October 4, 2022 Issue of JAMA

October 4, 2022, Vol 328, No. 13, Pages 1275-1362

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2022;328(13):e2117154. doi:10.1001/jama.2021.17154

Podcast: Antibiotics for Complicated Urinary Tract Infection, Telmisartan for Peripheral Artery Disease, Reducing Opioids After Arthroscopy, and more

Original Investigation

Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial

Keith S. Kaye, MD; Adam Belley, PhD; Philip Barth, PhD; et al.

Abstract Full Text

free access

JAMA. 2022;328(13):1304-1314. doi:10.1001/jama.2022.17034

This randomized clinical trial compares the efficacy of cefepime/enmetazobactam vs piperacillin/tazobactam in achieving overall treatment success in patients with complicated urinary tract infections (UTIs) or acute pyelonephritis.

Editorial
Cefepime/Enmetazobactam for Complicated Urinary Tract Infections
Sonali D. Advani, MBBS, MPH; Kimberly Claeys, PharmD

JAMA

Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease: The TELEX Randomized Clinical Trial

Mary M. McDermott, MD; Lydia Bazzano, MD, PhD; Charlotte A. Peterson, PhD; et al.

Abstract Full Text

free access has audio

JAMA. 2022;328(13):1315-1325. doi:10.1001/jama.2022.16797

This randomized clinical trial compares the effect of telmisartan on 6-minute walk distance compared with placebo in patients with lower extremity peripheral artery disease at 6-month follow-up.

Podcast: Treatment of Peripheral Artery Disease

Editorial
Telmisartan and Walking Performance in Peripheral Artery Disease
Marc P. Bonaca, MD, MPH; Connie Hess, MD, MHS; Joshua A. Beckman, MD

JAMA

Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial

The NO PAin Investigators

Abstract Full Text

free access has multimedia

JAMA. 2022;328(13):1326-1335. doi:10.1001/jama.2022.16844

This clinical trial compares the amount of opioids used by patients who underwent arthroscopic knee or shoulder surgery randomized to a pain management protocol involving patient education, nonsteroidal anti-inflammatories, and acetaminophen or to the current pain management care.

Video: Video Editor's Note: Effect of an Opioid-Sparing Protocol vs Standard Prescribing on Opioid Consumption After Knee or Shoulder Arthroscopy

Research Letter

Compassionate Use of Tecovirimat for the Treatment of Monkeypox Infection

Angel N. Desai, MD, MPH; George R. Thompson III, MD; Sonja M. Neumeister, MPH; et al.

Abstract Full Text

free access has active quiz has audio

JAMA. 2022;328(13):1348-1350. doi:10.1001/jama.2022.15336

This case series describes the clinical resolution of systemic symptoms and lesions, along with any adverse events, in patients with monkeypox infection who were treated with tecovirimat on a compassionate use basis.

Podcast: Update on Monkeypox

Medical Record Closure Practices of Physicians Before and After the Use of Medical Scribes

Sarah T. Florig, MS; Sky Corby, MS; Tanuj Devara, MS; et al.

Abstract Full Text

free access

JAMA. 2022;328(13):1350-1352. doi:10.1001/jama.2022.13558

This study uses electronic health record data to evaluate medical record closure outcomes before and after the use of medical scribes at a large academic medical center.

Viewpoint

Reflections on Integrins鈥擯ast, Present, and Future: The Albert Lasker Basic Medical Research Award

Richard O. Hynes, PhD; Erkki Ruoslahti, MD, PhD; Timothy A. Springer, PhD

Abstract Full Text

free access

JAMA. 2022;328(13):1291-1292. doi:10.1001/jama.2022.17005

This Viewpoint discusses the rapid advances in molecular cell biological approaches over the past 50 years and the many avenues for future advances that have been opened, including direct applications for therapeutic and regenerative medicine.

Discovery of Cell-Free Fetal DNA in Maternal Blood and Development of Noninvasive Prenatal Testing: 2022 Lasker-DeBakey Clinical Medical Research Award

Y. M. Dennis Lo, DM, DPhil

Abstract Full Text

free access

JAMA. 2022;328(13):1293-1294. doi:10.1001/jama.2022.14982

In this Viewpoint, 2022 Lasker-DeBakey Clinical Medical Research Award winner Y. M. Dennis Lo discusses his discovery and application of cell-free fetal DNA for noninvasive prenatal testing.

The COVID-19 Dashboard for Real-time Tracking of the Pandemic: The Lasker-Bloomberg Public Service Award

Lauren Gardner, PhD

Abstract Full Text

free access

JAMA. 2022;328(13):1295-1296. doi:10.1001/jama.2022.15590

In this Viewpoint, Lauren Gardner, winner of the 2022 Lasker-Bloomberg Public Service Award for creating the COVID-19 Dashboard, discusses the development of the Dashboard and the factors that contributed to its success.

A Piece of My Mind

Notes on Healing After a Missed Diagnosis

Elizabeth A. Fleming, MD

Abstract Full Text

JAMA. 2022;328(13):1297-1298. doi:10.1001/jama.2022.15724

In this narrative medicine essay, a family physician maintains her patient鈥檚 trust despite missing what could have been a catastrophic diagnosis because she apologized for her oversight.

Editorial

Cefepime/Enmetazobactam for Complicated Urinary Tract Infections

Sonali D. Advani, MBBS, MPH; Kimberly Claeys, PharmD

Abstract Full Text

JAMA. 2022;328(13):1299-1301. doi:10.1001/jama.2022.15228

Telmisartan and Walking Performance in Peripheral Artery Disease

Marc P. Bonaca, MD, MPH; Connie Hess, MD, MHS; Joshua A. Beckman, MD

Abstract Full Text

JAMA. 2022;328(13):1302-1303. doi:10.1001/jama.2022.14912

Review

Acute Pulmonary Embolism: A Review

Yonathan Freund, MD, PhD; Fleur Cohen-Aubart, MD, PhD; Ben Bloom, MD, PhD

Abstract Full Text

has active quiz has audio

JAMA. 2022;328(13):1336-1345. doi:10.1001/jama.2022.16815

This Review discusses the incidence, diagnosis, symptomatic characteristics, treatment, and prognosis for patients with pulmonary embolism.

Podcast: Diagnosis and Management of Acute Pulmonary Embolism

JAMA Clinical Guidelines Synopsis

Management of Heart Failure

Mark N. Belkin, MD; Adam S. Cifu, MD; Sean Pinney, MD

Abstract Full Text

has active quiz

JAMA. 2022;328(13):1346-1347. doi:10.1001/jama.2022.16667

This JAMA Clinical Guidelines Synopsis summarizes the 2022 ACC/AHA/HFSA guidelines for management of heart failure in adults with a diagnosis of or at risk for heart failure.

Medical News & Perspectives

Growing Role of Gabapentin in Opioid-Related Overdoses Highlights Misuse Potential and Off-label Prescribing Practices

Bridget M. Kuehn, MSJ

Abstract Full Text

has audio

JAMA. 2022;328(13):1283-1285. doi:10.1001/jama.2022.13659

This Medical News article discusses a trend of gabapentin misuse and harms, including fatal overdoses.

Podcast: September 2022 Medical News Summary

Dr Fauci and the Art of Science Communication

Melissa Suran, PhD, MSJ

Abstract Full Text

free access has multimedia has audio

JAMA. 2022;328(13):1286-1287. doi:10.1001/jama.2022.16280

Anthony Fauci, MD, who announced he will step down as chief medical advisor to US President Joe Biden and as director of the National Institute of Allergy and Infectious Diseases, discusses best practices for conveying scientific information to the public in a polarized era.