There are few diseases like syphilis, for which our therapeutical actions are so well defined, for which we possess specific remedies, upon whose never-failing effect we count with nearly absolute certainty; yet nowhere is the Eatin phrase equally true: duo si faciunt idem, non semper est idem. The where, when, and how to use those two chief agents, mercury and iodine, seems to be to many a terra incognita, and the prescribing of the mixed treatment forms the beginning and the end of their fight against that dread disease, in whatever phase it may be, whether it has attacked the skin only or other more important organs. The result of this laisser aller is often a very sad one, and many a perforated septum or palate, or even the loss of a considerable part of the nose is due to the fact that local treatment has not been given a