In Reply We agree with Dr Asadi-Pooya’s point that the currently published evidence base for the psychotherapeutic treatment of PNEA remains limited, consisting primarily of observational studies and 2 small randomized clinical trials. However, as briefly mentioned in our Viewpoint,¹ a large, adequately powered multisite randomized trial (the CODES trial; ), comparing cognitive behavioral therapy plus standard medical care with standard medical care alone, has recently completed enrollment and data collection, with results forthcoming.² This study includes assessments of monthly PNEA frequency as the primary outcome, with numerous secondary outcomes, including quality of life, psychological distress, psychosocial functioning, and health service use. Follow-up was conducted at intervals of 6 and 12 months.