Explore the latest in pharmocogenetics, including advances in personalized medicine from genetic markers of drug efficacy and adverse effects.
This consensus statement examines genetic discrimination worldwide and identifies issues to be addressed by policymakers.
This mendelian randomization study uses mendelian randomization to investigate potential causal relationships between perturbing maternal genetic variants influencing antihypertensive drug targets and perinatal outcomes among offspring.
This systematic review and meta-analysis quantifies differences in plasma concentrations for antiseizure drugs associated with variants of genes encoding drug metabolizing enzymes, particularly CYP2C9 and CYP2C19.
This cohort study examines the association of offsprings鈥� body mass index at age 17 years with the body mass index of their parents at the same age.
This comparative effectiveness analysis examines the outcomes of pediatric patients with acute myeloid leukemia (AML) by race and cytarabine pharmacogenomics.
This prognostic study examines the utility of tumor-stroma proportion as a predictive biomarker for chemoresistance among patients with ovarian cancer.
This cross-sectional study investigates rates of dispensing of medications with a high level of evidence for pharmacogenetic-guided testing from 2011 to 2019 among youths with Medicaid.
This Viewpoint addresses the challenges that the Centers for Medicare and Medicaid Services faces to collect real-world data on the effectiveness and safety of lecanemab from external registries to achieve its coverage with evidence development objectives.
This genetic association study including genome-wide association study summary statistics of US and European adults uses mendelian randomization analysis to examine the association of genetic proxies of thiazide diuretics with the risk of kidney stones.
This study examines the frequency of drug patent invalidations based on inequitable conduct.
This randomized clinical trial evaluates the clinical effectiveness of multigenetic pharmacogenomics鈥揼uided treatment in schizophrenia among Han men in China.
This Viewpoint discusses whether routine vaccination is safe for children with MT-RNR1 gene variants that predispose to aminoglycoside-induced hearing loss.
This prespecified subgroup analysis of the randomized clinical CHANCE-2 trial investigates whether the efficacy and safety of ticagrelor-aspirin vs clopidogrel-aspirin are consistent with the expected degree of CYP2C19 loss-of-function after transient ischemic attack or minor stroke.
This randomized clinical trial examines whether tricyclic antidepressant (TCA) dosing based on pharmacogenetics according to the Dutch Pharmacogenetics Working Group guidelines results in faster attainment of therapeutic TCA plasma concentrations compared with usual treatment.
This Viewpoint discusses the findings of the Clarity AD trial, which studied lecanemab for patients with early-stage Alzheimer disease.
This case-control study pools and analyzes individual-level data from 8 Ovarian Cancer Association Consortium case-control studies to evaluate whether a polygenic score modifies the association of frequent aspirin use with ovarian cancer.
This secondary analysis of a randomized clinical trial assesses whether GC gene missense variants encoding common vitamin D鈥揵inding protein isoforms modify the effects of vitamin D3 and/or calcium supplementation on colorectal adenoma recurrence risk.
This cohort study examines the use of targeted therapies, including epithelial growth factor receptor inhibitors and vascular endothelial growth factor inhibitors, in the treatment of patients with metastatic colorectal cancer.
This genetic association study replicated previously identified genetic factors and assessed novel genetic factors associated with hepatic toxic effects during treatment in pediatric patients with acute lymphoblastic leukemia (ALL).
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