April 19, 2022 Issue of JAMA

April 19, 2022, Vol 327, No. 15, Pages 1421-1514

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2022;327(15):e2116933. doi:10.1001/jama.2021.16933

Podcast: Corticosteroids for Duchenne Muscular Dystrophy, Pregnancy Outcomes After SARS-CoV-2 Vaccination, Association of Race and Ethnicity With Dementia, and more

Original Investigation

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial

Michela Guglieri, MD; Kate Bushby, MD; Michael P. McDermott, PhD; et al.

Abstract Full Text

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JAMA. 2022;327(15):1456-1468. doi:10.1001/jama.2022.4315

This randomized clinical trial compares the efficacy and adverse effects of the 3 most frequently prescribed corticosteroid regimens for boys with Duchenne muscular dystrophy.

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes

Maria C. Magnus, PhD; Anne K. Örtqvist, MD, PhD; Elisabeth Dahlqwist, PhD; et al.

Abstract Full Text

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JAMA. 2022;327(15):1469-1477. doi:10.1001/jama.2022.3271

This cohort study examines the risk of adverse pregnancy outcomes after vaccination against SARS-CoV-2 during pregnancy based on registry data from Sweden and Norway.

Editorial
COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy
Elyse O. Kharbanda, MD, MPH; Gabriela Vazquez-Benitez, PhD

JAMA

Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes

Deshayne B. Fell, PhD; Tavleen Dhinsa, MSc; Gillian D. Alton, PhD; et al.

Abstract Full Text

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JAMA. 2022;327(15):1478-1487. doi:10.1001/jama.2022.4255

This population-based cohort study examines the association between COVID-19 vaccination during pregnancy and maternal and neonatal peripartum outcomes just before, during, or after delivery.

Editorial
COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy
Elyse O. Kharbanda, MD, MPH; Gabriela Vazquez-Benitez, PhD

JAMA

Association of Race and Ethnicity With Incidence of Dementia Among Older Adults

Erica Kornblith, PhD; Amber Bahorik, PhD; W. John Boscardin, PhD; et al.

Abstract Full Text

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JAMA. 2022;327(15):1488-1495. doi:10.1001/jama.2022.3550

This study evaluated racial and ethnic and regional differences in dementia risk within a large, diverse national cohort of older adults receiving care in the Veterans Health Administration.

Editorial
Association of Race and Ethnicity With Dementia
Gwen Yeo, PhD

JAMA

Research Letter

Health Risk Factors and Outcomes Among Gender Minority High School Students in 15 US States

Gilbert Gonzales, PhD, MHA; Cameron Deal

Abstract Full Text

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JAMA. 2022;327(15):1498-1500. doi:10.1001/jama.2022.3087

This study uses state data sets from the 2017 and 2019 Youth Risk Behavior Survey to assess health risk factors and health outcomes by gender identity among a large, population-based sample of gender minority adolescents.

COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance

Emily H. Adhikari, MD; Lorre MacDonald, CNM; Jeffrey A. SoRelle, MD; et al.

Abstract Full Text

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JAMA. 2022;327(15):1500-1502. doi:10.1001/jama.2022.4356

This study examines infections, illness severity, vaccinations, and early neonatal infections among obstetric patients during the pre-Delta, Delta, and Omicron periods of the COVID-19 pandemic.

Viewpoint

Reducing 鈥淐OVID-19 Misinformation鈥� While Preserving Free Speech

William M. Sage, MD, JD; Y. Tony Yang, ScD, LLM, MPH

Abstract Full Text

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JAMA. 2022;327(15):1443-1444. doi:10.1001/jama.2022.4231

This Viewpoint discusses actions that health care leaders and policy makers can take to better assess the likely constitutionality of reducing 鈥淐OVID misinformation鈥� through government prohibitions or sanctions.

Podcast: Reducing 鈥淐OVID-19 Misinformation鈥� While Preserving Free Speech

Medical Need, Financial Resources, and Transplant Accessibility

Sharad I. Wadhwani, MD, MPH; Jennifer C. Lai, MD, MBA; Laura M. Gottlieb, MD, MPH

Abstract Full Text

JAMA. 2022;327(15):1445-1446. doi:10.1001/jama.2022.5283

This Viewpoint demonstrates that the financial measures used to place patients on the transplant waiting list is an example of structural racism and offers 3 policy shifts to address those inequities.

Enhancing HIV Prevention With New Modalities and Routine Sexual History Discussions

Kenneth H. Mayer, MD; Lao-Tzu Allan-Blitz, MD

Abstract Full Text

JAMA. 2022;327(15):1447-1448. doi:10.1001/jama.2022.3848

This Viewpoint highlights the recent CDC updates to preexposure prophylaxis (PrEP) for individuals at risk for HIV and the implications for US clinicians.

A Piece of My Mind

Goals of Care

Julie W. Childers, MD

Abstract Full Text

JAMA. 2022;327(15):1449-1450. doi:10.1001/jama.2022.4619

In this narrative medicine essay, a palliative care physician struggles with her role as physician and as daughter during her elderly parents鈥� final days.

Editorial

COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy

Elyse O. Kharbanda, MD, MPH; Gabriela Vazquez-Benitez, PhD

Abstract Full Text

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JAMA. 2022;327(15):1451-1453. doi:10.1001/jama.2022.2459

Association of Race and Ethnicity With Dementia

Gwen Yeo, PhD

Abstract Full Text

JAMA. 2022;327(15):1454-1455. doi:10.1001/jama.2022.4473

JAMA Clinical Challenge

Fever, Hypotension, and a Worsening Necrotic Wound

Danielle M. Peterson, MD; William E. Damsky, MD, PhD; Matthew D. Vesely, MD, PhD

Abstract Full Text

has active quiz

JAMA. 2022;327(15):1496-1497. doi:10.1001/jama.2022.2806

A woman had a large, deep ulcer at an injection site on her thigh, with a dusky violaceous border extending 2 to 5 cm from the wound edge, fever to 39.8 掳C, and elevated white blood cell count and procalcitonin level; histologic examination of excised tissue showed a dense pan-dermal neutrophilic infiltrate, and multiple blood and tissue cultures were negative. What is the diagnosis and what would you do next?

