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November 2024 - July 1883

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April 5, 2022, Vol 327, No. 13, Pages 1209-1300

This Week in JAMA

Audio Highlights

Abstract Full Text
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JAMA. 2022;327(13):e2116913. doi:10.1001/jama.2021.16913
Original Investigation

Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial

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JAMA. 2022;327(13):1236-1246. doi:10.1001/jama.2022.2832

This randomized clinical trial compares the efficacy and adverse events of sotrovimab vs placebo in preventing progression of mild to moderate COVID-19 to severe disease.

Caring for the Critically Ill Patient

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

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JAMA. 2022;327(13):1247-1259. doi:10.1001/jama.2022.2910

This randomized clinical trial assesses the effect of treatment with an antiplatelet agent vs no antiplatelet therapy on days alive and free of intensive care unit respiratory or cardiovascular organ support within 21 days among patients critically ill with COVID-19.

Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction

Abstract Full Text
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JAMA. 2022;327(13):1260-1268. doi:10.1001/jama.2022.2540

This large prospective cohort study compares the rates of acute myocardial infarction between recipients of a 2-dose hepatitis B vaccine and recipients of a 3-dose hepatitis B vaccine.

Research Letter

Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada

Abstract Full Text
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JAMA. 2022;327(13):1286-1288. doi:10.1001/jama.2022.2274

This study examines hospitalizations and deaths associated with the SARS-CoV-2 Omicron variant compared with matched patients infected with the Delta variant.

Trends and Outcomes for Preimplantation Genetic Testing in the United States, 2014-2018

Abstract Full Text
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JAMA. 2022;327(13):1288-1290. doi:10.1001/jama.2022.1892

This study uses US national surveillance data to describe preimplantation genetic testing trends and outcomes between 2014 and 2018.

Viewpoint

Expanding Efforts and Support to Respond to the HIV and COVID-19 Intersecting Pandemics

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JAMA. 2022;327(13):1227-1228. doi:10.1001/jama.2022.3517

This Viewpoint discusses the generation of SARS-CoV-2 variants of concern globally and the need for increased access to COVID-19 vaccination in Africa, particularly for people living with HIV and for households and people living in densely populated communities.

SARS-CoV-2 Laboratory-Developed Tests: Integrity Restored

Abstract Full Text
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JAMA. 2022;327(13):1229-1230. doi:10.1001/jama.2022.3382

This Viewpoint reviews the regulatory oversight of laboratory-developed tests, discusses its recent policy permutations, and explores potential future considerations.

Patient Assistance Programs and the Anti-Kickback Statute: Charting a Pathway Forward

Abstract Full Text
JAMA. 2022;327(13):1231-1232. doi:10.1001/jama.2022.2043

This Viewpoint discusses how patient assistance programs help patients pay for expensive name-brand drugs, which help ensure profit, and recommends anti-kickback statutes be used to ensure the programs help those most in need.

A Piece of My Mind

A Love Letter to Grief

Abstract Full Text
JAMA. 2022;327(13):1233. doi:10.1001/jama.2022.3478

In this narrative medicine essay, a medical student explores the facets of her grief over her mother’s death as a daughter, a caretaker, and a medical student.

Editorial

Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status

Abstract Full Text
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JAMA. 2022;327(13):1234-1235. doi:10.1001/jama.2022.2361
Review

Antiseizure Medications for Adults With Epilepsy: A Review

Abstract Full Text
has active quiz has audio
JAMA. 2022;327(13):1269-1281. doi:10.1001/jama.2022.3880

This review article discusses the management of focal and generalized epilepsy in adults who respond to pharmacotherapy with antiseizure drugs, focusing on the most common types of epilepsy treated by general neurologists and primary care clinicians.

JAMA Guide to Statistics and Methods

Collider Bias

Abstract Full Text
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JAMA. 2022;327(13):1282-1283. doi:10.1001/jama.2022.1820

This JAMA Guide to Statistics and Methods describes collider bias, illustrates examples in directed acyclic graphs, and explains how it can threaten the internal validity of a study and the accurate estimation of causal relationships in randomized clinical trials and observational studies.

JAMA Diagnostic Test Interpretation

Cardiopulmonary Exercise Testing

Abstract Full Text
has active quiz
JAMA. 2022;327(13):1284-1285. doi:10.1001/jama.2022.2037

A 33-year-old man with intermittent asthma presented with 3 months of dyspnea on exertion, which developed approximately 2 weeks after infection with SARS-CoV-2. The patient demonstrated reduced exercise tolerance during cardiopulmonary testing, achieving only 64% of the predicted maximum rate of oxygen consumption. How do you interpret these test results?

