October 3, 2017 Issue of JAMA

October 3, 2017, Vol 318, No. 13, Pages 1201-1294

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2017;318(13):1201-1203. doi:10.1001/jama.2016.13333

Podcast: Sepsis Resuscitation and Epidemiology, Bleeding From NOACs for AFib, Liquid Biopsies, and more

Original Investigation

Caring for the Critically Ill Patient

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial

Ben Andrews, MD; Matthew W. Semler, MD, MSc; Levy Muchemwa, MBChB; et al.

Abstract Full Text

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JAMA. 2017;318(13):1233-1240. doi:10.1001/jama.2017.10913

This randomized clinical trial compares the effects of an early resuscitation sepsis protocol (administration of intravenous fluids, vasopressors, and blood transfusion) vs usual care for prevention of in-hospital mortality among adults with sepsis and hypotension in Zambia.

Video: Effects of Early Goal-Directed Therapy vs Usual Care on In-Hospital Mortality Among Adults With Severe Sepsis in Zambia

Editorial
Trying to Improve Sepsis Care in Low-Resource Settings
Flavia R. Machado, MD, PhD; Derek C. Angus, MD, MPH

JAMA
- Video: Effects of Early Goal-Directed Therapy vs Usual Care on In-Hospital Mortality Among Adults With Severe Sepsis in Zambia

Caring for the Critically Ill Patient

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

Chanu Rhee, MD, MPH; Raymund Dantes, MD, MPH; Lauren Epstein, MD, MS; et al.

Abstract Full Text

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JAMA. 2017;318(13):1241-1249. doi:10.1001/jama.2017.13836

This cohort study compares estimates of sepsis incidence, outcomes, and trends based on clinical data from US hospital electronic health record systems vs claims-based ICD-9 data.

Editorial
Counting Sepsis, an Imprecise but Improving Science
Kristina E. Rudd, MD; Anthony Delaney, PhD, FCICM; Simon Finfer, MD, FCICM

JAMA

Association Between Use of Non鈥揤itamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding in Nonvalvular Atrial Fibrillation

Shang-Hung Chang, MD, PhD; I-Jun Chou, MD; Yung-Hsin Yeh, MD; et al.

Abstract Full Text

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JAMA. 2017;318(13):1250-1259. doi:10.1001/jama.2017.13883

This cohort study uses data from the Taiwan National Health Insurance database to assess the association between use of non鈥搗itamin K oral anticoagulants with vs without concurrent medications and risk of major bleeding in patients with nonvalvular atrial fibrillation.

Association Between Use of Antithrombotic Medication and Hematuria-Related Complications

Christopher J. D. Wallis, MD, PhD; Tristan Juvet, MD; Yuna Lee, MD, MEd; et al.

Abstract Full Text

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JAMA. 2017;318(13):1260-1271. doi:10.1001/jama.2017.13890

This population-based study characterize rates of hematuria-related complications among patients taking antithrombotic medications.

Research Letter

Incidence of Measles in the United States, 2001-2015

Nakia S. Clemmons, MPH; Gregory S. Wallace, MD, MPH; Manisha Patel, MD, MS; et al.

Abstract Full Text

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JAMA. 2017;318(13):1279-1281. doi:10.1001/jama.2017.9984

This study uses Centers for Disease Control and Prevention data to characterize trends in the incidence of measles among US residents from 2001 to 2015.

Viewpoint

Digital Phenotyping: Technology for a New Science of Behavior

Thomas R. Insel, MD

Abstract Full Text

JAMA. 2017;318(13):1215-1216. doi:10.1001/jama.2017.11295

In this Viewpoint, Thomas Insel discusses the possibility that sensor, keyboard, and voice and speech data from smartphones might be used as a digital phenotype to improve patient-specific measurement-based behavioral care.

Talking to Machines About Personal Mental Health Problems

Adam S. Miner, PsyD; Arnold Milstein, MD, MPH; Jefferey T. Hancock, PhD

Abstract Full Text

JAMA. 2017;318(13):1217-1218. doi:10.1001/jama.2017.14151

This Viewpoint describes trends in the use of conversational artificial intelligence in mental health care and discusses potential advantages and risks to patients and the public.