Medical News & Perspectives

Air Quality and Brain Health

Anita Slomski

Abstract Full Text

JAMA. 2022;327(15):1430-1431. doi:10.1001/jama.2022.3691

This Medical News article discusses studies examining associations of air pollution and cognitive health.

Medical Groups Defend Patient-Physician Relationship and Access to Adolescent Gender-Affirming Care

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2022;327(15):1432-1434. doi:10.1001/jama.2022.4617

This Medical News article discusses physicians鈥� advocacy to protect patients and the patient-physician relationship amid efforts by politicians to limit access or criminalize gender-affirming care.

Pushed to Their Limits, 1 in 5 Physicians Intends to Leave Practice

Jennifer Abbasi

Abstract Full Text

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JAMA. 2022;327(15):1435-1437. doi:10.1001/jama.2022.5074

This Medical News article discusses burnout, financial stressors, and other factors driving physicians out of medicine during COVID-19.

News From the Food and Drug Administration

Manufacturer Ordered to Raise Awareness of Recalled Medical Devices

Rita Rubin, MA

Abstract Full Text

JAMA. 2022;327(15):1439. doi:10.1001/jama.2022.5596

First Symbicort Generic Gains Approval

Rita Rubin, MA

Abstract Full Text

JAMA. 2022;327(15):1439. doi:10.1001/jama.2022.5095

Warning About Surgical Device Misused for Aesthetic Procedures

Rita Rubin, MA

Abstract Full Text

JAMA. 2022;327(15):1439. doi:10.1001/jama.2022.5597

Global Health

Global COVID-19 Death Toll May Be Triple the Reported Deaths

Howard D. Larkin

Abstract Full Text

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JAMA. 2022;327(15):1438. doi:10.1001/jama.2022.4767

WHO Urges Monitoring SARS-CoV-2 in Wildlife to Prevent Animal Reservoirs

Howard D. Larkin

Abstract Full Text

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JAMA. 2022;327(15):1438. doi:10.1001/jama.2022.5654

Fractionating COVID-19 Vaccine Doses May Save Lives

Howard D. Larkin

Abstract Full Text

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JAMA. 2022;327(15):1438. doi:10.1001/jama.2022.5655

Poetry and Medicine

Open Heart

Zoe Onion

Abstract Full Text

JAMA. 2022;327(15):1508. doi:10.1001/jama.2022.1810

JAMA Revisited

The Digestion of Sugar

Abstract Full Text

JAMA. 2022;327(15):1509. doi:10.1001/jama.2021.16934

JAMA Patient Page

Acute Cholecystitis

Kristin Walter, MD, MS

Abstract Full Text

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JAMA. 2022;327(15):1514. doi:10.1001/jama.2022.2969

This JAMA Patient Page describes acute cholecystitis and its risk factors, diagnosis, and treatment.

Podcast: Acute Cholecystitis

Comment & Response

Use of a Bougie vs Endotracheal Tube With Stylet and Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation

Michael J. Brenner, MD; Brendan A. McGrath, MB, CHB, PhD; Tim M. Cook, MBBS

Abstract Full Text

JAMA. 2022;327(15):1502-1503. doi:10.1001/jama.2022.2710

Use of a Bougie vs Endotracheal Tube With Stylet and Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation

Kotaro Kida, MD, PhD; Yuki Sugimoto, MD; Tomohiko Sato, MD, PhD

Abstract Full Text

JAMA. 2022;327(15):1503. doi:10.1001/jama.2022.2713

Use of a Bougie vs Endotracheal Tube With Stylet and Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation鈥擱eply

Brian E. Driver, MD; Matthew E. Prekker, MD; Jonathan D. Casey, MD

Abstract Full Text

JAMA. 2022;327(15):1503-1504. doi:10.1001/jama.2022.2716

Selection, Effectiveness, and Adverse Effects of Contraception

Ekaterina Skaritanov, BS; Gianna Wilkie, MD; Lara C. Kovell, MD

Abstract Full Text

JAMA. 2022;327(15):1504. doi:10.1001/jama.2022.2854

Selection, Effectiveness, and Adverse Effects of Contraception鈥擱eply

Stephanie Teal, MD, MPH; Alison Edelman, MD, MPH

Abstract Full Text

JAMA. 2022;327(15):1505. doi:10.1001/jama.2022.2857

Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy and Control of Immune-Mediated Inflammatory Diseases

Eugen Javor, MPharm; Goran Hauser, MD, PhD; Marko Skelin, MPharm, PhD

Abstract Full Text

JAMA. 2022;327(15):1505-1506. doi:10.1001/jama.2022.2935

Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy and Control of Immune-Mediated Inflammatory Diseases

Niels Vande Casteele, PhD

Abstract Full Text

JAMA. 2022;327(15):1506. doi:10.1001/jama.2022.2932

Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy and Control of Immune-Mediated Inflammatory Diseases鈥擱eply

Silje Watterdal Syversen, MD, PhD; Jørgen Jahnsen, MD, PhD; Espen A. Haavardsholm, MD, PhD

Abstract Full Text

JAMA. 2022;327(15):1506-1507. doi:10.1001/jama.2022.2938

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April 19, 2022, Vol 327, No. 15, Pages 1421-1514

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