Medical News & Perspectives

Center for Medicare Director Envisions Holistic Approach to Health Care

Abstract Full Text
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JAMA. 2022;327(13):1214-1215. doi:10.1001/jama.2022.4289

Deputy Administrator and Director of the Center for Medicare, Meena Seshamani, MD, PhD, discusses how to increase access to health care and improve delivery.

Quick Uptakes

Functional Brain Organization Differences Found Between Boys and Girls With Autism Spectrum Disorder

Abstract Full Text
JAMA. 2022;327(13):1216-1217. doi:10.1001/jama.2022.3834

This JAMA Medical News feature describes new research that found gender differences in the brains of children with autism spectrum disorder.

News From the ÌÇÐÄvlog

Maternal COVID-19 Vaccine Safe for Infants

Abstract Full Text
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JAMA. 2022;327(13):1218. doi:10.1001/jama.2022.4370

At-home COVID-19 Test Instructions Frequently Misinterpreted

Abstract Full Text
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JAMA. 2022;327(13):1218. doi:10.1001/jama.2022.3350

While Suicide Attempts Have Increased, Treatment Has Not

Abstract Full Text
JAMA. 2022;327(13):1218. doi:10.1001/jama.2022.4371

Few Black Individuals Are Becoming Surgeons

Abstract Full Text
JAMA. 2022;327(13):1218. doi:10.1001/jama.2022.4372
News From the Food and Drug Administration

First Condom Authorized Specifically for Anal Intercourse

Abstract Full Text
JAMA. 2022;327(13):1219. doi:10.1001/jama.2022.4556

FDA Expands Empagliflozin Heart Failure Indication

Abstract Full Text
JAMA. 2022;327(13):1219. doi:10.1001/jama.2022.3970

New Cancer Clinical Trial Guidance

Abstract Full Text
JAMA. 2022;327(13):1219. doi:10.1001/jama.2022.4561
Poetry and Medicine

DNA

Abstract Full Text
JAMA. 2022;327(13):1295. doi:10.1001/jama.2022.0822
JAMA Revisited

Psychiatric Sense and Nonsense

Abstract Full Text
JAMA. 2022;327(13):1296. doi:10.1001/jama.2021.16914
JAMA Patient Page

What Is Osteoarthritis?

Abstract Full Text
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JAMA. 2022;327(13):1300. doi:10.1001/jama.2022.1980

This JAMA Patient Page describes osteoarthritis and its risk factors, diagnosis, and treatment.

Comment & Response

Rivaroxaban vs Apixaban and Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation

Abstract Full Text
JAMA. 2022;327(13):1290. doi:10.1001/jama.2022.1425

Rivaroxaban vs Apixaban and Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation—Reply

Abstract Full Text
JAMA. 2022;327(13):1290. doi:10.1001/jama.2022.1428

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression

Abstract Full Text
JAMA. 2022;327(13):1290-1291. doi:10.1001/jama.2022.2030

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression

Abstract Full Text
JAMA. 2022;327(13):1291-1292. doi:10.1001/jama.2022.2027

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression—Reply

Abstract Full Text
JAMA. 2022;327(13):1292. doi:10.1001/jama.2022.2033

Mediterranean Diet or Mindfulness-Based Stress Reduction and Prevention of Small-for-Gestational-Age Birth Weights in Newborns

Abstract Full Text
JAMA. 2022;327(13):1292-1293. doi:10.1001/jama.2022.2164

Mediterranean Diet or Mindfulness-Based Stress Reduction and Prevention of Small-for-Gestational-Age Birth Weights in Newborns—Reply

Abstract Full Text
JAMA. 2022;327(13):1293-1294. doi:10.1001/jama.2022.2167

Notice of Retraction. Shah S. Five Miles From Tomorrow. JAMA. 2000;284:1897-1898

Abstract Full Text
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JAMA. 2022;327(13):1294. doi:10.1001/jama.2022.3950
Correction

Error in Figure

Abstract Full Text
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JAMA. 2022;327(13):1294. doi:10.1001/jama.2022.4059
JAMA Masthead

JAMA

Abstract Full Text
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JAMA. 2022;327(13):1209-1210. doi:10.1001/jama.2021.16911
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