Explore the latest in clinical pharmacy and pharmacology, including topics in drug safety, development, pharmacogenetics, and pharmacoeconomics.
This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patients with atherosclerotic cardiovascular disease and elevated lipoprotein(a) concentration.
This secondary analysis of 4 randomized clinical trials investigates the association of MDMA with activation of the oxytocin and vasopressin systems, the incidence and severity of MDMA-induced hyponatremia, and the role of fluid restriction in lowering the risk of hyponatremia.
This randomized clinical trial evaluates the efficacy and safety of first-line toripalimab vs placebo plus etoposide and platinum-based chemotherapy for treating patients with extensive-stage small cell lung cancer.
This case-control study investigates the risk of rhabdomyolysis among patients receiving sodium-glucose cotransporter-2 (SGLT2) inhibitors.
This Viewpoint describes what dermatologists should know about doxycycline postexposure prophylaxis (doxyPEP) for bacterial sexually transmitted infection (STI) prevention, specifically syphilis, chlamydia, and gonorrhea.
This case report describes a patient with Sweet syndrome whose condition improved with spesolimab after failure of high-dose corticosteroids.
This case-case-time-control study evaluates the association between gabapentinoids and the risk of hip fractures among older adults in Australia.
This randomized trial assesses the effect of intratracheal budesonide mixed with surfactant on survival free of bronchopulmonary dysplasia in extremely preterm infants.
This randomized clinical trial examines the use of sequential therapy with zoledronate to prevent loss of bone mineral density after denosumab discontinuation in the first year.
This Viewpoint discusses the need to better understand potential risks associated with psychedelic and 3,4-methylenedioxymethamphetamine (MDMA) use to ensure safe and ethical practice and identifies 4 key research goals.
This Viewpoint highlights financial toxicity specific to Asian American cancer survivors and presents steps forward within the framework of the social ecological model of health, considering individual, interpersonal, community, and policy-level dimensions.
This JAMA Insights discusses the important role that interpreters play in facilitating communication between patients with limited English-language proficiency and their health care team and provides steps that can be taken to improve communication with remote interpreters for patients.
This phase 1b/2 nonrandomized clinical trial evaluates whether equecabtagene autoleucel can benefit patients with relapsed or refractory multiple myeloma and determines the overall response rate after infusion.
This cross-sectional study compares the use of management tools and plan-level total costs for oral ondansetron between Part D independent prescription drug plans and Medicare Advantage prescription drug plans.
This systematic review and meta-analysis evaluates adverse effects in offspring of mothers taking atomoxetine and methylphenidate during pregnancy.
This randomized clinical trial compares reactogenicity, safety, and short-term health-related quality-of-life outcomes after simultaneous vs sequential receipt of messenger RNA (mRNA) COVID-19 and influenza vaccines.
This stepped-wedge cluster randomized clinical trial evaluates a multipronged physician-directed intervention with clinical decision support of anticoagulation initiation for eligible adult emergency department patients.
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