The 2019 CDC STD Surveillance Report found that the annual cases of STIs in the US continued to increase in 2019, totaling more than an estimated 2.5 million cases of chlamydia, gonorrhea, and syphilis; congenital syphilis increased by 279% between 2015 and 2019.¹ STIs have increased across multiple groups, but disproportionately affect racial and ethnic minority groups, gay and bisexual men, and youth.² These guidelines address STI topics including general prevention, vaccination, appropriate sexual history taking, screening, treatment, and partner therapy.³

This Clinical Guideline Synopsis focuses on gonorrhea, chlamydia, Mycoplasma genitalium, and syphilis prevention, diagnosis, and management. The updated CDC guidelines use the terms men/women or male/female and also include STI screening recommendations for transgender women, transgender men, and gender-diverse persons as well as for other patient populations including pregnant people, those living in correctional facilities, and those who have experienced sexual abuse and assault.