Measuring the Cost of Quality Measurement: A Missing Link in Quality Strategy

Mark A. Schuster, MD, PhD; Sarah E. Onorato, BA; David O. Meltzer, MD, PhD

Abstract Full Text

JAMA. 2017;318(13):1219-1220. doi:10.1001/jama.2017.11525

This Viewpoint discusses the importance of accounting for the cost of measurement in establishing the value of hospital quality measures.

Research Integrity, Academic Promotion, and Attribution of Authorship and Nonauthor Contributions

Spyros D. Mentzelopoulos, MD, PhD; Spyros G. Zakynthinos, MD, PhD

Abstract Full Text

JAMA. 2017;318(13):1221-1222. doi:10.1001/jama.2017.11790

This Viewpoint discusses the importance of research authorship for academic promotion and proposes revision of research integrity codes to define nonauthor contributions and distinguish nonauthor from author contributions to discourage awarding of authorship to nonauthor collaborators.

A Piece of My Mind

Full Disclosure: An OB/GYN鈥檚 Personal Story of Pregnancy Loss

Angela S. Kelley, MD

Abstract Full Text

JAMA. 2017;318(13):1223-1224. doi:10.1001/jama.2017.8737

Editorial

Trying to Improve Sepsis Care in Low-Resource Settings

Flavia R. Machado, MD, PhD; Derek C. Angus, MD, MPH

Abstract Full Text

has multimedia

JAMA. 2017;318(13):1225-1227. doi:10.1001/jama.2017.10547

Video: Effects of Early Goal-Directed Therapy vs Usual Care on In-Hospital Mortality Among Adults With Severe Sepsis in Zambia

Counting Sepsis, an Imprecise but Improving Science

Kristina E. Rudd, MD; Anthony Delaney, PhD, FCICM; Simon Finfer, MD, FCICM

Abstract Full Text

JAMA. 2017;318(13):1228-1229. doi:10.1001/jama.2017.13697

Announcing 糖心vlog Open鈥擜 New Journal From The 糖心vlog

Frederick P. Rivara, MD, MPH; Thomas J. Easley; Annette Flanagin, RN, MA; et al.

Abstract Full Text

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JAMA. 2017;318(13):1230-1232. doi:10.1001/jama.2017.11830

JAMA Insights

Genomics and Precision Health

Cancer DNA in the Circulation: The Liquid Biopsy

Hatim Husain, MD; Victor E. Velculescu, MD, PhD

Abstract Full Text

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JAMA. 2017;318(13):1272-1274. doi:10.1001/jama.2017.12131

This JAMA Insights article explains cell-free circulating tumor DNA and its utility in noninvasive cancer detection and characterization, prediction of treatment response, monitoring of disease relapse, and identification of mechanisms of resistance to targeted therapies.

Podcast: Replacing Tissue Biopsies With a Blood Test: The Technique of Liquid Biopsy

JAMA Clinical Evidence Synopsis

Long-Acting 尾-Agonists (LABA) Combined With Long-Acting Muscarinic Antagonists or LABA Combined With Inhaled Corticosteroids for Patients With Stable COPD

Nobuyuki Horita, MD, PhD; Akimichi Nagashima, MD, PhD; Takeshi Kaneko, MD, PhD

Abstract Full Text

JAMA. 2017;318(13):1274-1275. doi:10.1001/jama.2017.11903

This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of long-acting 尾-agonists (LABAs) combined with long-acting muscarinic antagonists vs LABAs combined with inhaled corticosteroids for patients with stable chronic obstructive pulmonary disease.

JAMA Diagnostic Test Interpretation

Urinalysis in the Evaluation of Proliferative Glomerulonephritis

Ziv Harel, MD, MSc; David L. Simel, MD, MHS; Ron Wald, MDCM, MPH

Abstract Full Text

JAMA. 2017;318(13):1276-1277. doi:10.1001/jama.2017.14482

A 62-year-old woman with hypertension and who had a urinary tract infection with hematuria 1 year ago presented with elevated serum creatinine. Her urinalysis was positive for hematuria, red blood cell casts, and proteinuria. How do you interpret the test results?

Medical News & Perspectives