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Lack of physical activity can lead to a number of health problems, but scientists have discovered a new reason why sitting is so bad for us. Sitting for too long can lead to cancer and increased risk of diabetes. It can also double a person's risk of developing cardiovascular disease. Staying seated for too long can lead to a buildup of proteins called troponins, which are released by heart muscle cells when they're damaged. People who sit more than 10 hours a day had above-normal levels of troponins. If those elevated levels continue, it could explain why people who sit for long periods of time are more likely to die from cardiovascular problems than people who are more active.