Explore the latest in valvular heart disease, including advances in diagnosis and management of mitral and aortic valve disease, TAVR, and more.
This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patients with atherosclerotic cardiovascular disease and elevated lipoprotein(a) concentration.
This narrative review explores treatment with surgical aortic valve replacement vs transcatheter aortic valve implantation in older adults with severe symptomatic calcific aortic stenosis, including the type and timing of valve replacement.
This cross-sectional study investigates the prevalence of heart failure with preserved ejection fraction (HFpEF) in severe isolated secondary tricuspid regurgitation and the performance of noninvasive measures in its detection.
This genomewide association study examined specific genetic variants, pathways, and tissues associated with aortic stenosis independent of coronary artery disease in a meta-analysis of participants from 3 European cohorts.
This cohort study examines the association of transcatheter aortic valve implantation (TAVI) with gastrointestinal vascular lesions among patients with aortic stenosis and gastrointestinal bleeding secondary to vascular lesions.
This cohort study assesses characteristics and outcomes of younger patients undergoing transcatheter aortic valve replacement.
This cohort study evaluates the psychometric properties of the Kansas City Cardiomyopathy Questionnaire in patients with tricuspid regurgitation using pooled data from 11 manufacturer-sponsored trials of transcatheter tricuspid valve interventions.
This randomized clinical trial evaluates regional differences in the association between stroke outcomes and cerebral embolic protection.
This randomized clinical trial examines whether early valve intervention will reduce the incidence of all-cause death or unplanned aortic stenosis鈥搑elated hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis.
After he learned that his congenital bicuspid aortic valve needed replacement, a urologic oncologist describes, in this narrative medicine essay, the pain and helplessness he felt while recovering from surgery.
This narrative review analyzes associations among heart failure, aortic stenosis, and aortic valve replacement.
This cohort study examines changes in risk-adjusted transcatheter aortic valve replacement (TAVR) outcomes from 2019 to 2022 using data from the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapies (TVT) Registry.
This randomized clinical trial compares the safety and efficacy of an upper- vs a lower-extremity approach for clinically relevant secondary access site鈥搑elated bleeding in patients undergoing transfemoral transcatheter aortic valve implantation.
This prespecified secondary analysis of a randomized clinical trial evaluates clinical and hemodynamic outcomes by valve type in transcatheter aortic valve replacement among women with small aortic annuli.
This retrospective cohort study investigates the prevalence, clinical characteristics, and outcomes of mitral valve surgery in atrial functional mitral regurgitation among adults in Japan.
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