February 1, 2022 Issue of JAMA

February 1, 2022, Vol 327, No. 5, Pages 409-497

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2022;327(5):e2118023. doi:10.1001/jama.2021.18023

Podcast: Casirivimab and Imdevimab for Early Asymptomatic SARS-CoV-2 Infection, Hypothermia vs Normothermia for Cardiogenic Shock and Extracorporeal Membrane Oxygenation, Familial Idiopathic Dilated Cardiomyopathy, and more

Original Investigation

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

Meagan P. O鈥橞rien, MD; Eduardo Forleo-Neto, MD; Neena Sarkar, PhD; et al.

Abstract Full Text

free access has active quiz

JAMA. 2022;327(5):432-441. doi:10.1001/jama.2021.24939

This randomized trial assesses the effect of a single dose of subcutaneous casirivimab and imdevimab antibody combination vs placebo on 28-day progression to symptomatic COVID-19 among asymptomatic SARS-CoV-2 reverse transcriptase鈥搎uantitative polymerase chain reaction鈥損ositive individuals living with an infected household contact.

Editorial
Realizing the Potential of Anti鈥揝ARS-CoV-2 Monoclonal Antibodies for COVID-19 Management
Jonathan Z. Li, MD; Rajesh T. Gandhi, MD

JAMA

Caring for the Critically Ill Patient

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial

Bruno Levy, MD, PhD; Nicolas Girerd, MD, PhD; Julien Amour, MD, PhD; et al.

Abstract Full Text

free access has active quiz

JAMA. 2022;327(5):442-453. doi:10.1001/jama.2021.24776

This randomized clinical trial compares the effect of early use of moderate hypothermia (33-34 掳C) vs strict normothermia (36-37 掳C) on mortality in patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation (ECMO).

Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy

Gordon S. Huggins, MD; Daniel D. Kinnamon, PhD; Garrie J. Haas, MD; et al.

Abstract Full Text

free access has active quiz

JAMA. 2022;327(5):454-463. doi:10.1001/jama.2021.24674

This study aims to estimate the prevalence of familial dilated cardiomyopathy (DCM) among DCM probands and the age-specific cumulative risk of DCM in first-degree relatives across race and ethnicity groups.

Editorial
Identifying Dilated Cardiomyopathy Through Family-Based Screening
Krishna G. Aragam, MD, MS

JAMA

Research Letter

Trends in Use of Melatonin Supplements Among US Adults, 1999-2018

Jingen Li, MD, PhD; Virend K. Somers, MD, PhD; Hao Xu, MD, PhD; et al.

Abstract Full Text

free access

JAMA. 2022;327(5):483-485. doi:10.1001/jama.2021.23652

This study examines reported prevalence and trends in use of melatonin supplements among US adults from 1999 through 2018.

False-Positive Results in Rapid Antigen Tests for SARS-CoV-2

Joshua S. Gans, PhD; Avi Goldfarb, PhD; Ajay K. Agrawal, PhD; et al.

Abstract Full Text

free access has active quiz

JAMA. 2022;327(5):485-486. doi:10.1001/jama.2021.24355

This study examines the incidence of false-positive results in a sample of rapid antigen tests used to serially screen asymptomatic workers throughout Canada.

Viewpoint

Improving Traumatic Brain Injury Care and Research: A Report From the National Academies of Sciences, Engineering, and Medicine

Katherine Bowman, PhD; Chanel Matney, PhD; Donald M. Berwick, MD, MPP

Abstract Full Text

JAMA. 2022;327(5):419-420. doi:10.1001/jama.2022.0089

This Viewpoint describes a report from the National Academies of Sciences, Engineering, and Medicine about postinjury care for traumatic brain injury (TBI), with the aims of reducing associated disability and morbidity and enhancing the value and effectiveness of TBI care.

