Explore the latest in cancer genetics, including advances in precision therapy from whole exome sequencing and tumor molecular profiling.
This cohort study examines the association of age with late distant recurrence in patients aged 45 years or younger with estrogen receptor (ER)鈥損ositive, ERBB2-negative breast cancer.
This case series examines treatment with anti鈥損rogrammed cell death 1 (PD1) immunotherapy for patients with basal cell nevus syndrome.
This cross-sectional study reports on environmental heat and cold exposure鈥搑elated burden and analyzes its temporal trends among children and adolescents from 1990 to 2019 using data from the Global Burden of Disease Study 2019.
This cohort study assesses clinical evidence from patients with advanced lung adenocarcinoma and compares the detection of National Comprehensive Cancer Network鈥搑ecommended actionable structural variants (aSVs) via concurrent DNA next-generation sequencing (NGS) and RNA-NGS vs DNA-NGS alone.
This cross-sectional study evaluates longitudinal cancer mortality trends among Asian American and Pacific Islander populations in the US by demographic characteristics.
In this narrative medicine essay, a pediatrician thwarted a likely fatal cancer after undergoing genetic testing after noticing a pattern in her family that turned out to be caused by a genetic variation.
This secondary analysis of a randomized clinical trial reports primary care clinician outcomes of decision support tools for referral of patients with potential BRCA1/2 mutations for genetic counseling.
This cohort study examines the institution-level and patient-level factors associated with mismatch repair and microsatellite testing for individuals with colorectal cancer.
This consensus statement examines genetic discrimination worldwide and identifies issues to be addressed by policymakers.
This diagnostic/prognostic study evaluates prediction models for high nodal burden in luminal ERBB2-negative breast cancer.
This cross-sectional study examines whether patients meeting the family history criteria for genetic testing for breast cancer can be identified through electronic health records.
This diagnostic study assesses the performance metrics of tumor tissue鈥搈odified human papillomavirus (HPV) DNA testing for diagnosing oropharyngeal squamous cell carcinoma in patients with a lateral neck mass.
This case-control study examines the interactions between West African genetic ancestry and neighborhood deprivation in association with modifying prostate cancer risk and mortality among Black and White US men.
This cohort study examines the risk of radiation-associated sarcoma in patients with breast cancer harboring germline TP53 variants.
This economic evaluation estimates the incremental lifetime health outcomes, costs, and cost-effectiveness associated with population-based BRCA testing compared with family history鈥揵ased testing in a simulated cohort of women in Canada.
This randomized clinical trial examines whether chatbot and standard-of-care delivery models are equivalent in completion of pretest cancer genetic services and genetic testing among primary care patients.
This cross-sectional study examines clinicogenomic features of Lynch syndrome and characterizes responses to immune checkpoint blockade therapy.
This study reanalyzes epidermal growth factor receptor 2 (ERBB2) data from a previous study to characterize patient subgroups with ERBB2-low tumors.
This cross-sectional study evaluates the prevalence and clinicopathological associations of germline pathogenic or likely pathogenic variants in 2 groups of breast cancer susceptibility genes among a racially and ethnically diverse cohort of women with newly diagnosed breast cancer.
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