May 9, 2017 Issue of JAMA

May 9, 2017, Vol 317, No. 18, Pages 1815-1920

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2017;317(18):1815-1817. doi:10.1001/jama.2016.13119

Podcast: Selumetinib for lung cancer, postmarket drug safety, screening for thyroid cancer, and more

Original Investigation

Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non鈥揝mall Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial

Pasi A. Jänne, MD; Michel M. van den Heuvel, MD; Fabrice Barlesi, MD; et al.

Abstract Full Text

free access

JAMA. 2017;317(18):1844-1853. doi:10.1001/jama.2017.3438

This randomized clinical trial compares the effects of survival of the MEK inhibitor selumetinib plus docetaxel vs docetaxel alone as second-line therapy for advanced KRAS-mutant non鈥搒mall cell lung cancer.

Editorial
Treatment of KRAS-Mutant Non鈥揝mall Cell Lung Cancer: The End of the Beginning for Targeted Therapies
Jacob Kaufman, MD, PhD; Thomas E. Stinchcombe, MD

JAMA

Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010

Nicholas S. Downing, MD; Nilay D. Shah, PhD; Jenerius A. Aminawung, MD, MPH; et al.

Abstract Full Text

free access

JAMA. 2017;317(18):1854-1863. doi:10.1001/jama.2017.5150

This study describes withdrawals, boxed warnings, and safety communications affecting pharmaceuticals and biologics approved by the US Food and Drug Administration between 2001 and 2010, and associations between characteristics known at the time of approval and those events.

Assessment of Global Kidney Health Care Status

Aminu K. Bello, PhD; Adeera Levin, FRCPC; Marcello Tonelli, MD; et al.

Abstract Full Text

free access

JAMA. 2017;317(18):1864-1881. doi:10.1001/jama.2017.4046

This study surveyed international nephrology society leaders, policy makers, and patient representatives to assess regional resources and ability to care for patients with kidney disease.

Editorial
Worldwide Preparedness for Kidney Health Care
Sreedhar Mandayam, MD, MPH; Wolfgang C. Winkelmayer, MD, MPH, ScD

JAMA

Research Letter

Association Between Long-term Quinine Exposure and All-Cause Mortality

Laurence Fardet, MD, PhD; Irwin Nazareth, MD, PhD; Irene Petersen, PhD

Abstract Full Text

free access

JAMA. 2017;317(18):1907-1909. doi:10.1001/jama.2017.2332

This cohort study uses UK primary care database data to explore the association between long-term quinine exposure and all-cause mortality.

US Preventive Services Task Force

Recommendation Statement

Screening for Thyroid Cancer: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

free access has audio

JAMA. 2017;317(18):1882-1887. doi:10.1001/jama.2017.4011

This Recommendation Statement from the US Preventive Services Task Force recommends against screening for thyroid cancer in asymptomatic adults (D recommendation).

Podcast: Screening for Thyroid Cancer

Editorial
How to Look for Thyroid Cancer
Anne R. Cappola, MD, ScM

JAMA
Cancer Screening, Overdiagnosis, and Regulatory Capture
H. Gilbert Welch, MD, MPH

JAMA Intern Med
The USPSTF Recommendation on Thyroid Cancer Screening: Don鈥檛鈥淐heck Your Neck鈥�
Louise Davies, MD, MS; Luc G. T. Morris, MD, MSc

JAMA Otolaryngol Head Neck Surg

Evidence Report

Screening for Thyroid Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Jennifer S. Lin, MD, MCR; Erin J. Aiello Bowles, MPH; Selvi B. Williams, MD, MPH; et al.

Abstract Full Text

free access

JAMA. 2017;317(18):1888-1903. doi:10.1001/jama.2017.0562

This Evidence Report to support the 2017 update of the US Preventive Services Task Force Recommendation Statement on screening for thyroid cancer summarizes evidence about the benefits and harms associated with thyroid cancer screening and treatment of early thyroid cancer in asymptomatic adults.

Editorial
How to Look for Thyroid Cancer
Anne R. Cappola, MD, ScM

JAMA
Cancer Screening, Overdiagnosis, and Regulatory Capture
H. Gilbert Welch, MD, MPH

JAMA Intern Med
The USPSTF Recommendation on Thyroid Cancer Screening: Don鈥檛鈥淐heck Your Neck鈥�
Louise Davies, MD, MS; Luc G. T. Morris, MD, MSc

JAMA Otolaryngol Head Neck Surg

Viewpoint

Toward Responsible Human Genome Editing

Richard O. Hynes; Barry S. Coller, MD; Matthew Porteus, MD, PhD

Abstract Full Text

JAMA. 2017;317(18):1829-1830. doi:10.1001/jama.2017.4548

This Viewpoint discusses recommendations the US National Academies of Sciences and Medicine made in 2017 for the application and oversight of human genome editing in basic research, clinical disease, and germline cells.