Mitigating the Long-term Health Risks of Adverse Pregnancy Outcomes

Lynn M. Yee, MD, MPH; Eliza C. Miller, MD, MS; Philip Greenland, MD

Abstract Full Text

has audio

JAMA. 2022;327(5):421-422. doi:10.1001/jama.2021.23870

This Viewpoint discusses the increased long-term risks for cardiovascular disease among individuals who have had adverse pregnancy outcomes and describes mitigation strategies for physicians to use over the life span of these patients.

Podcast: Adverse Pregnancy Outcomes and Long-term Health Risks

Hierarchical Payment Models鈥擜 Path for Coordinating Population- and Episode-Based Payment Models

William H. Shrank, MD, MSHS; Michael E. Chernew, PhD; Amol S. Navathe, MD, PhD

Abstract Full Text

JAMA. 2022;327(5):423-424. doi:10.1001/jama.2021.23786

This Viewpoint discusses the implications from data on value-based payments, policy design regarding population- and episode-based payments, and the benefits of coordinated payment models that may contribute toward reaching the Centers for Medicare & Medicaid Services鈥� strategy, announced in November 2021, for achieving near-universal participation in value-based payment models by 2030.

A Piece of My Mind

The Language of Failure

Iris T. Lee, MD

Abstract Full Text

JAMA. 2022;327(5):425-426. doi:10.1001/jama.2021.24985

In this narrative medicine essay, a reproductive endocrinology fellow undergoing IVF considers the harmful effect of the language of failure, a term often used in medicine when a treatment is ineffective.

Editorial

Realizing the Potential of Anti鈥揝ARS-CoV-2 Monoclonal Antibodies for COVID-19 Management

Jonathan Z. Li, MD; Rajesh T. Gandhi, MD

Abstract Full Text

free access has active quiz

JAMA. 2022;327(5):427-429. doi:10.1001/jama.2021.19994

Identifying Dilated Cardiomyopathy Through Family-Based Screening

Krishna G. Aragam, MD, MS

Abstract Full Text

JAMA. 2022;327(5):430-431. doi:10.1001/jama.2021.23960

Review

Diagnosis and Management of Multiple Myeloma: A Review

Andrew J. Cowan, MD; Damian J. Green, MD; Mary Kwok, MD; et al.

Abstract Full Text

has active quiz has audio

JAMA. 2022;327(5):464-477. doi:10.1001/jama.2022.0003

This narrative review summarizes current evidence regarding the epidemiology, clinical presentation, diagnosis, and management of multiple myeloma.

Podcast: Diagnosis and Management of Multiple Myeloma

JAMA Insights

Clinical Update

Dry Eye Disease: An Update in 2022

Farida E. Hakim, MD; Asim V. Farooq, MD

Abstract Full Text

has active quiz

JAMA. 2022;327(5):478-479. doi:10.1001/jama.2021.19963

This JAMA Insights describes dry eye disease and summarizes its types, pathology, diagnosis, and treatment.

JAMA Diagnostic Test Interpretation

Diffusing Capacity of the Lungs for Carbon Monoxide Test

Neil MacIntyre, MD; Aparna Balasubramanian, MD; David Kaminsky, MD

Abstract Full Text

has active quiz

JAMA. 2022;327(5):480-481. doi:10.1001/jama.2021.24323

A 62-year-old man presented with a 4- to 6-month history of increasing exertional dyspnea. His measured hemoglobin was 15.3 g/dL and diffusing capacity of the lungs for carbon monoxide was 9.80 mL/min/mm Hg. How would you interpret these test results?

Medical News & Perspectives

Preparing Hospitals鈥� Medical Oxygen Delivery Systems for a Respiratory 鈥淭windemic鈥�

Melissa Suran, PhD, MSJ

Abstract Full Text

free access has audio

JAMA. 2022;327(5):411-413. doi:10.1001/jama.2021.23392

This Medical News feature examines the challenges that hospitals face as they prepare for a spike in severe cases of COVID-19 and other respiratory illnesses that require supplemental oxygen.