.1001/jama.2022.10578

In this narrative medicine essay, a fourth-year medical student reimagines her first weeks of life before adoption during her pediatrics rotation when she and the medical care team poured love and attention on another baby girl waiting for foster care placement.

Editorial

Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress

Dan V. Iosifescu, MD, MSc

Abstract Full Text

JAMA. 2022;328(2):146-148. doi:10.1001/jama.2022.10018

Improvements in Hospital Adverse Event Rates: Achieving Statistically Significant and Clinically Meaningful Results

William V. Padula, PhD; Peter J. Pronovost, MD, PhD

Abstract Full Text

has audio

JAMA. 2022;328(2):148-150. doi:10.1001/jama.2022.10281

Podcast: Progress in Adverse Event Rates in US Hospitalized Patients

JAMA Clinical Challenge

Chronic Abdominal Pain and Anemia in a 59-Year-Old Man

Takashi Oshima, MD; Kiyoshi Kinjo, MD, MS; Mitsuyo Kinjo, MD, MPH

Abstract Full Text

has active quiz

JAMA. 2022;328(2):198-199. doi:10.1001/jama.2022.9194

A 59-year-old man had 3 months of unexplained chronic diffuse abdominal pain. Results of upper and lower endoscopy, abdominal-pelvic CT, and urinalysis were unremarkable; hemoglobin level was 8.7 g/dL; peripheral blood smear showed basophilic stippling of erythrocytes; and physical examination showed bluish pigmentation along the gingival margin. What is the diagnosis and what would you do next?

Medical News & Perspectives

Highlights From the 2022 Annual Meeting of the American Society of Clinical Oncology鈥擠isparities in Clinical Trials, Mitigating Clinician Burnout, and Combination Treatments for Cancer

Melissa Suran, PhD, MSJ

Abstract Full Text

has audio

JAMA. 2022;328(2):117-119. doi:10.1001/jama.2022.9241

This Medical News article explores timely topics discussed at the American Society of Clinical Oncology鈥檚 2022 annual meeting.

Podcast: Highlights From the 2022 Annual Meeting of the American Society of Clinical Oncology

Quick Uptakes

COVID-19 mRNA Vaccine Booster During Pregnancy Increases Maternal and Fetal Antibodies

Jennifer Abbasi

Abstract Full Text

free access has active quiz has audio

JAMA. 2022;328(2):120-121. doi:10.1001/jama.2022.11145

This Medical News article discusses a recent study comparing SARS-CoV-2 antibody levels among pregnant people and their infants after 2 vs 3 doses of the BNT162b2 (Pfizer-BioNTech) mRNA vaccine.