Genomics, Health Disparities, and Missed Opportunities for the Nation鈥檚 Research Agenda

Kathleen McGlone West, MS, MPH; Erika Blacksher, PhD; Wylie Burke, MD, PhD

Abstract Full Text

JAMA. 2017;317(18):1831-1832. doi:10.1001/jama.2017.3096

This Viewpoint discusses the complexities of the health disparities in the United States and argues for better integration of genomic basis for understanding health disparities with social models of disease and disparities.

A Piece of My Mind

Medical Education and the Minority Tax

Kali D. Cyrus, MD, MPH

Abstract Full Text

JAMA. 2017;317(18):1833-1834. doi:10.1001/jama.2017.0196

Editorial

Treatment of KRAS-Mutant Non鈥揝mall Cell Lung Cancer: The End of the Beginning for Targeted Therapies

Jacob Kaufman, MD, PhD; Thomas E. Stinchcombe, MD

Abstract Full Text

JAMA. 2017;317(18):1835-1837. doi:10.1001/jama.2017.3436

Worldwide Preparedness for Kidney Health Care

Sreedhar Mandayam, MD, MPH; Wolfgang C. Winkelmayer, MD, MPH, ScD

Abstract Full Text

JAMA. 2017;317(18):1838-1839. doi:10.1001/jama.2017.2825

How to Look for Thyroid Cancer

Anne R. Cappola, MD, ScM

Abstract Full Text

JAMA. 2017;317(18):1840-1841. doi:10.1001/jama.2017.4068

Genomics and Precision Health

Introducing 鈥淕enomics and Precision Health鈥�

W. Gregory Feero, MD, PhD

Abstract Full Text

free access has multimedia has audio

JAMA. 2017;317(18):1842-1843. doi:10.1001/jama.2016.20625

Podcast: Genomics and Precision Health

JAMA Insights

Genomics and Precision Health

Finding the Rare Pathogenic Variants in a Human Genome

James P. Evans, MD, PhD; Bradford C. Powell, MD, PhD; Jonathan S. Berg, MD, PhD

Abstract Full Text

has audio

JAMA. 2017;317(18):1904-1905. doi:10.1001/jama.2017.0432

This Genomics and Precision Health essay discusses the risks and potential benefits of performing genome sequencing in healthy people.

Podcast: Genomic Sequencing for the Healthy Individual?:聽Think Smaller

Editorial
Introducing 鈥淕enomics and Precision Health鈥�
W. Gregory Feero, MD, PhD

JAMA
- Podcast: Genomics and Precision Health

Medical News & Perspectives

Farewell to a Cancer That Never Was

Jeff Lyon

Abstract Full Text

JAMA. 2017;317(18):1824-1825. doi:10.1001/jama.2017.3969

This Medical News story follows up on the recent downgrading of a form of thyroid cancer to a noncancerous neoplasm.

News From the Centers for Disease Control and Prevention

How Much Do You Drink?

Abstract Full Text

JAMA. 2017;317(18):1827. doi:10.1001/jama.2017.4666

Medicaid鈥檚 Impact on Overdose Rates

Abstract Full Text

JAMA. 2017;317(18):1827. doi:10.1001/jama.2017.5101

Capitol Health Call

Investigation Into Opioid Crisis Targets Drug Companies

Jeff Lyon

Abstract Full Text

JAMA. 2017;317(18):1826. doi:10.1001/jama.2017.5130

Hearing Focuses on Proposed Cuts in Cancer Research

Jeff Lyon

Abstract Full Text

JAMA. 2017;317(18):1826. doi:10.1001/jama.2017.5383

Maker of Duodenoscopes Under Scrutiny Again

Jeff Lyon

Abstract Full Text

JAMA. 2017;317(18):1826. doi:10.1001/jama.2017.5385

The Arts and Medicine

The Center Cannot Hold: Medicine, Music, and the Mind

Stefan N. Willich, MD, MPH, MBA

Abstract Full Text

has multimedia

JAMA. 2017;317(18):1822-1823. doi:10.1001/jama.2017.4690

This Arts and Medicine essay reviews the 2-act chamber opera The Center Cannot Hold, which tells the story of Elyn Saks, who developed schizophrenia in childhood but went on to become a law professor and mental health advocate.

Video: The Center Cannot Hold: Part One - The Illness: A Chamber Opera in Two Acts
Video: The Center Cannot Hold: Trio